Results 11 to 20 of about 2,585 (117)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

New glycoside hydrolase families of β‐1,2‐glucanases

Protein Science, Volume 34, Issue 6, June 2025.
Abstract β‐1,2‐Glucans are natural glucose polymers produced by bacteria and play important physiological roles, including as symbiotic or pathogenic factors and in osmoregulation. Glycoside hydrolase (GH) families related to β‐1,2‐glucan metabolism (GH144, GH162, and GH189) have recently been created by identification of two β‐1,2‐glucanases and a β‐1,
Masahiro Nakajima, Nobukiyo Tanaka, Sei Motouchi, Kaito Kobayashi, Hisaka Shimizu, Koichi Abe, Naoya Hosoyamada, Naoya Abara, Naoko Morimoto, Narumi Hiramoto, Ryosuke Nakata, Akira Takashima, Marie Hosoki, Soichiro Suzuki, Kako Shikano, Takahiro Fujimaru, Shiho Imagawa, Yukiya Kawadai, Ziyu Wang, Yoshinao Kitano, Takanori Nihira, Hiroyuki Nakai, Hayao Taguchi   +22 more
wiley   +1 more source

Elucidating the Mechanism of Temporal Adaptation to Hydrogen Peroxide‐Induced Oxidative Stress in Corynebacterium glutamicum

Microbial Biotechnology, Volume 18, Issue 6, June 2025.
In this study, RNA‐seq was employed to investigate the temporal transcriptional response of C. glutamicum ATCC 13032 to external H2O2 at 720 mM (2.45% w/w). The results reveal significant changes in gene expression across multiple pathways, including peroxide scavenging, central metabolism, sulphur and iron metabolism, amino acid biosynthesis, and DNA ...
Chang Yu, Wenjing Hu, Xiaoyu Li, Yu Lei, Dandan Gao, Meng Wang, Ping Zheng, Yan Zhu, Jibin Sun   +8 more
wiley   +1 more source

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16

The FEBS Journal, Volume 292, Issue 11, Page 2771-2783, June 2025.
Purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans, but remains poorly understood in metazoan. To investigate the impact of dietary components on purine metabolism and animal growth, we screened the effects of an Escherichia coli single‐gene deletion library on the growth of the nematode ...
Min Feng, Baizhen Gao, L. Rene Garcia, Qing Sun   +3 more
wiley   +1 more source

From data to discovery: leveraging big data in plant natural products biosynthesis research

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie, Tuan‐Anh Minh Nguyen, Truc Kim, Trinh‐Don Nguyen, Thu‐Thuy T. Dang   +4 more
wiley   +1 more source

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Mitonuclear Communication in Stem Cell Function

Cell Proliferation, Volume 58, Issue 5, May 2025.
In this review, we highlight the critical functions of mitonuclear communication and its impact on mitochondrial proteostasis. Additionally, we examine how mitonuclear signalling influences stem cell function, offering new insights into cellular homeostasis, stem cell therapies, and the potential for lifespan extension.
Baozhou Peng, Yaning Wang, Hongbo Zhang
wiley   +1 more source

The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration

Journal of Neurochemistry, Volume 169, Issue 5, May 2025.
Kynurenine pathway enzyme knockouts impair mitochondrial respiration. The deletion of kynurenine aminotransferase genes leads to significant impairment of mitochondrial respiration and ATP production, highlighting the critical role these enzymes play in cellular energy metabolism.
László Juhász, Krisztina Spisák, Boglárka Zsuzsa Szolnoki, Anna Nászai, Ágnes Szabó, Attila Rutai, Szabolcs Péter Tallósy, Andrea Szabó, József Toldi, Masaru Tanaka, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, Etsuro Ono, Mihály Boros, József Kaszaki, László Vécsei   +17 more
wiley   +1 more source

Proteome Reprogramming and Acquired Stress Tolerance in Potato Cells Exposed to Acute or Stepwise Water Deficit

Plant, Cell &Environment, Volume 48, Issue 5, Page 2875-2894, May 2025.
ABSTRACT Water deficit negatively impacts crop productivity and quality. Plants face these challenges by adjusting biological processes and molecular functions according to the intensity and duration of the stress. The cultivated potato (Solanum tuberosum) is considered sensitive to water deficit, thus breeding efforts are needed to enhance its ...
Elisa Cappetta, Carmine Del Regno, Sara Ceccacci, Maria Chiara Monti, Lucio Spinelli, Marisa Conte, Chiara D'Anna, Mariaevelina Alfieri, Mariapia Vietri, Antonello Costa, Antonietta Leone, Alfredo Ambrosone   +11 more
wiley   +1 more source

PROPERTIES OF CRYSTALLINE l-ASPARTATE 4-CARBOXY-LYASE FROM ACHROMOBACTER SP. [PDF]

, 1963
EM WILSON, H.L. Kornberg
openalex   +1 more source