Results 21 to 30 of about 2,535 (131)
Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16
The FEBS Journal, Volume 292, Issue 11, Page 2771-2783, June 2025.Purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans, but remains poorly understood in metazoan. To investigate the impact of dietary components on purine metabolism and animal growth, we screened the effects of an Escherichia coli single‐gene deletion library on the growth of the nematode ...
Min Feng +3 more
wiley +1 more source
From data to discovery: leveraging big data in plant natural products biosynthesis research
The Plant Journal, Volume 122, Issue 6, June 2025.SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie +4 more
wiley +1 more source
Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
Mitonuclear Communication in Stem Cell Function
Cell Proliferation, Volume 58, Issue 5, May 2025.In this review, we highlight the critical functions of mitonuclear communication and its impact on mitochondrial proteostasis. Additionally, we examine how mitonuclear signalling influences stem cell function, offering new insights into cellular homeostasis, stem cell therapies, and the potential for lifespan extension.
Baozhou Peng, Yaning Wang, Hongbo Zhang
wiley +1 more source
The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration
Journal of Neurochemistry, Volume 169, Issue 5, May 2025.Kynurenine pathway enzyme knockouts impair mitochondrial respiration. The deletion of kynurenine aminotransferase genes leads to significant impairment of mitochondrial respiration and ATP production, highlighting the critical role these enzymes play in cellular energy metabolism.
László Juhász +17 more
wiley +1 more source
Plant, Cell &Environment, Volume 48, Issue 5, Page 2875-2894, May 2025.ABSTRACT Water deficit negatively impacts crop productivity and quality. Plants face these challenges by adjusting biological processes and molecular functions according to the intensity and duration of the stress. The cultivated potato (Solanum tuberosum) is considered sensitive to water deficit, thus breeding efforts are needed to enhance its ...
Elisa Cappetta +11 more
wiley +1 more source
EFSA Journal, Volume 23, Issue 5, May 2025.Abstract The food enzyme acetolactate decarboxylase (α‐acetolactate decarboxylase; EC 4.1.1.5) is produced with the genetically modified Bacillus subtilis strain DP‐Ezz65 by Genencor International B.V. The genetic modifications do not give rise to safety concerns. The production strain meets the requirements for the qualified presumption of safety (QPS)
EFSA Panel on Food Enzymes (FEZ) +18 more
wiley +1 more source
Expanding the Substrate Scope of C−N Lyases by Homologue Discovery
ChemBioChem, Volume 26, Issue 7, April 1, 2025.A homology‐based strategy is employed to identify and biochemically characterize 13 enzymes homologous to ethylenediamine‐N,N‐disuccinic acid (EDDS) lyase. Several homologues exhibit a broadened substrate scope, accepting L‐amino acids for the enantioselective hydroamination of fumarate to produce the corresponding aminopolycarboxylic acids.
Laura Bothof +3 more
wiley +1 more source
Advanced Science, Volume 12, Issue 12, March 27, 2025.Pseudomonas fluorescens 2P24 utilizes a LasI/LasR‐type quorum sensing (QS) system, MupI/MupR, to regulate carbon and nitrogen metabolism for optimal production of secondary metabolites as public goods, including 2,4‐diacetylphloroglucinol, mupirocin, and siderophores.
Jie Li +11 more
wiley +1 more source
Plant Biotechnology Journal, Volume 23, Issue 2, Page 592-614, February 2025.Summary Pigments, as coloured secondary metabolites, endow the world with a rich palette of colours. They primarily originate from plants and microorganisms and play crucial roles in their survival and adaptation processes. In this article, we categorize pigments based on their chemical structure into flavonoids, carotenoids, pyrroles, quinones ...
Qian Tang +4 more
wiley +1 more source