Results 31 to 40 of about 79,493 (196)

Functional and structural characterization of Stenotrophomonas maltophilia EntB, an unusual form of isochorismatase for siderophore synthesis. [PDF]

Acta Crystallogr F Struct Biol Commun
The crystal structure of S. maltophilia EntB revealed an unusual form of isochorismate lyase that is involved in siderophore biosynthesis.Clinical and environmental isolates of Stenotrophomonas maltophilia produce an enterobactin‐like siderophore that promotes bacterial growth under low‐iron conditions.
Nas MY, Gabell J, Inniss N, Minasov G, Shuvalova L, Satchell KJF, Cianciotto NP.   +6 more
europepmc   +2 more sources

Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes : implications for classification of enzyme function [PDF]

, 2010
The authors thank the National Institutes of Health (NIH R01 GM60595 to PCB) and the Scottish Universities Life Sciences Alliance (SULSA to JBOM) for funding.Functionally analogous enzymes are those that catalyze similar reactions on similar substrates ...
Daniel E. Almonacid, Emmanuel R. Yera, John B. O. Mitchell, Patricia C. Babbitt, Christine A. Orengo, RA George, JA Gerlt, PC Babbitt, JA Gerlt, ME Glasner, GJ Bartlett, MY Galperin, H Hegyi, ACR Martin, PF Gherardini, AE Todd, AE Todd, Z Zhang, S Tsoka, SA Teichmann, TD Otto, NH Horowitz, RA Jensen, GA Petsko, RA Chiang, CS Wright, BW Matthews, SC Morris, N Nagano, CT Porter, C Andreini, C Andreini, GL Holliday, GL Holliday, SC-H Pegg, SC-H Pegg, N Nagano, AG Murzin, G Ausiello, H Berman, NM O'Boyle, P Jaccard, P Willett, TF Smith, CA Orengo, AG McDonald, ACR Martin, SB Needleman, M Kotera, Y Yamanishi, GL Holliday, L Maveyraud, J Pitarch, R Castillo, JC Hermann, Z Wang, AP Leech, DG Gourley, AW Roszak, LM Blomberg, A Matte, MM Benning, PC Babbitt, DL Scott, BW Segelke, YS Ho, YS Ho, ME Lowe, Y Bourne, RJ Kazlauskas, H van Tilbeurgh, GJ Bartlett, T Nakai, A Zajc, E Ortlund, AB Hickman, TJ Wyckoff, CR Sweet, W Plaga, V Leppänen, F Himo, M Mathieu, Y Modis, RF Doolittle, V Sangar, BE Shakhnovich, PW Lord, J Gasteiger, O Sacher, DARS Latino, DARS Latino, DARS Latino, Y Loewenstein, T Dandekar, R Overbeek, AJ Enright, EM Marcotte, M Pellegrini, JC Hermann, JC Hermann, ME Glasner, L Jiang, M Bashton, K Tipton, KA Olszewski, R Preißner, J Park, PR Mittl, S Lorenzen, A Fersht, M Errami, EO Cannon, M Rizzi, J Symersky, Y Devedjiev, AR Battersby, N Frankenberg, MA Mathews, HL Schubert, B Stec, L Ma, JE Murphy, EB Fauman, RH Hoff, F Wang   +124 more
core   +3 more sources

Exploring the biosynthetic pathways of glutamate and benzoate in Syntrophus aciditrophicus [PDF]

, 2011
In syntrophischer Lebensweise oxidiert Syntrophus aciditrophicus Benzoat zu Acetat und CO2, während axenische Kulturen Crotonat zu Acetat und Cyclohexancarboxylat mit etwas Benzoat fermentieren.
Kim, Marie
core   +1 more source

Kinetische und strukturelle Untersuchungen der Thiamindiphosphat-abhängigen Enzyme α-Ketosäuredecarboxylase aus Mycobacterium tuberculosis und Oxalyl-CoA-Decarboxylase aus Escherichia coli [PDF]

, 2008
In der vorliegenden Arbeit wurden zwei Thiamindiphosphat (ThDP)-abhängige Carboxylyasen, eine α-Ketosäuredecarboxylase aus Mycobacterium tuberculosis (MtKDC) und eine Oxalyl-CoA-Decarboxylase aus Escherichia coli, kinetisch und strukturell ...
Werther, Tobias
core   +1 more source

COMPARATIVE APPROACHES FOR PLANT GENOMES: UNRAVELING "INTRA" AND "INTER" SPECIES RELATIONSHIPS FROM PRELIMINARY GENE ANNOTATIONS [PDF]

, 2016
Comparative genomics studies the differences and similarities between different species, to transfer biological information from model organisms to newly sequenced genomes, and to understand the evolutionary forces that drive changes in genomic features ...
Ambrosino, Luca
core  

Understanding the enzymatic and cometabolic biotransformation of organic micropollutants under aerobic heterotrophic conditions [PDF]

, 2022
O obxectivo principal desta tese é profundar no coñecemento da biotransformación dos microcontaminantes orgánicos (MCOs) en condicións aerobias heterótrofas, analizando se se produce de forma cometabólica e en función de que mecanismos e actividades ...
Kennes Veiga, David Manuel
core  

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Establishment, validation and application of immunological and LC-MS/MS-based detection methods to study the role of human aromatic L-amino acid decarboxylase as an enzyme potentially involved in thyronamine biosynthesis [PDF]

, 2012
Thyronamine (TAM) sind eine neue Molekülklasse, die endokrinologische und metabolische Prozesse miteinander vereinen. Der biologisch aktive Metabolit 3-Iod-L-Thyronamin (3-T1AM) wird durch eine kombinierte Deiodierung und Decarboxylierung von ...
Höfig, Carolin
core   +1 more source

Tailored impact of dietary fibers on gut microbiota: a multi-omics comparison on the lean and obese microbial communities [PDF]

Background Previous studies have shown that microbial communities differ in obese and lean individuals, and dietary fiber can help reduce obesity-related conditions through diet-gut microbiota interactions. However, the mechanisms by which dietary fibers
Dell'Olio, Andrea, Rubert Bassedas, Josep Vicent, San Onofre, Nadia, Scott Jr, W. T., Soriano del Castillo, José Miguel, Taroncher Ferrer, Silvia   +5 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source