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Dimethyl Fumarate vs. Monomethyl Fumarate: Unresolved Pharmacologic Issues [PDF]
PharmaceuticsDimethyl fumarate (DMF) has established a significant position among therapies for multiple sclerosis and psoriasis and is now being investigated for repurposing to many other non-malignant diseases.
Jana Kopincova, Iveta Bernatova
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Combination Treatment of Carboxyl Esterase 2-Overexpressing hTERT-Immortalized Human Adipose Stem Cells Enhances the Inhibition of Tumor Growth by Irinotecan in PC3, a Castration-Resistant Prostate Cancer Model [PDF]
Current Issues in Molecular BiologyCastration-resistant prostate cancer (CRPC) remains difficult to treat with conventional chemotherapy. We evaluated a stem cell-based enzyme-prodrug strategy using hTERT-immortalized adipose-derived stem cells engineered to express rabbit ...
Jae Heon Kim +4 more
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Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2023 Carboxylesterase from edible legume seeds, including black gram bean (Vigna mungo (L.) Hepper), mung bean (Vigna radiata (L.) Wilczek) and red bean (Vigna umbellata (Thunb.) Ohwi and Ohashi) has been partially purified using the ammonium sulphate ...
Chiradet NASUK +2 more
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Carboxylesterase inhibitors [PDF]
Expert Opinion on Therapeutic Patents, 2011 Carboxylesterases play major roles in the hydrolysis of numerous therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety in these small molecules. However, the impact these enzymes may play on drug stability and pharmacokinetics is rarely considered prior to molecule development.
M Jason, Hatfield, Philip M, Potter
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Lipolytic Activity of a Carboxylesterase from Bumblebee (Bombus ignitus) Venom
Toxins, 2021 Bee venom is a complex mixture composed of peptides, proteins with enzymatic properties, and low-molecular-weight compounds. Although the carboxylesterase in bee venom has been identified as an allergen, the enzyme’s role as a venom component has not ...
Yijie Deng +7 more
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Molecules, 2022 Acetyl xylan esterases (AXEs) are enzymes capable of hydrolysing the acetyl bonds in acetylated xylan, allowing for enhanced activity of backbone-depolymerizing enzymes.
Henry Madubuike, Natalie Ferry
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A Fast-Response AIE-Active Ratiometric Fluorescent Probe for the Detection of Carboxylesterase
Biosensors, 2022 Hepatocellular carcinoma (HCC) is associated with a high mortality rate worldwide. The therapeutic outcomes can be significantly improved if diagnosis and treatment are initiated earlier in the disease process.
Mengting Xia +6 more
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Frontiers in Physiology, 2021 Insects rely on their olfactory systems in antennae to recognize sex pheromones and plant volatiles in surrounding environments. Some carboxylesterases (CXEs) are odorant-degrading enzymes (ODEs), degrading odorant signals to protect the olfactory ...
Jiankun Yi +14 more
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Toxins, 2023 Fumonisins (FBs) are mycotoxins that threaten public health and food safety worldwide. Enzymatic degradation of Fumonisin B1 (FB1) through decarboxylation has attracted much attention, whereas application of FB1 carboxylesterase in detoxification ...
Lixiang Jiang +6 more
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Environmental role of aromatic carboxylesterases [PDF]
Environmental Microbiology, 2021 Summary The carboxylesterases (EC 3.1.1.x) are widely distributed and form an important yet diverse group of hydrolases catalysing the ester bond cleavage in a variety of substrates. Besides acting on plant cell wall components like cutin, tannin and feruloyl esters, they are often the first line of defence to metabolize drugs ...
Venkatesh M. Ghodke, Narayan S. Punekar
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