Results 1 to 10 of about 24,285 (160)
Dimethyl Fumarate vs. Monomethyl Fumarate: Unresolved Pharmacologic Issues [PDF]
PharmaceuticsDimethyl fumarate (DMF) has established a significant position among therapies for multiple sclerosis and psoriasis and is now being investigated for repurposing to many other non-malignant diseases.
Jana Kopincova, Iveta Bernatova
doaj +2 more sources
Combination Treatment of Carboxyl Esterase 2-Overexpressing hTERT-Immortalized Human Adipose Stem Cells Enhances the Inhibition of Tumor Growth by Irinotecan in PC3, a Castration-Resistant Prostate Cancer Model [PDF]
Current Issues in Molecular BiologyCastration-resistant prostate cancer (CRPC) remains difficult to treat with conventional chemotherapy. We evaluated a stem cell-based enzyme-prodrug strategy using hTERT-immortalized adipose-derived stem cells engineered to express rabbit ...
Jae Heon Kim +4 more
doaj +2 more sources
Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs [PDF]
Molecular Therapy: Nucleic Acids, 2013 MGH2.1 is a herpes simplex virus type 1 (HSV1) oncolytic virus that expresses two prodrug-activating transgenes: the cyclophosphamide (CPA)-activating cytochrome P4502B1 (CYP2B1) and the CPT11-activating secreted human intestinal carboxylesterase (shiCE).
Kazue Kasai +9 more
doaj +4 more sources
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2023 Carboxylesterase from edible legume seeds, including black gram bean (Vigna mungo (L.) Hepper), mung bean (Vigna radiata (L.) Wilczek) and red bean (Vigna umbellata (Thunb.) Ohwi and Ohashi) has been partially purified using the ammonium sulphate ...
Chiradet NASUK +2 more
doaj +1 more source
Lipolytic Activity of a Carboxylesterase from Bumblebee (Bombus ignitus) Venom
Toxins, 2021 Bee venom is a complex mixture composed of peptides, proteins with enzymatic properties, and low-molecular-weight compounds. Although the carboxylesterase in bee venom has been identified as an allergen, the enzyme’s role as a venom component has not ...
Yijie Deng +7 more
doaj +1 more source
Molecules, 2022 Acetyl xylan esterases (AXEs) are enzymes capable of hydrolysing the acetyl bonds in acetylated xylan, allowing for enhanced activity of backbone-depolymerizing enzymes.
Henry Madubuike, Natalie Ferry
doaj +1 more source
Engineering in Life Sciences, 2022 According to the literature review, microbial degradation of polyethylene terephthalate by PETases has been detected effective and eco‐friendly. However, the number of microorganisms capable of such feats is limited with some undesirable bioprospecting ...
Fatana Lameh +2 more
doaj +1 more source
A Fast-Response AIE-Active Ratiometric Fluorescent Probe for the Detection of Carboxylesterase
Biosensors, 2022 Hepatocellular carcinoma (HCC) is associated with a high mortality rate worldwide. The therapeutic outcomes can be significantly improved if diagnosis and treatment are initiated earlier in the disease process.
Mengting Xia +6 more
doaj +1 more source
Frontiers in Physiology, 2021 Insects rely on their olfactory systems in antennae to recognize sex pheromones and plant volatiles in surrounding environments. Some carboxylesterases (CXEs) are odorant-degrading enzymes (ODEs), degrading odorant signals to protect the olfactory ...
Jiankun Yi +14 more
doaj +1 more source
Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]
, 2010 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert +15 more
core +9 more sources