Results 11 to 20 of about 30,254 (254)
Toxins, 2023 Fumonisins (FBs) are mycotoxins that threaten public health and food safety worldwide. Enzymatic degradation of Fumonisin B1 (FB1) through decarboxylation has attracted much attention, whereas application of FB1 carboxylesterase in detoxification ...
Lixiang Jiang +6 more
doaj +2 more sources
Small-molecule inhibitors of carboxylesterase Notum
Future Medicinal Chemistry, 2021 Notum has recently been identified as a negative regulator of Wnt signaling through the removal of an essential palmitoleate group from Wnt proteins. There are emerging reports that Notum plays a role in human disease, with published data suggesting that
Yuguang Zhao +4 more
semanticscholar +4 more sources
Toxicology Letters, 2021 Carboxylesterases (CES) are an important class of enzymes involved in the hydrolysis of a range of chemicals and show large inter-individual variability in vitro. An extensive literature search was performed to identify in vivo probe substrates for CES1 and CES2 together with their protein content and enzymatic activity. Human pharmacokinetic (PK) data
E. Di Consiglio +7 more
semanticscholar +4 more sources
Evolutionary Applications, 2021 By altering gene expression and creating paralogs, genomic amplifications represent a key component of short‐term adaptive processes. In insects, the use of insecticides can select gene amplifications causing an increased expression of detoxification ...
Julien Cattel +13 more
doaj +2 more sources
Cell Reports, 2017 Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order to ...
Maxwell A. Ruby +9 more
doaj +2 more sources
Advancement of science, 2023 Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis remains a significant challenge due to complex physical environment. Human carboxylesterase (CE) is expected to be a potential biomarker of hepatocellular carcinoma (HCC)
Ying Wen +5 more
semanticscholar +1 more source
ACS Catalysis, 2022 TfCa, a promiscuous carboxylesterase from Thermobifida fusca, was found to hydrolyze polyethylene terephthalate (PET) degradation intermediates such as bis(2-hydroxyethyl) terephthalate (BHET) and mono-(2-hydroxyethyl)-terephthalate (MHET). In this study,
Gerlis von Haugwitz +20 more
semanticscholar +1 more source
A colorimetric fluorescent probe for the detection of carboxylesterase and carbamate pesticides
Analytical Sciences, 2023 A colorimetric fluorescent probe (BTCNA) was developed for the determination of carboxylesterase and carbamate pesticides. The probe used naphthalene–benzothiazole as the fluorescent group and naphthyl acetate as the recognition group.
Jing-Qian Feng +4 more
semanticscholar +1 more source
Carboxylesterase inhibitors [PDF]
Expert Opinion on Therapeutic Patents, 2011 Carboxylesterases play major roles in the hydrolysis of numerous therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety in these small molecules. However, the impact these enzymes may play on drug stability and pharmacokinetics is rarely considered prior to molecule development.
M Jason, Hatfield, Philip M, Potter
openaire +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity. Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of hyperlipidaemia.
Jing Zhang +12 more
semanticscholar +1 more source