Results 141 to 150 of about 27,172,362 (207)

Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1.

International Journal of Biological Macromolecules, 2018
Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors against hCE1 are rarely reported. This study aimed to assess the inhibitory effects of
Ya-Qiao Wang, Zi-miao Weng, Tongyi Dou, Jie Hou, Dan-Dan Wang, Le-le Ding, Li-Wei Zou, Yang Yu, Jing Chen, Hui Tang, Guangbo Ge   +10 more
semanticscholar   +3 more sources

Detection of Carboxylesterase 1 and Chlorpyrifos with ZIF-8 Metal-Organic Frameworks Using a Red Emission BODIPY-Based Probe.

ACS Applied Materials and Interfaces, 2021
In this work, a red emission fluorescent probe CBZ-BOD@zeolitic imidazolate framework-8 (ZIF-8) was fabricated based on metal-organic frameworks (MOFs) for detecting carboxylesterase 1 (CES1).
Baoxing Shen, Chenggong Ma, Yuan Ji, Jianan Dai, Bingzhi Li, Xing Zhang, He Huang   +6 more
semanticscholar   +1 more source

Construction of a red emission fluorescent protein chromophore-based probe for detection of carboxylesterase 1 and carbamate pesticide in culture cells.

Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2021
Designing fluorescent probe for detecting carboxylesterase 1 is remains challenging. Herein, a red emission human carboxylesterase 1 (CES1) probe (CAE-FP) was synthesized based on fluorescent protein chromophore.
Jianan Dai, Yadan Hou, Jichun Wu, Guoyan Zhong, Rui Gao, Baoxing Shen, He Huang   +6 more
semanticscholar   +1 more source

Carbonate‐Based Fluorescent Chemical Tool for Uncovering Carboxylesterase 1 (CES1) Activity Variations in Live Cells

ChemBioChem, 2022
Carboxylesterase 1 (CES1) plays a key role in the metabolism of endogenous biomolecules and xenobiotics including a variety of pharmaceuticals. Despite the established importance of CES1 in drug metabolism, methods to study factors that can vary CES1 ...
Anchal Singh, Mingze Gao, Carolyn J. Karns, Taylor P. Spidle, Michael W. Beck   +4 more
semanticscholar   +1 more source

Detection of carboxylesterase 1 and carbamates with a novel fluorescent protein chromophore based probe

, 2021
An aggregation-induced emission (AIE) fluorescent protein chromophore-based probe (CBZ-FP) for detection of human carboxylesterases (CESs) was designed and synthesized. CBZ-FP exhibited good cell permeability with a large stokes shift (116 nm) and can be
Jianan Dai, Yu Zhao, Yadan Hou, Guoyan Zhong, Rui Gao, Jichun Wu, Baoxing Shen, Xing Zhang   +7 more
semanticscholar   +1 more source

Carboxylesterase 1 and Precision Pharmacotherapy

2021
Carboxylesterase 1 (CES1) is a major phase I drug-metabolizing enzyme, responsible for 80-95% of total hydrolytic activity in human livers. CES1 plays a crucial role in the metabolism of a wide range of drugs, pesticides, environmental pollutants, and endogenous compounds.
openaire   +2 more sources

Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans

Clinical Pharmacology & Therapeutics, 2012
Bioactivation of the antiviral agent oseltamivir to active oseltamivir carboxylate is catalyzed by carboxylesterase 1 (CES1). After the screening of 860 healthy Finnish volunteers for the CES1 c.428G>A (p.Gly143Glu, rs121912777) polymorphism, a pharmacokinetic study with 75 mg oseltamivir was carried out in c.428G>A carriers and noncarriers ...
Tarkiainen E. K., Backman J. T., Niemi Mikko, Neuvonen Mikko Sakari, Neuvonen P. J., Tarkiainen E. K., Backman J. T., Niemi Mikko, Neuvonen Mikko Sakari, Neuvonen P. J.   +9 more
openaire   +3 more sources

Carboxylesterase 1 (CES1) genetic polymorphisms and oseltamivir activation

European Journal of Clinical Pharmacology, 2012
Carboxylesterase 1 (CES1) is the major hepatic hydrolytic enzyme responsible for the metabolism of many therapeutic agents, toxins, and endogenous compounds existing as esters, amides, thioesters, and carbamates. CES1 is coded by the CES1 gene in humans, which consists of three isoforms: CES1A1, CES1A2, and CES1A3.
Hao-Jie, Zhu, John S, Markowitz
openaire   +2 more sources

A magnetic SERS immunosensor for highly sensitive and selective detection of human carboxylesterase 1 in human serum samples.

Analytica Chimica Acta, 2020
Hepatocellular carcinoma (HCC) is a common and lethal cancer. New serum markers for detecting HCC are urgently needed. Human carboxylesterase 1 (hCE1) is an important member of the serine hydrolase superfamily and is closely related to the occurrence of ...
Jun Feng, Yajuan Xu, Wenyi Huang, Hongxing Kong, Yanqing Li, Hao Cheng, Lijun Li   +6 more
semanticscholar   +1 more source

Dexamethasone regulates differential expression of carboxylesterase 1 and carboxylesterase 2 through activation of nuclear receptors

Journal of Huazhong University of Science and Technology [Medical Sciences], 2012
Carboxylesterases (CESs) play important roles in the metabolism of endogenous and foreign compounds in physiological and pharmacological responses. The aim of this study was to investigate the effect of dexamethasone at different doses on the expression of CES1 and CES2.
Chengliang, Zhang, Ping, Gao, Weifeng, Yin, Yanjiao, Xu, Daochun, Xiang, Dong, Liu   +5 more
openaire   +2 more sources