Prediction of Carboxylesterase 1-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models. [PDF]
Drug Metab Dispos, 2022 The use of cannabis products has increased substantially. Cannabis products have been perceived and investigated as potential treatments for attention-deficit/hyperactivity disorder (ADHD).
Qian Y, Markowitz JS.
europepmc +2 more sources
Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRafV600E/Pten-/- mice. [PDF]
Cancer MetabMelanoma is a highly aggressive skin cancer with a poor prognosis. The endocannabinoids 2-arachidonoylgylcerol (2-AG) and anandamide have been linked to melanoma progression, though their roles remain unclear.
Morozova V +3 more
europepmc +2 more sources
Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers. [PDF]
Clin Transl Sci, 2021 Trandolapril, an angiotensin‐converting enzyme inhibitor prodrug, needs to be activated by carboxylesterase 1 (CES1) in the liver to exert its intended therapeutic effect.
Wang X +6 more
europepmc +2 more sources
Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. [PDF]
Drug Metab Dispos, 2022 Carboxylesterase 1 (CES1) is the predominant carboxylesterase in the human liver, involved in metabolism of both xenobiotics and endogenous substrates.
Collins JM +4 more
europepmc +2 more sources
Hepatocyte-Specific Expression of Human Carboxylesterase 1 Attenuates Diet-Induced Steatohepatitis and Hyperlipidemia in Mice. [PDF]
Hepatol Commun, 2020 Rodents have at least five carboxylesterase 1 (Ces1) genes, whereas there is only one CES1 gene in humans, raising the question as to whether human CES1 and mouse Ces1 genes share the same functions.
Xu Y +6 more
europepmc +2 more sources
Liver Carboxylesterase 1 [PDF]
Definitions, 2020 Liver carboxylesterase 1 (567 aa, ~63 kDa) is encoded by the human CES1 gene. This protein plays a role in the catabolism of drugs and aromatic and aliphatic esters.
semanticscholar +2 more sources
In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones. [PDF]
Chem Biol Interact, 2022 Kava refers to the extracts from the rhizome of the plant Piper methysticum which is of particular significance to various indigenous cultures in the South Pacific region. Kavalactones are the active constituents of kava products and are associated with sedative and anxiolytic effects.
Melchert PW +5 more
europepmc +3 more sources
Catalytic Reaction Mechanism for Drug Metabolism in Human Carboxylesterase-1: Cocaine Hydrolysis Pathway. [PDF]
Mol Pharm, 2018 Carboxylesterase-1 (CE-1) is a crucial enzyme responsible for metabolism/activation/inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and organophosphorus nerve agents etc.) and also involved in many other biological processes.
Yao J, Chen X, Zheng F, Zhan CG.
europepmc +2 more sources
Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction. [PDF]
Molecules, 2019 Human carboxylesterase 1 (hCES1) is a major carboxylesterase in the human body and plays important roles in the metabolism of a wide variety of substances, including lipids and drugs, and therefore is attracting more and more attention from areas ...
Yan M +6 more
europepmc +2 more sources
In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites [PDF]
Drug Metabolism and Disposition, 2019 The escalating use of medical cannabis and significant recreational use of cannabis in recent years has led to a higher potential for metabolic interactions between cannabis or one or more of its components and concurrently used medications.
Yuli Qian, Xinwen Wang, J. Markowitz
semanticscholar +3 more sources