Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1. [PDF]
Front Pharmacol, 2017 Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic metabolism.
Zou LW +10 more
europepmc +2 more sources
Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms. [PDF]
Basic Clin Pharmacol Toxicol, 2016 AbstractOseltamivir, an inactive anti‐influenza virus prodrug, is activated (hydrolysed) in vivo by carboxylesterase 1 (CES1) to its active metabolite oseltamivir carboxylate. CES1 functions are significantly associated with certain CES1 genetic variants and some non‐genetic factors. The purpose of this study was to investigate the effect of gender and
Shi J +6 more
europepmc +5 more sources
Correction to "Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators". [PDF]
Drug Metab Dispos, 2020 europepmc +4 more sources
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny [PDF]
Drug Metabolism and Disposition, 2016 Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals. CES1 and CES2 ontogeny has not been well characterized, causing difficulty in addressing concerns regarding juvenile sensitivity to adverse outcomes associated with exposure to certain
Ronald N Hines +2 more
openaire +2 more sources
Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases [PDF]
Journal of Medical Primatology, 2009 AbstractBackground Carboxylesterase (CES) is predominantly responsible for the detoxification of a wide range of drugs and narcotics, and catalyze several reactions in cholesterol and fatty acid metabolism. Studies of the genetic and biochemical properties of primate CES may contribute to an improved understanding of human disease, including ...
Holmes, Roger S +3 more
openaire +3 more sources
Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARγ/RXR and RAR/RXR: down-regulation of CYP27A1-LXRα signaling. [PDF]
Biochem J, 2018 Mangum LC +5 more
europepmc +2 more sources
Weekly irinotecan in a patient with metastatic colorectal cancer on hemodialysis due to chronic renal failure [PDF]
, 2002 Background: The cytotoxic treatment of patients suffering from advanced or metastatic cancer undergoing hemodialysis due to chronic renal failure still remains a problem, since for those patients pharmacokinetic and pharmacodynamic data on most cytotoxic
Hacker, U. +4 more
core +1 more source
The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids [PDF]
, 2012 Fumonisins are mycotoxins frequently found as natural contaminants in maize, where they are produced by the plant pathogen Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid
Bracarense, Ana-Paula +8 more
core +2 more sources
Pharmacogenomic assessment of carboxylesterases 1 and 2
Genomics, 2004 Human carboxylesterases 1 and 2 (CES1 and CES2) catalyze the hydrolysis of many exogenous compounds. Alterations in carboxylesterase sequences could lead to variability in both the inactivation of drugs and the activation of prodrugs. We resequenced CES1 and CES2 in multiple populations (n = 120) to identify single-nucleotide polymorphisms and ...
Sharon, Marsh +7 more
openaire +2 more sources