Results 41 to 50 of about 5,170,686 (370)

Deoxygenative trifluoromethylthiolation of carboxylic acids

open access: yesChemical Science, 2019
A deoxygenative trifluoromethylthiolation method produces trifluoromethyl thioesters from readily available carboxylic acids.
Runze Mao   +3 more
openaire   +5 more sources

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

open access: yesNature Chemical Biology, 2017
Carboxylic acid reductase (CAR) catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes. The enzyme is related to the non-ribosomal peptide synthetases, consisting of an adenylation domain fused via a peptidyl ...
D. Gahloth   +9 more
semanticscholar   +1 more source

Insights into ultrasound-promoted degradation of naphthenic acid compounds in oil sands process affected water. Part I: Accelerated H-abstraction and decarboxylation of aromatic and alicyclic compounds

open access: yesUltrasonics Sonochemistry, 2022
Propelled by enormous increase in demand for fuel sources, Canadian oil sands are becoming increasingly important as a fuel source due to their abundance and upgrading capability.
Rija Ansari, Deepak M. Kirpalani
doaj  

Crystal structure of zymonic acid and a redetermination of its precursor, pyruvic acid

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2019
The structure of zymonic acid (systematic name: 4-hydroxy-2-methyl-5-oxo-2,5-dihydrofuran-2-carboxylic acid), C6H6O5, which had previously eluded crystallographic determination, is presented here for the first time.
Dominik Heger   +3 more
doaj   +1 more source

Mechanistic Insights into the Enantioselective Epoxidation of Olefins by Bioinspired Manganese Complexes: Role of Carboxylic Acid and Nature of Active Oxidant

open access: yes, 2018
Bioinspired manganese and iron complexes bearing nonporphyrinic tetradentate N4 ligands are highly efficient catalysts in asymmetric oxidation reactions by hydrogen peroxide (H2O2), in which carboxylic acid is employed as an essential additive to improve
Junyi Du   +6 more
semanticscholar   +1 more source

Recent Advances in the Synthesis of Carboxylic Acid Esters

open access: yesCarboxylic Acid - Key Role in Life Sciences, 2018
In this chapter, recent advances in the synthesis of carboxylic acid esters are summarized based on the utilization of carboxylic acids as electrophiles or nucleophiles in reactions.
Kouichi Matsumoto, Rina Yanagi, Y. Oe
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Crystal structure of [1,1′:3′,1′′-terphenyl]-2′,3,3′′-tricarboxylic acid

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2015
The asymmetric unit of the title compound, C21H14O6, comprises two symmetrically independent molecules that form a locally centrosymmetric hydrogen-bonded dimer, with the planes of the corresponding carboxylic acid groups rotated by 15.8 (1) and 17.5 (1)°
Daniel A. Decato, Orion B. Berryman
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Total lineshape analysis of α-tetrahydrofuroic acid $^{1}$H NMR spectra [PDF]

open access: yesarXiv, 2022
The 1H NMR spectra of L-proline oxygen analogous, alpha-tetrahydrofuroic acid, 7-spins nonsymmetric spin system with strongly pronounced non-first order effects were analyzed by ANATOLIA total lineshape fitting. A close agreement of theoretical and experimental spectra (with R-Factor values bellow 5%) was achieved and accurate values of coupling ...
arxiv  

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