Results 91 to 100 of about 5,868 (229)

Methods and pharmaceutical compositions for treating tubulin carboxypeptidases associated diseases.

, 2019
Using chemical proteomics with a potent unique irreversible inhibitor, inventors found that major brain tubulin carboxypeptidase (TCP)is a complex of vasohibin-1 (VASH1) with the Small Vasohibin-Binding Protein (SVBP). VASH1 and its homologue vasohibin-2
Andrieux, Annie, Bosc, Christophe, Peris, Leticia, Delagrange, Philippe, Moutin, M.-J., Aillaud, Chrystelle   +5 more
core   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1300-1311, July 2026.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides

, 2012
Here we report the isolation of carboxypeptidases A1 and A2 (CPA1 and CPA2) from the rat mesenteric arterial bed perfusate, which were found to be identical with their pancreatic counterparts.
Hugo J.V. Pereira, Laura L. Souza, Claudio M. Costa-Neto, Pereira, Hugo J.V., Maria Cristina O. Salgado, Souza, Laura L., Oliveira, Eduardo B., Costa Neto, Claudio Miguel da, Costa-Neto, Claudio M., Pereira, Hugo J. V., Salgado, Maria Cristina O., Eduardo B. Oliveira   +11 more
core   +1 more source

A European consensus recommendation on the management of delayed methotrexate elimination: supportive measures, leucovorin rescue and glucarpidase treatment

Journal of Cancer Research and Clinical Oncology
High-dose methotrexate (HDMTX) is used in the treatment of a range of adult and childhood cancers. Although HDMTX can provide effective anti-tumor activity with an acceptable safety profile for most patients, delayed methotrexate elimination (DME ...
Stefan S. Bielack, Carole Soussain, Christopher P. Fox, Caroline Houillier, Thais Murciano, Wendy Osborne, Pier Luigi Zinzani, Carmelo Rizzari, Stefan Schwartz   +8 more
doaj   +1 more source

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Mast Cells in Acute COVID‐19 Patients

Allergy, EarlyView.
Ilan Zaffran, Hadas Pahima, Eli Ben‐Chetrit, Amir Jarjoui, Ilaria Puxeddu, Carl Zinner, Joana Vitte, Alexandar Tzankov, Francesca Levi‐Schaffer   +8 more
wiley   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, Volume 26, Issue 7, Page 69-83, July 2026.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Tissue carboxypeptidases activity of the women w ith womb body oncopathology

, 2004
Досліджена активність карбоксипептидаз А і В доброякісних та злоякісних новоутворень тіла матки. Встановлено, що у доброякісних новоутвореннях активність карбоксипептидаз змінюється в залежності від проліферуючого потенціалу пухлинних клітин міометрія та
Блохін, Ю. В., Вовчук, Iрина Леонiдiвна, Раздражнюк, Г. С., Чернадчук, Снежана Сергеевна, Vovchuk, Iryna L., Блохин, Ю. В., Razdrazhnuk, G. S., Чернадчук, Сніжана Сергіївна, Вовчук, Ирина Леонидовна, Chernadchuk, Snizhana S., Blohin, U. V.   +10 more
core  

Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase-activated B2 receptor agonists

Frontiers in Pharmacology, 2014
While bradykinin (BK) is known to be degraded by angiotensin converting enzyme (ACE), we have recently discovered that Met-Lys-BK-Ser-Ser is paradoxically activated by ACE.
Xavier eCharest-Morin, Caroline eRoy, Émile-Jacques eFortin, Johanne eBouthillier, François eMarceau   +4 more
doaj   +1 more source