Results 101 to 110 of about 5,868 (229)

Radiolabeled Angiopep‐2 Peptide Vector as a Preclinical Platform for Blood–Brain Barrier Targeting: Synthesis, Radiolabeling, and Preliminary In Vivo Biodistribution in Mice

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
The developed DOTA‐Angiopep‐2 conjugate was well tolerated in glioma cells and enabled high‐yield radiolabeling with 177Lu and 161Tb. The 161Tb conjugate showed brain delivery with predominantly renal clearance, supporting a stable radiotheranostic platform for BBB‐targeted glioma therapy and SPECT imaging.
Evgenia Fotou, Adamantia Apostolopoulou, Christina‐Georgia Bika, Maria Giannakopoulou, Danai‐Efraimia Bajwa, Vassilios Moussis, Vassilios Tsikaris, Ioannis P. Gerothanassis, George A. Alexiou, Penelope Bouziotis, Andreas G. Tzakos   +10 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode

, 2005
The tick carboxypeptidase inhibitor (TCI) is a proteinaceous inhibitor of metallo-carboxypeptidases present in the blood-sucking tick Rhipicephalus bursa.
Huber, Robert, Aviles, Francesc X., Aviles, F. X., Popowicz, G. M., Sornmerhoff, C. P., Huber, R., Popowicz, Grzegorz M., Arolas, Joan L., Sommerhoff, Christian P., Holak, Tad A., Holak, T. A., Arolas, J. L., Lorenzo, Julia, Lorenzo, J.   +13 more
core   +1 more source

A Preliminary Study of the Activation of Endogenous Pancreatic Exocrine Enzymes during Automated Porcine Islet Isolation

Cell Transplantation, 1999
The activation of endogenous pancreatic enzymes during automated pancreas digestion may be detrimental to islet isolation. In this report we assessed the activation of trypsin, chymotrypsin, elastase, carboxypeptidases A and B, phospholipase A 2 , and ...
S. A. White MD, FRCS, H. Djaballah, D. P. Hughes, D. L. Roberts, H. H. Contractor, S. Pathak, N. J. M. London   +6 more
doaj   +1 more source

Cereal carboxypeptidases : occurrence, properties and possible functions

In cereal grains the bulk of reserve proteins is localized in the non-living storage tissue, the starchy endosperm. In this work, it was found that the starchy endosperm of barley grain contained high activities of serine carboxypeptidases (EC 3.4.16 ...
Mikola, Leena
core  

Zebrafish Cytosolic Carboxypeptidases 1 and 5 Are Essential for Embryonic Development

, 2013
The cytosolic carboxypeptidases (CCPs) are a subfamily of metalloenzymes within the larger M14 family of carboxypeptidases that have been implicated in the post-translational modification of tubulin.
Fricker, Lloyd D., Sapio, Matthew R., Lyons, Peter J.   +2 more
core  

Human glutamate carboxypeptidases II and III

, 2016
The herein presented Ph.D. dissertation describes kinetic and structural characterization of human glutamate carboxypeptidases II and III (GCPII and GCPIII) using a complete panel of their natural substrates.
Navrátil, Michal
core  

Identification of Tubulin Deglutamylase among Caenorhabditis elegans and Mammalian Cytosolic Carboxypeptidases (CCPs)

, 2010
Tubulin polyglutamylation is a reversible post-translational modification, serving important roles in microtubule (MT)-related processes. Polyglutamylases of the tubulin tyrosine ligase-like (TTLL) family add glutamate moieties to specific tubulin ...
Mitsutoshi Setou, Konishi, Y., Kunitomo, H., Nobuya Kurabe, Iino, Y., Tsutsumi, K., Hirofumi Kunitomo, Yoshishige Kimura, Blacque, O.E., Ikegami, K., Koji Ikegami, Koji Tsutsumi, Yoshiyuki Konishi, Setou, M., Oktay Ismail Kaplan, Kaplan, O.I., Yuichi Iino, Oliver E. Blacque, Kimura, Y., Kurabe, N.   +19 more
core   +1 more source

Serine carboxypeptidases of Triatoma brasiliensis (Hemiptera, Reduviidae): Sequence characterization, expression pattern and activity localization

, 2014
Using specific oligonucleotides, 50- and 30-RACE and sequencing, two cDNAs encoding serine carboxypeptidases (tbscp-1 and tbscp-2) from the midgut of the blood sucking heteropteran Triatoma brasiliensis were identified.
Waniek, Peter J, Momoli, Marisa M, Araújo, Catarina A. C, Azambuja, Patricia, Genta, Fernando A, Jansen, Ana Maria   +5 more
core  

Bacteria detection based on the evolution of enzyme-generated volatile organic compounds: Determination of Listeria monocytogenes in milk samples

, 2014
The rapid detection of Listeria monocytogenes contamination in food is essential to prevent food-borne illness in humans. The aim of this study was to differentiate non-contaminated milk from milk contaminated with L.
Dean, John, Stanforth, Stephen, Tait, Emma, Perry, John   +3 more
core   +1 more source