Results 81 to 90 of about 84,483 (336)

The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients [PDF]

, 2018
Background: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable.
A Celeghin, A Habr-Gama, AL Appelt, Alessandro Perin, AM Mandard, Angela Buonadonna, Anita De Rossi, Antonino De Paoli, C Alix-Panabières, C Belluco, Caterina Boso, Claudio Belluco, D Beddy, D Hanahan, D Lin, D Tural, E Rampazzo, E Rampazzo, E Rampazzo, EH Blackburn, Elisa Palazzari, Enrica Rampazzo, Francesca Bergamo, G Saretzki, G Spolverato, Giovanna Spiro, I Gingras, J Buijsen, J Maláska, JA March-Villalba, JF Bosset, JM Lewis, JP Gerard, K Bujko, K Kojima, L Moureau-Zabotto, L Terrin, L Terrin, LA Torre, M Maas, M Spornraft, MB Amin, MS Roh, N Miura, N Tani, P Boscolo-Rizzo, Paola Del Bianco, R Bertorelle, R Bertorelle, R Sauer, R Siegel, RK Deblakshmi, Roberta Bertorelle, S Giunco, S Pucciarelli, S Pucciarelli, Salvatore Pucciarelli, Sara Leonardi, SB Edge, SH Lim, SM Lledó, T El-Hefnawy, Y Kang   +62 more
core   +1 more source

Biosynthesis and glycosylation of the carcinoembryonic antigen [PDF]

Biochemical Journal, 1988
Human gastric adenocarcinoma MKN-45 cells were found to synthesize actively carcinoembryonic antigen (CEA). The biosynthesis and carbohydrate processing of CEA were studied in these cells by means of metabolic labelling followed by immunoadsorption with a specific polyclonal-antibody preparation and gel electrophoresis.
P Lorenzoni, C Mottola-Hartshorn, C Ceccarini   +2 more
openaire   +3 more sources

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

Advanced Science, EarlyView.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen, Keying Zhu, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Min Yang   +8 more
wiley   +1 more source

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses [PDF]

, 2015
Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies.
arxiv   +1 more source

The Carcinoembryonic Antigen (CEA): Past, Present, and Future

McGill Journal of Medicine, 2020
N ...
Phil Gold, Neil Goldberg
doaj   +1 more source

AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis

Advanced Science, EarlyView.
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu, Amarnath Marudamuthu, Khadija Kakar, Hamida Hamida, Shruthi Thada, Rohan Gupta, Kiesha Wilson, Taylor Carter, Yin Zhong, Archana Saxena, Xiaoming Yang, Narendra Singh, Philip Brandon Busbee, Jie Li, Monica Garcia‐Buitrago, Prakash Nagarkatti, Mitzi Nagarkatti   +16 more
wiley   +1 more source

Computational model for tumor response to adoptive cell transfer therapy [PDF]

arXiv, 2022
One of the barriers to the development of effective adoptive cell transfer therapies (ACT), specifically for genetically engineered T-cell receptors (TCRs), and chimeric antigen receptor (CAR) T-cells, is target antigen heterogeneity. It is thought that intratumor heterogeneity is one of the leading determinants of therapeutic resistance and treatment ...
arxiv  

Convergent evolution of pregnancy-specific glycoproteins in human and horse [PDF]

, 2016
Pregnancy-specific glycoproteins (PSGs) are members of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family that are secreted by trophoblast cells. PSGs may modulate immune, angiogenic and platelet responses during pregnancy.
Amanda M de Mestre, Baker, Denis Aleksic, Donaldson, Fialova, Jana Hänske, Johannes Handler, Jordan E Read, Lisa Blaschke, Robert Kammerer, Ronan O’Riordan, Schumacher, Sophie Mißbach, Tom Moore, Victoria Cabrera-Sharp, Wiebke Weiß, Wolfgang Zimmermann   +16 more
core   +1 more source

Rapid and Noninvasive Early Detection of Lung Cancer by Integration of Machine Learning and Salivary Metabolic Fingerprints Using MS LOC Platform: A Large‐Scale Multicenter Study

Advanced Science, EarlyView.
Salivary metabolic signatures associated with lung cancer are systematically characterized through a self‐developed high‐throughput mass spectrometry Lab‐on‐a‐Chip platform. Utilizing these metabolic fingerprints, SalivaMLD, an integrated machine‐learning‐driven classification model is developed and demonstrates superior performance in detecting lung ...
Shuang Lin, Runlan Yan, Junqi Zhu, Bei Li, Yinyan Zhong, Shuang Han, Huiting Wang, Jianmin Wu, Zhao Chen, Yuyue Jiang, Aiwu Pan, Xuqing Huang, Xiaoming Chen, Pingya Zhu, Sheng Cao, Wenhua Liang, Peng Ye, Yue Gao   +17 more
wiley   +1 more source

Sequence-Based Nanobody-Antigen Binding Prediction [PDF]

arXiv, 2023
Nanobodies (Nb) are monomeric heavy-chain fragments derived from heavy-chain only antibodies naturally found in Camelids and Sharks. Their considerably small size (~3-4 nm; 13 kDa) and favorable biophysical properties make them attractive targets for recombinant production.
arxiv