Results 1 to 10 of about 280,367 (274)

In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer

BMC Urology, 2021
Background WW Domain Containing Oxidoreductase (WWOX) belongs to the unusual tumor suppressors, whose molecular function is not fully understood in bladder cancer, especially regarding interaction with Activator Protein 2 (AP-2) α/γ transcription factors.
Żaneta Kałuzińska, Damian Kołat, Katarzyna Kośla, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik   +5 more
doaj   +1 more source

Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma

Scientific Reports, 2021
Treatment effectiveness in hepatocellular carcinoma (HCC) depends on early detection and precision-medicine-based patient stratification for targeted therapies.
Yotsawat Pomyen, Anuradha Budhu, Jittiporn Chaisaingmongkol, Marshonna Forgues, Hien Dang, Mathuros Ruchirawat, Chulabhorn Mahidol, Xin Wei Wang, the TIGER-LC Consortium   +8 more
doaj   +1 more source

Prognostic significance of AP-2α/γ targets as cancer therapeutics

Scientific Reports, 2022
Identifying genes with prognostic importance could improve cancer treatment. An increasing number of reports suggest the existence of successful strategies based on seemingly “untargetable” transcription factors.
Damian Kołat, Żaneta Kałuzińska, Andrzej K. Bednarek, Elżbieta Płuciennik   +3 more
doaj   +1 more source

Functional genomics of AP-2α and AP-2γ in cancers: in silico study

BMC Medical Genomics, 2020
Background Among all causes of death, cancer is the most prevalent and is only outpaced by cardiovascular diseases. Molecular theory of carcinogenesis states that apoptosis and proliferation are regulated by groups of tumor suppressors or oncogenes ...
Damian Kołat, Żaneta Kałuzińska, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik   +4 more
doaj   +1 more source

Expression and Significance of AQP3 in Cutaneous Lesions

Analytical Cellular Pathology, 2021
Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions.
Dongfeng Niu, Yanhua Bai, Qian Yao, Wei Hou, Lixin Zhou, Xiaozheng Huang, Chen Zhao   +6 more
doaj   +1 more source

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells

Molecular Cancer, 2020
Background Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements are required.
Nan Zhang, Aruo Nan, Lijian Chen, Xin Li, Yangyang Jia, Miaoyun Qiu, Xin Dai, Hanyu Zhou, Jialu Zhu, Han Zhang, Yiguo Jiang   +10 more
doaj   +1 more source

Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer

Molecular Cancer, 2019
Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer.
Lijian Chen, Aruo Nan, Nan Zhang, Yangyang Jia, Xin Li, Yihui Ling, Jiabin Dai, Shaozhu Zhang, Qiaoyuan Yang, Yanni Yi, Yiguo Jiang   +10 more
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Concentration and isolation of DNA from biological fluids by agarose gel isotachophoresis

BioTechniques, 2005
Isotachophoresis is an electrophoretic method of separation of charged substances. The method is characterized by a discontinuous buffer system, constant velocity of separated molecules, and the distribution of separated components in the form of narrow ...
Valentina N. Kondratova, Ol'ga I. Serd'uk, Valery P. Shelepov, Anatoly V. Lichtenstein   +3 more
doaj   +1 more source

The AT-hook is an evolutionarily conserved auto-regulatory domain of SWI/SNF required for cell lineage priming

Nature Communications, 2023
The SWI/SNF ATP-dependent chromatin remodeler is a master regulator of the epigenome, controlling pluripotency and differentiation. Towards the C-terminus of the catalytic subunit of SWI/SNF is a motif called the AT-hook that is evolutionary conserved ...
Dhurjhoti Saha, Solomon Hailu, Arjan Hada, Junwoo Lee, Jie Luo, Jeff A. Ranish, Yuan-chi Lin, Kyle Feola, Jim Persinger, Abhinav Jain, Bin Liu, Yue Lu, Payel Sen, Blaine Bartholomew   +13 more
doaj   +1 more source

Modeling age-specific incidence of colon cancer via niche competition [PDF]

PLoS Comput Biol 18(8): e1010403 (2022), 2021
Cancer development is a multistep process often starting with a single cell in which a number of epigenetic and genetic alterations have accumulated thus transforming it into a tumor cell. The progeny of such a single benign tumor cell expands in the tissue and can at some point progress to malignant tumor cells until a detectable tumor is formed.
arxiv   +1 more source