Results 1 to 10 of about 385,377 (294)

Neutrophils in cancer carcinogenesis and metastasis

Journal of Hematology & Oncology, 2021
In recent years, neutrophils have attracted increasing attention because of their cancer-promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic indicator for patients with cancer.
Shumin Xiong, Liaoliao Dong, Lin Cheng
semanticscholar   +1 more source

The role of bile acids in carcinogenesis

Cellular and Molecular Life Sciences, 2022
Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently undergo bacterial transformation yielding a diverse array of metabolites.
T. Režen, D. Rozman, T. Kovács, Patrik Kovács, A. Sipos, P. Bai, E. Mikó   +6 more
semanticscholar   +1 more source

In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer

BMC Urology, 2021
Background WW Domain Containing Oxidoreductase (WWOX) belongs to the unusual tumor suppressors, whose molecular function is not fully understood in bladder cancer, especially regarding interaction with Activator Protein 2 (AP-2) α/γ transcription factors.
Żaneta Kałuzińska, Damian Kołat, Katarzyna Kośla, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik   +5 more
doaj   +1 more source

Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma

Scientific Reports, 2021
Treatment effectiveness in hepatocellular carcinoma (HCC) depends on early detection and precision-medicine-based patient stratification for targeted therapies.
Yotsawat Pomyen, Anuradha Budhu, Jittiporn Chaisaingmongkol, Marshonna Forgues, Hien Dang, Mathuros Ruchirawat, Chulabhorn Mahidol, Xin Wei Wang, the TIGER-LC Consortium   +8 more
doaj   +1 more source

Functional genomics of AP-2α and AP-2γ in cancers: in silico study

BMC Medical Genomics, 2020
Background Among all causes of death, cancer is the most prevalent and is only outpaced by cardiovascular diseases. Molecular theory of carcinogenesis states that apoptosis and proliferation are regulated by groups of tumor suppressors or oncogenes ...
Damian Kołat, Żaneta Kałuzińska, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik   +4 more
doaj   +1 more source

Prognostic significance of AP-2α/γ targets as cancer therapeutics

Scientific Reports, 2022
Identifying genes with prognostic importance could improve cancer treatment. An increasing number of reports suggest the existence of successful strategies based on seemingly “untargetable” transcription factors.
Damian Kołat, Żaneta Kałuzińska, Andrzej K. Bednarek, Elżbieta Płuciennik   +3 more
doaj   +1 more source

Expression and Significance of AQP3 in Cutaneous Lesions

Analytical Cellular Pathology, 2021
Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions.
Dongfeng Niu, Yanhua Bai, Qian Yao, Wei Hou, Lixin Zhou, Xiaozheng Huang, Chen Zhao   +6 more
doaj   +1 more source

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Molecular Cancer, 2020
The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis ...
Hui Yang, Qiannan Zhang, Miao Xu, Lei Wang, Xuewei Chen, Yongquan Feng, Yongning Li, Xin Zhang, W. Cui, X. Jia   +9 more
semanticscholar   +1 more source

Chemical carcinogenesis [PDF]

Anais da Academia Brasileira de Ciências, 2007
The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs to be produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increase in levels of life expectancy.
Oliveira, Paula A., Colaço, Aura, Guedes-Pinto, Henrique, De-La-Cruz P., Luis F., Lopes, Carlos, Chaves, Raquel   +5 more
openaire   +6 more sources

Carcinogenesis of PIK3CA [PDF]

Hereditary Cancer in Clinical Practice, 2013
Abstract PIK3CA is the most frequently mutated oncogene in human cancers. PIK3CA is phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha. It controls cell growth, proliferation, motility, survival, differentiation and intracellular trafficking.
Sidra German, Arsalan Ahmad Alvi, Aisha Raees, Hafiz Muhammad Aslam, Shafaq Saleem, Tooba Anum, Abdul Haseeb   +6 more
openaire   +3 more sources