Results 11 to 20 of about 262,585 (248)

LINC01137/miR-186-5p/WWOX: a novel axis identified from WWOX-related RNA interactome in bladder cancer

Frontiers in Genetics, 2023
Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions.
Damian Kołat, Żaneta Kałuzińska-Kołat, Katarzyna Kośla, Magdalena Orzechowska, Elżbieta Płuciennik, Andrzej K. Bednarek   +5 more
doaj   +1 more source

P85

EJC Supplements, 2015
Glucocorticoids (GCs) are the most important component of therapy for a number of diseases including combined chemotherapy of hematological malignancies. However, their application is strongly restricted by the development of serious side effects as well
L. Tilova, O. Zadorozhnaya, A. Savinkova, K. Kirsanov, A. Ogloblina, G. Belitsky, I. Budunova, E. Lesovaya, M. Yakubovskaya   +8 more
doaj   +1 more source

M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway

World Journal of Surgical Oncology, 2018
Background M2-polarized macrophages are tumor-associated-macrophages (TAMs), which are important contents of tumor-infiltrating immune cells. Toll-like receptor 4 (TLR4) is a molecular biomarker of tumor aggressiveness and poor prognosis.
Rong-Rong Yao, Jing-Huan Li, Rui Zhang, Rong-Xin Chen, Yan-Hong Wang   +4 more
doaj   +1 more source

Circular RNA 406961 interacts with ILF2 to regulate PM2.5-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways

Environment International, 2020
Fine particulate matter (PM2.5) has been verified to augmented the incidence of pneumonia, asthma, pulmonary fibrosis, and other pulmonary diseases. Airway inflammation is the pathological basis of the respiratory system, and understanding the molecular ...
Yangyang Jia, Xin Li, Aruo Nan, Nan Zhang, Lijian Chen, Hanyu Zhou, Han Zhang, Miaoyun Qiu, Jialu Zhu, Yihui Ling, Yiguo Jiang   +10 more
doaj   +1 more source

X or Y Cancer: An Extensive Analysis of Sex Differences in Lung Adenocarcinoma

Current Oncology, 2023
Background: Cellular metabolism is a tightly controlled process during which cell growth and survival are maintained. Lung cancer is a disease with clear sex differences, where female patients have better survival rates than males.
Raneem Yaseen Hammouz, Magdalena Orzechowska, Dorota Anusewicz, Andrzej K. Bednarek   +3 more
doaj   +1 more source

Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity

Biological Research, 2019
Background Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) cells is still unclear.
Wenting Wang, Mingyue Zhu, Zhixin Xu, Wei Li, Xu Dong, Yi Chen, Bo Lin, Mengsen Li   +7 more
doaj   +1 more source

A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer

Scientific Reports, 2021
Resistance to drugs targeting the androgen receptor (AR) signaling axis remains an important challenge in the treatment of prostate cancer patients. Activation of alternative growth pathways is one mechanism used by cancer cells to proliferate despite ...
Sander A. L. Palit, Jeroen van Dorp, Daniel Vis, Cor Lieftink, Simon Linder, Roderick Beijersbergen, Andries M. Bergman, Wilbert Zwart, Michiel S. van der Heijden   +8 more
doaj   +1 more source

Nickel carcinogenesis [PDF]

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2003
Human exposure to highly nickel-polluted environments, such as those associated with nickel refining, electroplating, and welding, has the potential to produce a variety of pathologic effects. Among them are skin allergies, lung fibrosis, and cancer of the respiratory tract.
Kazimierz S, Kasprzak, F William, Sunderman, Konstantin, Salnikow   +2 more
openaire   +2 more sources

Author Correction: De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Wei He, Liang Zhang, Oscar D. Villarreal, Rongjie Fu, Ella Bedford, Jingzhuang Dou, Anish Y. Patel, Mark T. Bedford, Xiaobing Shi, Taiping Chen, Blaine Bartholomew, Han Xu   +11 more
doaj   +1 more source

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

Nature Communications, 2017
MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein ...
Can Liu, Ruifang Liu, Dingxiao Zhang, Qu Deng, Bigang Liu, Hsueh-Ping Chao, Kiera Rycaj, Yoko Takata, Kevin Lin, Yue Lu, Yi Zhong, John Krolewski, Jianjun Shen, Dean G. Tang   +13 more
doaj   +1 more source