Results 231 to 240 of about 14,534 (309)

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Antibacterial activity, phytochemical profiling and ADMET prediction of bioactive compounds in Origanum syriacum and Salix alba. [PDF]

Sci Rep
Basudan NS, El-Hefnawy AA, El-Sapagh S, El-Sayed MN, Saad-Allah KM, Azab M.   +5 more
europepmc   +1 more source

Inline Oxygenation in Drip‐Irrigated Citrus: How Much Agrochemical Reduction Is Needed to Achieve Net Environmental Benefits?

Irrigation and Drainage, EarlyView.
ABSTRACT The agronomic benefits of oxygen‐enriched irrigation, such as improved root development, enhanced nutrient uptake, and reduced fertiliser and pesticide requirements, are well documented. However, incorporating oxygenation devices into fertigation systems increases energy demand and material use, thereby incurring additional environmental ...
Alberto Imbernón‐Mulero, Saker Ben Abdallah, Mohamed Zied Dhraief, Jose F. Maestre‐Valero, Belén Gallego‐Elvira   +4 more
wiley   +1 more source

Detailed hazard assessment of ethylbenzene to establish an indoor air quality guideline in Japan. [PDF]

Environ Health Prev Med
Inoue K, Hirabayashi Y, Azuma K.
europepmc   +1 more source

Miniaturized Droplet‐Based Adaptation of the Ames Test for High‐Throughput Mutagenicity Assessment

Journal of Applied Toxicology, EarlyView.
ABSTRACT This work presents the first demonstration of a tube‐based droplet microfluidic implementation of the Ames test, bridging single‐droplet resolution with regulatory genotoxicity testing. The Ames test is a cornerstone assay for detecting mutagenicity, but conventional plate‐ and well‐based formats suffer from high reagent consumption, low ...
Jialan Cao, Bayan Nasr, J. Michael Köhler, Sebastian Buchinger   +3 more
wiley   +1 more source

Perspective on applicability of data-driven machine learning computational new approach methodologies for hazard identification in chemicals risk assessment. [PDF]

J Cheminform
Piir G, Sild S, Tcheremenskaia O, Di Consiglio E, Henriksson J, Gajewicz-Skretna A, Mombelli E, Roncaglioni A, Maran U.   +8 more
europepmc   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

Variability and uncertainty of data from genotoxicity test guidelines: what we know and why it matters. [PDF]

Arch Toxicol
Raitano G, Pronk TE, Battistelli CL, Bossa C, Hatzi V, Nikolopoulou D, Chaideftou E, Tcheremenskaia O, Adam-Guillermin C, Audebert M, Mertens B, Paparella M.   +11 more
europepmc   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Review of Health Hazards in High-Entropy Alloy Processing Under Laboratory Conditions and Risk Assessment Using a Simple Risk Scoring Model. [PDF]

Toxics
Dewangan SK.
europepmc   +1 more source