Results 231 to 240 of about 89,882 (308)

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

High FGFR4 protein expression, but not FGFR1 or FGFR2, predicts poor prognosis in pancreatic ductal adenocarcinoma. [PDF]

BMC Cancer
Braun M, Durślewicz J, Sołek J, Nowicka Z, Zielińska A, Antosik P, Grzanka D.   +6 more
europepmc   +1 more source

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
wiley   +1 more source

Case report: metachronous male metastatic breast and colon cancer in a BRCA2 mutation carrier. [PDF]

Discov Oncol
Larionesi E, Pilet ON, Sotiriou C.
europepmc   +1 more source

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source

Pancreaticobiliary fistula associated with intraductal papillary mucinous neoplasm and the simultaneous ampullary carcinoma: A case report. [PDF]

Medicine (Baltimore)
Itagaki Y, Sato S, Omori Y, Yamamoto H, Kimura K, Kushiya H, Tsunetoshi Y, Kato K, Takada M, Ambo Y, Ota S, Hirano S.   +11 more
europepmc   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Long-Term Outcomes of EUS-Guided Pancreatic Duct Drainage for the Management of Benign Pancreaticojejunostomy Anastomotic Stricture-A Retrospective Cohort Study. [PDF]

J Clin Med
Melianti I, Hara K, Kuwahara T, Haba S, Okuno N, Matsumoto S, Koda H, Oshiro K, Ogata T.   +8 more
europepmc   +1 more source

Revisiting Clonal Evolution Through the Light of Retrotransposons

BioEssays, Volume 47, Issue 12, December 2025.
We propose integrating retrotransposons into the clonal evolution model of cancer. Retrotransposons can modulate cancer cell fitness, potentially influencing clonal dynamics. They might also induce lineage violations via cell fusion or horizontal transfer.
Anaïs Lamoureux, Emilie Elvira‐Matelot, Françoise Porteu, Lucie Laplane   +3 more
wiley   +1 more source

Extended Survival with Pancreatic Carcinosarcoma: A Case Report and Literature Review. [PDF]

Curr Oncol
Xiao T, Browne C, Black M, Marginean C, Tsvetkova E.   +4 more
europepmc   +1 more source