Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo [PDF]
, 2013 Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents.
Eva Juengel +13 more
core +2 more sources
Synchronous bilateral renal cell carcinomas with differing histologies
IJU Case Reports, 2020 Introduction Bilateral renal cell carcinomas with different histological types are rare. We report herein the first description of bilateral renal carcinomas with clear cell renal cell carcinoma and mucinous tubular and spindle cell carcinoma occurring ...
Ryu Shigehisa +9 more
doaj +1 more source
Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells [PDF]
, 2009 Background Treatment options for metastatic renal cell carcinoma (RCC) are limited due to resistance to chemo- and radiotherapy. The development of small-molecule multikinase inhibitors have now opened novel treatment options.
Natsheh, Iyad Y. M. +15 more
core +2 more sources
Significance of chromosome 9p status in renal cell carcinoma:a systematic review and quality of the reported studies [PDF]
, 2014 Defining the prognosis of renal cell carcinoma (RCC) using genetic tests is an evolving area. The prognostic significance of 9p status in RCC, although described in the literature, remains underutilised in clinical practice. The study explored the causes
El-Mokadem, Ismail +6 more
core +1 more source
Temsirolimus for patients with metastatic renal cell carcinoma : outcomes in patients receiving temsirolimus within a compassionate use program in a tertiary referral center [PDF]
, 2014 Aim: Temsirolimus has shown efficacy as first-line treatment of patients with metastatic renal cell carcinoma and poor prognostic features. The efficacy of temsirolimus in other clinical settings, such as second-line therapy, is unclear.
Pascoe, Jennifer +4 more
core +1 more source
Large renal artery aneurysm masquerading as renal cell carcinoma
, 2022 Renal artery aneurysms (RAAs) are rare. Diagnosis is typically incidental with most cases asymptomatic and detected on routine imaging. Rarely large saccular RAAs may appear to extend to the neighbouring renal parenchyma. Differentiating these from renal
Desai, Devang +4 more
core +1 more source
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways [PDF]
, 2013 The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known ...
Ashcroft, M +4 more
core +2 more sources
The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo [PDF]
, 2008 Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical ...
Eva Juengel +13 more
core +1 more source
Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma
Tumor Biology, 2017 Lactate dehydrogenase C is an isoenzyme of lactate dehydrogenase and a member of the cancer–testis antigens family. In this study, we aimed to investigate the expression and functional role of lactate dehydrogenase C and its basic mechanisms in renal ...
Yibo Hua +12 more
doaj +1 more source
Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma [PDF]
, 2010 Background: The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression and prognosis in patients with
Johannes Hüsing +29 more
core +2 more sources