Results 41 to 50 of about 306,294 (257)

STEAP3 Affects Ferroptosis and Progression of Renal Cell Carcinoma Through the p53/xCT Pathway

Technology in Cancer Research & Treatment, 2022
Renal cell carcinoma is particularly sensitive to ferroptosis, an iron-dependent non-apoptotic form of cell death. This mechanism does not require activation of caspase or the participation of other apoptotic effector molecules (such as BAX or BAK), nor ...
Cheng Lin Ye MS, Yang Du MD, Xi Yu MD, Zhi Yuan Chen MD, Lei Wang MD, Yong Fa Zheng MD, Xiu Heng Liu MD   +6 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Exosome in renal cell carcinoma progression and implications for targeted therapy

Frontiers in Oncology
Renal cell carcinoma is a urological malignancy with a high metastatic rate, while targeted therapy for renal cell carcinoma still has much room for improvement.
Xinwei Li, Xinwei Li, Wen Xiao, Wen Xiao, Hongmei Yang, Xiaoping Zhang, Xiaoping Zhang, Xiaoping Zhang   +7 more
doaj   +1 more source

Clinicopathologic features of renal cell carcinomas seen at the Aga Khan University Hospital in Kenya

Frontiers in Medicine, 2022
IntroductionKidney cancer accounted for 1. 8% of global cancer deaths according to Globocan 2020 estimates, with most of these being renal cell carcinomas. Lower rates of renal cell carcinoma are reported for Africa and these are expected to change for a
Anderson Mutuiri, Samuel Gakinya
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Renal cell carcinoma with melanin pigment

Indian Journal of Urology, 2010
The incidence of renal cell carcinoma has been steadily increasing. There are several morphological types of renal cell carcinoma. Recognizing histologic patterns of renal cell carcinoma is important for correct diagnosis and subsequent medical care for ...
Jayaprakash Shetty, Chandrika, Prabhu Laxman   +2 more
doaj   +1 more source

Lower circulating adiponectin is associated with higher risk of renal cell carcinoma: A meta-analysis

The International Journal of Biological Markers, 2020
Background: Changes in circulating adiponectin have been related to the risks of various cancers. However, the association between circulating adiponectin and the risk of renal cell carcinoma has not been fully determined.
Jiajie Fang, Xuanli Xu, Qiqi Mao, Yufan Ying, Xu Zhang, Liping Xie   +5 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

MiR-122 promotes renal cancer cell proliferation by targeting Sprouty2

Tumor Biology, 2017
MicroRNAs are short non-coding RNAs, which have been implicated in several biological processes. Aberrant expression of the microRNA miR-122 has frequently been reported in malignant cancers.
Zijie Wang, Chao Qin, Jing Zhang, Zhijian Han, Jun Tao, Qiang Cao, Wanli Zhou, Zhen Xu, Chunchun Zhao, Ruoyun Tan, Min Gu   +10 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source