Results 1 to 10 of about 3,494 (200)

Cardenolide-Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non-small Cell Lung Cancer Cells. [PDF]

Small Methods
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Dorfner M, Mifka A, de Pádua RM, da Silva IT, Guterres IZ, Sana L, Fuhrmann G, Munkert J.   +7 more
europepmc   +2 more sources

Secondary Compounds in Milkweed Nectar Negatively Impact Thermal Tolerance in Bumble Bees. [PDF]

Ecol Evol
This study shows that exposure to cardenolide toxins in floral nectar impacts heat tolerance in bumble bees at field‐realistic doses. Various honeys, aside from milkweed honey, did not impact heat tolerance in these bees. These data suggest that compounds in their diet may impact resilience of bees to global warming and that milkweed‐specialists may be
Shippee R, Feuerborn C, Bradley A, Jahnke H, Hines HM.   +4 more
europepmc   +2 more sources

Aphid Resistance Segregates Independently of Cardenolide and Glucosinolate Content in an Erysimum cheiranthoides (Wormseed Wallflower) F2 Population [PDF]

Plants
Plants in the genus Erysimum produce both glucosinolates and cardenolides as a defense mechanism against herbivory. Two natural isolates of Erysimum cheiranthoides (wormseed wallflower) differed in their glucosinolate content, cardenolide content, and ...
Mahdieh Mirzaei, Gordon C. Younkin, Adrian F. Powell, Martin L. Alani, Susan R. Strickler, Georg Jander   +5 more
doaj   +2 more sources

New Structures, Spectrometric Quantification, and Inhibitory Properties of Cardenolides from Asclepias curassavica Seeds [PDF]

Molecules, 2022
Cardiac glycosides are a large class of secondary metabolites found in plants. In the genus Asclepias, cardenolides in milkweed plants have an established role in plant–herbivore and predator–prey interactions, based on their ability to inhibit the ...
Paola Rubiano-Buitrago, Shrikant Pradhan, Christian Paetz, Hannah M. Rowland   +3 more
doaj   +2 more sources

Chemoenzymatic synthesis of the cardenolide rhodexin A and its aglycone sarmentogenin [PDF]

Beilstein Journal of Organic Chemistry
Herein, we report a concise chemoenzymatic synthesis of the cardenolide rhodexin A in 9 steps and the first protecting-group-free synthesis of its aglycone sarmentogenin in 7 steps from 17-deoxycortisone. The synthesis features a scalable enzymatic C14–H
Fuzhen Song, Mengmeng Zheng, Dongkai Wang, Xudong Qu, Qianghui Zhou   +4 more
doaj   +2 more sources

Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]

Chemistry
We describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N, Eid S, Schmitt-Ulms G, Nagorny P.   +3 more
europepmc   +2 more sources

Thevetia thevetioides Cardenolide and Related Cardiac Glycoside Profile in Mature and Immature Seeds by High-Resolution Thin-Layer Chromatography (HPTLC) and Quadrupole Time of Flight–Tandem Mass Spectrometry (Q-TOF MS/MS) Reveals Insights of the Cardenolide Biosynthetic Pathway [PDF]

Molecules
Thevetia thevetioides is a species within the Apocynaceae family known for containing cardenolide-glycosides, commonly referred to as cardiac glycosides, which are characteristic of this genus.
Juan Vázquez-Martínez, Paulina Bravo-Villa, Jorge Molina-Torres   +2 more
doaj   +2 more sources

Functional Profiles of Phyllosphere and Rhizosphere Metagenomes Differ Across Milkweed Species [PDF]

Environ Microbiol Rep
We characterised milkweed microbiomes using a metagenomics approach to investigate the functional potential of endophytic phyllosphere and rhizosphere communities. We found evidence that the composition of potential PSM genes varied across milkweeds in spp. specific responses, for both phyllospheres and rhizospheres, and in response to monarch feeding.
Hansen T, Enders L.
europepmc   +2 more sources

Progestogens and androgens influence root morphology of angiosperms in a brassinosteroid-independent manner. [PDF]

Plant J
Significance Statement Plants produce progesterone and androgens, which alter root morphology in A. thaliana and 60% of tested angiosperms. Brassinosteroids seem uninvolved. Understanding the mechanism is like navigating an unknown city—exemplarily Dittelbrunn (a small village in Bavaria)—where the expected shortcut (interaction with brassinosteroids ...
Körber KL, Paul S, Oklestkova J, Barth E, Feistel F, Oppermann H, Oktay C, Dorfner M, Strnad M, Munkert J, Furch ACU, Klein J.   +11 more
europepmc   +2 more sources

Substrate Specificity of ABCB Transporters Predicted by Docking Simulations Can Be Confirmed by Experimental Tests [PDF]

Molecules
ATP-binding cassette (ABC) transporters, particularly those of subfamily B, are involved in cell detoxification, multidrug resistance, drug treatment pharmacodynamics, and also ecological adaptation.
Mario Röpcke, Sha Lu, Cäcilia Plate, Fee Meinzer, Antonia Lisiecki, Susanne Dobler   +5 more
doaj   +2 more sources