Total Synthesis of Cardenolides Acospectoside A and Acovenoside B [PDF]
MoleculesAcospectoside A (1) and acovenoside B (2), two cytotoxic cardenolides extracted from the venomous South African bush Acokanthera oppositifolia, are distinguished by their unique structural motifs of the l-acovenose moiety at C-3 and a 1β-O-acetylated ...
Benzhang Liu, Peng Xu, Biao Yu
doaj +2 more sources
Identification of UDP-dependent glycosyltransferases in the wallflower cardenolide biosynthesis pathway. [PDF]
J Biol ChemPatrick OS +5 more
europepmc +2 more sources
Secondary Compounds in Milkweed Nectar Negatively Impact Thermal Tolerance in Bumble Bees. [PDF]
Ecol EvolThis study shows that exposure to cardenolide toxins in floral nectar impacts heat tolerance in bumble bees at field‐realistic doses. Various honeys, aside from milkweed honey, did not impact heat tolerance in these bees. These data suggest that compounds in their diet may impact resilience of bees to global warming and that milkweed‐specialists may be
Shippee R +4 more
europepmc +2 more sources
Nectar cardenolides and floral volatiles mediate a specialized wasp pollination system. [PDF]
J Exp BiolBurger H +5 more
europepmc +2 more sources
Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]
ChemistryWe describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N +3 more
europepmc +2 more sources
Addressing the Evolution of Cardenolide Formation in Iridoid-Synthesizing Plants: Site-Directed Mutagenesis of PRISEs (Progesterone-5β-Reductase/Iridoid Synthase-like Enzymes) of Plantago Species. [PDF]
MoleculesDorfner M +5 more
europepmc +3 more sources
Frontiers in Pharmacology, 2021 Cardenolide glycosides are natural compounds known to inhibit the ion pumping function of the Na+/K+-ATPase in cellular systems. Interestingly, various cancer cell types are highly susceptible to cardenolide glycosides. Herein, we explore the cardenolide
Susanne Hafner +2 more
doaj +1 more source
Gut-specific cardenolide-resistant sodium pump primed an omnivore to feed on toxic oleander
iScience, 2022 Summary: Apocynaceae plants produce toxic cardenolides to defend against their herbivores. Cardenolides could inhibit the α subunit of Na+⁄K+-ATPase (ATPα), which plays critical roles in biological processes such as muscle contraction, neural function ...
Tianyu Wang, Lina Shi, Ying Zhen
doaj +1 more source
Characterization and Chromatographic Fingerprint Analysis of Traditional Wallflower Oil [PDF]
Research Journal of Pharmacognosy, 2021 Background and objective: Wallflower oil is made from the flowers of Erysimum cheiri (L.) Crantz which is a herb rich in cardenolide compounds. Wallflower oil was traditionally indicated for analgesic, anti-inflammatory, hair tonic, and wound healing ...
Ghazaleh Mosleh +2 more
doaj +1 more source
Progestogens and androgens influence root morphology of angiosperms in a brassinosteroid-independent manner. [PDF]
Plant JSignificance Statement Plants produce progesterone and androgens, which alter root morphology in A. thaliana and 60% of tested angiosperms. Brassinosteroids seem uninvolved. Understanding the mechanism is like navigating an unknown city—exemplarily Dittelbrunn (a small village in Bavaria)—where the expected shortcut (interaction with brassinosteroids ...
Körber KL +11 more
europepmc +2 more sources