Results 71 to 80 of about 2,370 (198)

Optimizing Growth Conditions for Digoxin Production in Digitalis lanata Ehrh

World Journal of Traditional Chinese Medicine, 2016
Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extracted from cultivated Digitalis lanata
Herman A. van Wietmarschen, Hansjörg Hagels, Ron Peters, Jolanda Heistek, Jan van der Greef, Mei Wang   +5 more
doaj   +1 more source

Identification of anti-viral activity of the cardenolides, Na+/K+-ATPase inhibitors, against porcine transmissible gastroenteritis virus

, 2017
[[abstract]]A series of naturally occurring cardenolides that exhibit potent anti-transmissible gastroenteritis virus (TGEV) activity in swine testicular (ST) cells has been identified.
Yang, CW;Chang, HY;Hsu, HY;Lee, YZ;Chang, HS;Chen, IS;Lee, SJ
core   +1 more source

Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae

MicrobiologyOpen, 2019
A yeast expression plasmid was constructed containing a cardenolide biosynthetic module, referred to as CARD II, using the AssemblX toolkit, which enables the assembly of large DNA constructs.
Christoph Rieck, Daniel Geiger, Jennifer Munkert, Katrin Messerschmidt, Jan Petersen, Juliane Strasser, Nadine Meitinger, Wolfgang Kreis   +7 more
doaj   +1 more source

Cardenolides isolated from Gomphocarpus sinaicus and Pergularia tomentosa (Asclepiadaceae) deter the feeding of a generalist caterpillar, Spodoptera littoralis

, 2011
Methanol extracts of Gomphocarpus sinaicus, Pergularia tomentosa and Cynanchum acutum (Apocynaceae, sub-family Asclepiadoideae) deterred feeding of Spodoptera littoralis in a binary-choice bioassay.
Philip C. Stevenson, Green, Paul W.C., Veitch, Nigel C., Nigel C. Veitch, Monique S. J. Simmonds, Simmonds, Monique S.J., Stevenson, Philip C., Paul W. C. Green   +7 more
core   +1 more source

Allamanda cathartica leaves do not contain cardioactive glycosides [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Allamanda cathartica, a plant used in traditional medicine for different purposes, has been considered a cardiotoxic plant. However, the alleged cardiac glycoside was not further studied. Thus, the present study aimed to determine whether the leaves of A.
B.P. Santos, G.P.P. Ataíde, C.J.C. Saraiva, M.S. Teixeira, B. Soto-Blanco   +4 more
doaj   +1 more source

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

PLoS ONE, 2018
Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in ...
Martin Liss, Michael H Radke, Jamina Eckhard, Martin Neuenschwander, Vita Dauksaite, Jens-Peter von Kries, Michael Gotthardt   +6 more
doaj   +1 more source

Cardenolides are potent inhibitors of RBM20 dependent titin splicing.

, 2018
Figure layout and panels as described in Fig 3. (a, b) Additional cardenolides not present in the original library were selected to evaluate their potency to inhibit RBM20 dependent titin splicing.
Jens-Peter von Kries (5368169), Martin Liss (5368172), Michael H. Radke (5368175), Martin Neuenschwander (680771), Michael Gotthardt (755019), Jamina Eckhard (370592), Vita Dauksaite (5368178)   +6 more
core   +1 more source

Arbuscular mycorrhizal fungi alter above- and below-ground chemical defense expression differentially among Asclepias species

Frontiers in Plant Science, 2013
Belowground symbionts of plants can have substantial influence on plant growth and nutrition. Recent work demonstrates that mycorrhizal fungi can affect plant resistance to herbivory and the performance of above and belowground herbivores. Although these
Rachel L Vannette, Rachel L Vannette, Mark D. Hunter, Sergio eRasmann   +3 more
doaj   +1 more source

Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives

World Journal of Traditional Chinese Medicine, 2015
Toad venom, called as ChanSu in China, is a widely used traditional Chinese medicine (TCM) whose active components are mainly bufadienolides. ChanSu could exhibit cardiotonic, anti-microbial, anti-inflammatory and, most importantly, anti-cancer effects ...
Miao Liu, Li-Xing Feng, Li-Hong Hu, Xuan Liu, De-An Guo   +4 more
doaj   +1 more source

19-Nor- and 18,20-Epoxy-cardenolides from the Leaves of Calotropis gigantea

, 2016
Two new cardenolides (1 and 2) along with 12 known compounds were isolated from the dichloromethane extract of the leaves of Calotropis gigantea. The structural elucidation was accomplished by spectroscopic methods.
Somyote Sutthivaiyakit (2188786), Thitima Lhinhatrakool (2188789)   +1 more
core   +1 more source