Results 21 to 30 of about 511,264 (218)

The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction. [PDF]

PLoS ONE, 2017
Cardiac glycosides such as digoxin are Na+/K+-ATPase inhibitors that are widely used for the treatment of chronic heart failure and cardiac arrhythmias; however, recent epidemiological studies have suggested a relationship between digoxin treatment and ...
Motoi Kobayashi, Fumitake Usui-Kawanishi, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Nathan Mise, Fujio Kayama, Tadashi Kasahara, Naoyuki Hasebe, Masafumi Takahashi   +9 more
doaj   +1 more source

Obeticholic acid treatment ameliorates the cardiac dysfunction in NASH mice.

PLoS ONE, 2022
BackgroundSuppression of cardiac iinflammasome, which can be inhibited by Farnesoid X receptor (FXR) agonist, can ameliorate cardiac inflammation and fibrosis.
Szu-Yu Liu, Chia-Chang Huang, Ying-Ying Yang, Shiang-Fen Huang, Tzung-Yan Lee, Tzu-Hao Li, Ming-Chih Hou, Han-Chieh Lin   +7 more
doaj   +3 more sources

Machine learning for spatial stratification of progressive cardiovascular dysfunction in a murine model of type 2 diabetes mellitus.

PLoS ONE, 2023
Speckle tracking echocardiography (STE) has been utilized to evaluate independent spatial alterations in the diabetic heart, but the progressive manifestation of regional and segmental cardiac dysfunction in the type 2 diabetic (T2DM) heart remains ...
Andrya J Durr, Anna S Korol, Quincy A Hathaway, Amina Kunovac, Andrew D Taylor, Saira Rizwan, Mark V Pinti, John M Hollander   +7 more
doaj   +1 more source

Right ventricular diastolic function in post-surgical Tetralogy of Fallot patients: A pilot study to make a comparison between echocardiography and cardiac MRI

International Journal of Cardiology Congenital Heart Disease, 2021
Background: right ventricular (RV) systolic dysfunction is associated with poor outcomes in Tetralogy of Fallot (ToF) patients. Conversely, the influence of diastolic dysfunction in this setting is poorly known.
Pier Paolo Bassareo, Martino Deidda, Giuseppe Calcaterra, Andrea Raffaele Marras, Mariangela Marras, Luca Saba   +5 more
doaj   +1 more source

SIRT1 Activation Attenuates the Cardiac Dysfunction Induced by Endothelial Cell-Specific Deletion of CRIF1

Biomedicines, 2021
The CR6-interacting factor1 (CRIF1) mitochondrial protein is indispensable for peptide synthesis and oxidative phosphorylation. Cardiomyocyte-specific deletion of CRIF1 showed impaired mitochondrial function and cardiomyopathy.
Shuyu Piao, Ikjun Lee, Seon-Ah Jin, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Byeong Hwa Jeon, Cuk-Seong Kim   +7 more
doaj   +1 more source

Echocardiographic Assessment of Cardiac Function in Liver Cirrhosis: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Echocardiography is a noninvasive method to assess the cardiac dysfunction in liver cirrhosis. Early detection of cardiac dysfunction helps prevent morbidity in patients undergoing haemodynamics altering procedures like liver transplant
Apoorva Nirmal, Gajendra Agrawal, Sunil Kumar, Sourya Acharya, Akshay Dafal, Dwivedi Bhushan   +5 more
doaj   +1 more source

Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression

Biology Direct, 2023
Background Long-term consumption of an excessive fat and sucrose diet (Western diet, WD) has been considered a risk factor for metabolic syndrome (MS) and cardiovascular disease.
I.-Fan Liu, Tzu-Chieh Lin, Shu-Chi Wang, Chia-Hung Yen, Chia-Yang Li, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yuan Chang, Chuang-Rung Chang, Yung-Hsiang Chen, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chih-Hsin Hsu, Shing-Jong Lin, Po-Len Liu   +15 more
doaj   +1 more source

Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction

Frontiers in Endocrinology, 2023
ObjectiveSepsis is a life-threatening condition secondary to infection that evolves into a dysregulated host response and is associated with acute organ dysfunction.
Yan Cao, Yan Cao, Zhengyu Liu, Zhengyu Liu, Wenfeng Ma, Chen Fang, Yanfang Pei, Yingxia Jing, Jie Huang, Xiaotong Han, Xiaotong Han, Weiwei Xiao   +11 more
doaj   +1 more source

IL-12p40 deletion aggravates lipopolysaccharide-induced cardiac dysfunction in mice

Frontiers in Cardiovascular Medicine, 2022
BackgroundCardiac dysfunction is one of the most common complications of sepsis and is associated with the adverse outcomes and high mortality of sepsis patients. IL-12p40, the common subunit of IL-12 and IL-23, has been shown to be involved in a variety
Menglin Liu, Zhen Wang, Jishou Zhang, Di Ye, Menglong Wang, Yao Xu, Mengmeng Zhao, Yongqi Feng, Xiyi Lu, Heng Pan, Wei Pan, Cheng Wei, Dan Tian, Wenqiang Li, Jingjun Lyu, Jing Ye, Jun Wan   +16 more
doaj   +1 more source

Risk factors for transient dysfunction of gas exchange after cardiac surgery

Brazilian Journal of Cardiovascular Surgery, 2015
Objective: A retrospective cohort study was preformed aiming to verify the presence of transient dysfunction of gas exchange in the postoperative period of cardiac surgery and determine if this disorder is linked to cardiorespiratory events.
Cristiane Delgado Alves Rodrigues, Marcos Mello Moreira, Núbia Maria Freire Vieira Lima, Luciana Castilho de Figueirêdo, Antônio Luis Eiras Falcão, Orlando Petrucci Junior, Desanka Dragosavac   +6 more
doaj   +1 more source