Results 101 to 110 of about 862,015 (296)

Cardiac Fibrosis: Only from Resident Cardiac Fibroblasts?

Central Asian Journal of Medical Sciences, 2019
No abstract in ...
Pagmadulam Sukhbaatar, Chingerel Khorloo, Bat-Erdene Nyamsuren, Byambasuren Vanchin   +3 more
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Fibroblast Reprogramming in Cardiac Repair

JACC: Basic to Translational Science
Cardiovascular disease is one of the major causes of death worldwide. Limited proliferative capacity of adult mammalian cardiomyocytes has prompted researchers to exploit regenerative therapy after myocardial injury, such as myocardial infarction, to attenuate heart dysfunction caused by such injury.
Wang, Qiaozi, Spurlock, Brian, Liu, Jiandong, Qian, Li   +3 more
openaire   +2 more sources

ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction

Journal of Advanced Research
Introduction: N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an m6A “eraser”, is responsible for decreased m6A modification.
Kun Yang, Yongchao Zhao, Jingjing Hu, Rifeng Gao, Jiaran Shi, Xiang Wei, Juntao Chen, Kai Hu, Aijun Sun, Junbo Ge   +9 more
doaj   +1 more source

Fibroblast Growth Factor 22 is not essential for skin development and repair but plays a role in tumorigenesis [PDF]

, 2012
Fibroblast Growth Factors play critical roles during development, tissue homeostasis and repair by controlling cell proliferation, survival, migration and differentiation.
Robbez-Masson, L, Ian Rosewell, Grose Richard, Cross, B, Rosewell, I, Athina-Myrto Chioni (156542), Robbez-Masson, Luisa, Rosewell Ian, Chioni Athina-Myrto, Jarosz, Monika, Barbara Cross (156544), Barbara Cross, Grose, Richard, Chioni, A-M, Rosewell, Ian, Cross Barbara, Richard Grose (156552), Chioni, Athina-Myrto, Cross, Barbara, Jarosz, M, Luisa Robbez-Masson (156539), Grose, R, Luisa Robbez-Masson, Jarosz Monika, Ian Rosewell (156548), Monika Jarosz, Richard Grose, Robbez-Masson Luisa, Monika Jarosz (156537), Athina-Myrto Chioni   +29 more
core   +2 more sources

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Oxidative modification of miR-30c promotes cardiac fibroblast proliferation via CDKN2C mismatch

Scientific Reports
The response of cardiac fibroblast proliferation to detrimental stimuli is one of the main pathological factors causing heart remodeling. Reactive oxygen species (ROS) mediate the proliferation of cardiac fibroblasts.
Wenguang Chang, Dandan Xiao, Xinyu Fang, Jianxun Wang   +3 more
doaj   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Primary, cardiac, fibroblastic osteosarcoma

Medicine, 2018
Primary cardiac osteosarcoma is a rare tumor. To our knowledge, only 15 cases have been reported in the literature in the past 10 years. We describe a case of primary, cardiac, fibroblastic osteosarcoma in a 42-year-old woman.A 42-year-old woman with a 10-day history of chest pain.
Li, Yangyang, Ye, Teng, Gu, Qianru, Dong, Lei, Chen, Guorong, Lu, Shanshan   +5 more
openaire   +2 more sources

MicroRNA-1-Mediated Inhibition of Cardiac Fibroblast Proliferation Through Targeting Cyclin D2 and CDK6

Frontiers in Cardiovascular Medicine, 2019
MicroRNA-1 (miRNA-1) has been long viewed as a muscle-specific miRNA and plays a critical role in myocardium and cardiomyocytes by controlling myocyte growth and rhythm. We identified that miRNA-1 is expressed in cardiac fibroblasts, which are one of the
Nedyalka Valkov, Nedyalka Valkov, Michelle E. King, Jacob Moeller, Hong Liu, Xiaofei Li, Peng Zhang   +6 more
doaj   +1 more source