Results 131 to 140 of about 862,015 (296)

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Suppression of CSF2RA macrophage polarisation impacts pathological cardiac remodelling in mice

Scientific Reports
Granulocyte-macrophage colony-stimulating factor (GM-CSF; CSF2) has emerged as an important regulator of pro-inflammatory macrophage polarisation, with pro-inflammatory responses recognised to influence cardiac remodelling and repair after cardiac injury.
Georgios Kremastiotis, Yong Li, Andrew Bond, Daire Shanahan, Karina Di Gregoli, Alastair W. Poole, Sarah J. George, Jason L. Johnson   +7 more
doaj   +1 more source

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source

Cardiac Fibroblast Heterogeneity and Epigenomic Regulation in Heart Failure

Cardiac fibrosis is a key pathological feature of heart disease that contributes to stiffening of the heart and worsens clinical outcomes, yet it remains untargeted by current therapies.
Gehred, Natalie
core   +1 more source

VAP1 promotes cardiac fibrosis by enabling PDGFR signaling in myofibroblasts

Experimental and Molecular Medicine
Excessive fibrogenesis is associated with adverse cardiac remodeling and heart failure. Myofibroblast, primarily derived resident fibroblast, is the effector cell type in cardiac fibrosis.
Shan Huang, Qianwen Zhao, Tinghui Shao, Chenghao Zhu, Yujia Xue, Naxia Chen, Yue Zhang, Huihui Xu, Ming Kong, Rui Wang   +9 more
doaj   +1 more source

Defining murine cardiac fibroblast cellular states via fibroblast-vascular crosstalk and extracellular matrix remodeling

, 2022
Thesis (Ph.D.)--University of Washington, 2022The overarching focus of this thesis is to gain insight into novel categories of cardiac fibroblast cellular state by probing the biological underpinnings of how structure dictates function.
Olszewski, Emily
core  

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Role of autophagy in cardiac fibroblast activation in cardiac fibrosis

, 2016
Following myocardial infarction (MI), initial cardiac remodeling or wound repair/healing is beneficial and required for continued function. During the wound healing phase, cardiac fibroblasts activate to become contractile and hypersynthetic ...
Gupta, Shivika
core  

Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation

, 2005
International audienceAbstract The process of cardiac hypertrophy is considered to involve two components: that of cardiac myocyte (CM) enlargement and cardiac fibroblast (CF) proliferation.
Adriana Delwail, Fredj, Sandra, Jean-claude Lecron, Bescond, Jocelyn, Louault, Claire, Sandra Fredj, Delwail, Adriana, Potreau, Daniel, Daniel Potreau, Claire Louault, Lecron, Jean‐claude, Jocelyn Bescond   +11 more
core   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source