Results 31 to 40 of about 145,404 (307)
A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]
, 2017 Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco +15 more
core +3 more sources
Exploring the cardiac ECM during fibrosis: A new era with next-gen proteomics
Frontiers in Molecular Biosciences, 2022 Extracellular matrix (ECM) plays a critical role in maintaining elasticity in cardiac tissues. Elasticity is required in the heart for properly pumping blood to the whole body. Dysregulated ECM remodeling causes fibrosis in the cardiac tissues.
Vivek Sarohi +5 more
doaj +1 more source
Defining the Cardiac Fibroblast
Circulation Journal, 2016 Cardiac fibrosis remains an important health concern, but the study of fibroblast biology has been hindered by a lack of effective means for identifying and tracking fibroblasts. Recent advances in fibroblast-specific lineage tags and reporters have permitted a better understanding of these cells.
Malina J, Ivey, Michelle D, Tallquist
openaire +3 more sources
The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
core +4 more sources
Consequences of PDGFRα+ fibroblast reduction in adult murine hearts
eLife, 2022 Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many cardiac pathologies and is generally deleterious, the role of fibroblasts in maintaining the ...
Jill T Kuwabara +14 more
doaj +1 more source
Cells, 2022 Cardiac fibroblasts regulate the development of the adult cardiomyocyte phenotype and cardiac remodeling in disease. We investigate the role that cardiac fibroblasts-secreted extracellular vesicles (EVs) have in the modulation of cardiomyocyte Ca2 ...
Brian X. Wang +6 more
doaj +1 more source
Cardiac Fibrosis: Only from Resident Cardiac Fibroblasts?
Central Asian Journal of Medical Sciences, 2019 No abstract in ...
Pagmadulam Sukhbaatar +3 more
openaire +2 more sources
Heartbreak hotel: a convergence in cardiac regeneration [PDF]
, 2016 In February 2016, the Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on ‘Transdifferentiation and Tissue Plasticity in Cardiovascular
Schneider, MD
core +1 more source
Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. [PDF]
, 2015 The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor ...
Kim, Hyun Jin +5 more
core +3 more sources
Fibroblast contributions to ischemic cardiac remodeling
Cellular Signalling, 2021 The heart can respond to increased pathophysiological demand through alterations in tissue structure and function . This process, called cardiac remodeling, is particularly evident following myocardial infarction (MI), where the blockage of a coronary artery leads to widespread death of cardiac muscle.
Ryan M, Burke +2 more
openaire +3 more sources