Results 71 to 80 of about 862,015 (296)

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Integrins, Focal Adhesions, and Cardiac Fibroblasts [PDF]

Journal of Investigative Medicine, 2009
How the myocardium undergoes geometric, structural, and molecular alterations that result in an end phenotype as might be seen in patients with dilated cardiomyopathy or after myocardial infarction is still poorly understood. Structural modification of the left ventricle, which occurs during these pathological states, results from long-term changes in ...
Ana Maria, Manso, Seok-Min, Kang, Robert S, Ross   +2 more
openaire   +2 more sources

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

Frontiers in Pharmacology, 2017
Background and Purpose: Cardiac fibrosis is characterized by an increase in fibroblast proliferation, overproduction of extracellular matrix proteins, and the formation of myofibroblast that express α-smooth muscle actin (α-SMA).
Sarawuth Phosri, Ajaree Arieyawong, Kwanchai Bunrukchai, Warisara Parichatikanond, Akiyuki Nishimura, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida, Supachoke Mangmool   +8 more
doaj   +1 more source

Emerging role of transient receptor potential (TRP) ion channels in cardiac fibroblast pathophysiology

Frontiers in Physiology, 2022
Cardiac fibroblasts make up a major proportion of non-excitable cells in the heart and contribute to the cardiac structural integrity and maintenance of the extracellular matrix.
Asfree Gwanyanya, Kanigula Mubagwa, Kanigula Mubagwa   +2 more
doaj   +1 more source

SalA inhibited cardiac fibroblast migration induced by MMP-9 CD.

, 2013
(A) The representative pictures for migration of cardiac fibroblast detected by transwell migration assay, the magnification was 200 X. (B) The quantitative data for migration of cardiac fibroblast. (C) Proliferation of cardiac fibroblast detected by CCK-
Defang Li (207378), Hualiang Jiang (19452), Fukang Teng (207390), Xu Shen (66684), De-an Guo (2126713), Wanying Wu (207392), Song Xue (316115), Cheng Luo (48047), Wengang Yang (337270), Feng Xu (89016), Jun Yin (94374), Yanhui Wang (108090), Baohong Jiang (207398), Xiangqian Kong (166573), Xuan Liu (49954), Hui Chen (28597), Yanping Deng (207361), Jing Chen (4762)   +17 more
core   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Rationale for mapping the cardiac fibroblast.

, 2015
(A) Relationship between cardiac fibroblast and other cell types. (B) Yearly publication in PubMed database related to the cardiac fibroblast. Both cardiac fibroblasts and fibroblasts from other sources (such as that from the tail) have been recently ...
Hiroaki Kitano (5834), Milena B. Furtado (205827), Hieu T. Nim (837813), Mauro W. Costa (205822), Nadia A. Rosenthal (165755), Sarah E. Boyd (174231)   +5 more
core   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Origin of Cardiac Fibroblasts and the Role of Periostin [PDF]

Circulation Research, 2009
Abstract: Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the ventricles.
Paige, Snider, Kara N, Standley, Jian, Wang, Mohamad, Azhar, Thomas, Doetschman, Simon J, Conway   +5 more
openaire   +2 more sources

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source