Results 41 to 50 of about 182,384 (307)

Single-cell analysis reveals lysyl oxidase (Lox)+ fibroblast subset involved in cardiac fibrosis of diabetic mice

Journal of Advanced Research, 2023
Introduction: Myocardial fibrosis and cardiac dysfunction are the main characteristics of diabetic heart disease. However, the molecular mechanisms underlying diabetic myocardial fibrosis remain unclear.
Heyangzi Li, Xiaoqing Zhu, Xi Cao, Yicheng Lu, Jianwei Zhou, Xiaoming Zhang   +5 more
doaj   +1 more source

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]

, 2017
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco, Bordin, Antonella, Carrizzo, Albino, Chimenti, Isotta, DE FALCO, Elena, Forte, Maurizio, Frati, Giacomo, Nocella, Cristina, Pagano, Francesca, Palmerio, Silvia, Schiavon, Sonia, Schirone, Leonardo, Sciarretta, Sebastiano, Valenti, Valentina, Vecchione, Carmine, Yee, Derek   +15 more
core   +3 more sources

Fibroblast contributions to ischemic cardiac remodeling

Cellular Signalling, 2021
The heart can respond to increased pathophysiological demand through alterations in tissue structure and function . This process, called cardiac remodeling, is particularly evident following myocardial infarction (MI), where the blockage of a coronary artery leads to widespread death of cardiac muscle.
Ryan M, Burke, Kimberly N, Burgos Villar, Eric M, Small   +2 more
openaire   +3 more sources

Inflammatory activation of human cardiac fibroblasts leads to altered calcium signaling, decreased connexin 43 expression and increased glutamate secretion

Heliyon, 2017
Cardiac fibroblasts, which are abundant in heart tissue, are involved not only in extracellular matrix homeostasis and repair, but also in cardiac remodeling after a myocardial infarction that, in turn, can lead to loss of cardiac function and heart ...
Eva Skiöldebrand, Annika Lundqvist, Ulrika Björklund, Mikael Sandstedt, Anders Lindahl, Elisabeth Hansson, Lillemor Mattsson Hultén   +6 more
doaj   +1 more source

Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators

Acta Pharmaceutica Sinica B, 2020
Overexpression of exogenous lineage-determining factors succeeds in directly reprogramming fibroblasts to various cell types. Several studies have reported reprogramming of fibroblasts into induced cardiac progenitor cells (iCPCs).
Jianglin Wang, Xueyan Jiang, Lixin Zhao, Shengjia Zuo, Xiantong Chen, Lingmin Zhang, Zhongxiao Lin, Xiaoya Zhao, Yuyan Qin, Xinke Zhou, Xi-Yong Yu   +10 more
doaj   +1 more source

3D Cell Migration Studies for Chemotaxis on Microfluidic-Based Chips: A Comparison between Cardiac and Dermal Fibroblasts

Bioengineering, 2018
Fibroblast migration to damaged zones in different tissues is crucial to regenerate and recuperate their functional activity. However, fibroblast migration patterns have hardly been studied in disease terms.
Sandra Pérez-Rodríguez, Esther Tomás-González, José Manuel García-Aznar   +2 more
doaj   +1 more source

Fibroblast transition to an endothelial “trans” state improves cell reprogramming efficiency

Scientific Reports, 2021
Fibroblast reprogramming offers the potential for myocardial regeneration via in situ cell transdifferentiation. We explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency.
Megumi Mathison, Deepthi Sanagasetti, Vivek P. Singh, Aarthi Pugazenthi, Jaya Pratap Pinnamaneni, Christopher T. Ryan, Jianchang Yang, Todd K. Rosengart   +7 more
doaj   +1 more source

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes, Csilla Nemes, Eszter Varga, Jalving M., Melinda K. Pirity, Nuttha Klincumhom, Zsuzsanna Polgar   +6 more
core   +1 more source

Cardiac fibroblasts regulate sympathetic nerve sprouting and neurocardiac synapse stability.

PLoS ONE, 2013
Sympathetic nervous system (SNS) plays a key role in cardiac homeostasis and its deregulations always associate with bad clinical outcomes. To date, little is known about molecular mechanisms regulating cardiac sympathetic innervation.
Céline Mias, Christelle Coatrieux, Colette Denis, Gaël Genet, Marie-Hélène Seguelas, Nathalie Laplace, Charlotte Rouzaud-Laborde, Denis Calise, Angelo Parini, Daniel Cussac, Atul Pathak, Jean-Michel Sénard, Céline Galés   +12 more
doaj   +1 more source

Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a β-Adrenoreceptor-Dependent Mechanism

Cells, 2020
Cardiac fibrosis represents a serious clinical problem. Development of novel treatment strategies is currently restricted by the lack of the relevant experimental models in a human genetic context.
Przemysław Błyszczuk, Christian Zuppinger, Ana Costa, Daria Nurzynska, Franca Di Meglio, Mara Stellato, Irina Agarkova, Godfrey L. Smith, Oliver Distler, Gabriela Kania   +9 more
doaj   +1 more source