Results 91 to 100 of about 31,824 (209)

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta [PDF]

, 2013
Despite numerous examples of the effects of the human gastrointestinal microbiome on drug efficacy and toxicity, there is often an incomplete understanding of the underlying mechanisms. Here, we dissect the inactivation of the cardiac drug digoxin by the
Balskus, Emily Patricia, Chatman, Kelly, Gootenberg, David Benjamin, Haiser, Henry J., Sirasani, Gopal, Turnbaugh, Peter   +5 more
core   +1 more source

Topics on the Na+/Ca2+ Exchanger: Role of Vascular NCX1 in Salt-Dependent Hypertension

Journal of Pharmacological Sciences, 2006
Excess salt intake is a major risk factor for hypertension. However, the molecular mechanisms underlying salt-dependent hypertension remain obscure. Our recent studies using selective Na+/Ca2+ exchange inhibitors and genetically engineered mice provide ...
Takahiro Iwamoto, Satomi Kita
doaj   +1 more source

Mechanisms contributing to the cardiac inotropic effect of Na pump inhibition and reduction of extracellular Na. [PDF]

, 1987
Reduction of the transsarcolemmal [Na] gradient in rabbit cardiac muscle leads to an increase in the force of contraction. This has frequently been attributed to alteration of Ca movements via the sarcolemmal Na/Ca exchange system.
Bers, DM
core  

Severe symptomatic bradycardia after a dinner of spicy oleander soup

Emergency Care Journal, 2016
Cardiac glycosides similar to digoxin are produced by different plants in nature. Nerium oleander, commonly grown as an ornamental shrub, can be found worldwide in temperate countries. Intentional or accidental ingestion of any part of the plant can lead
Andrea Tampieri, Fabrizio Mucci, Valeria Palmonari, Eugenio Giovannini, Tiziano Lenzi, Patrizia Cenni   +5 more
doaj   +1 more source

Anatomical and Phytochemical Studies of the Leaves and Roots of Urginea grandiflora Bak. and Pancratium tortuosum Herbert [PDF]

, 2010
Urginea grandiflora Bak. and Pancratium tortuosum Herbert are bulbous, medicinal plants endemic to the Sudan. The aim of this study was to provide information on the anatomical properties of the leaves and roots of these two bulbous plants.
Elreish, B. I. Abu, Sultan, H. A. S., Yagi, S. M.   +2 more
core   +1 more source

Phytochemical Screening of Wellawel (Chromolaena odorata) leaves, its Antimicrobial and Coagulative Properties

JPAIR, 2008
The study was conducted to perform phytochemical screening, antimicrobial assay and determine the coagulating effects of wellawel (Chromolaena odorata) leaves. This study made use of the experimental research design in an actual laboratory set-up.  There
Larguita P. Reotutar, Gemma Agnes R. Supnet   +1 more
doaj   +1 more source

ACUTE INTAKE OF A LARGE DOSE OF CARDIAC GLYCOSIDES BY A YOUNG MALE

Проблеми екології та медицини, 2017
One of the most toxic drugs is a group of cardiac glycosides. Having a very narrow spectrum of therapeutic action, cardiac glycosides are able to cause serious intoxication with complications including arrhythmias and conduction disorder, which often ...
L. Savchenko, I. Mormol, P. Husar, N. Reva, O. Borzykh, I. Kaydashev   +5 more
doaj  

Antidote use for cardiac arrest or hemodynamic instability due to cardiac glycoside poisoning: A narrative review

Resuscitation Plus
Introduction: Cardiac glycosides comprise medications such as digoxin and digitoxin, plants, and even certain toad venoms. Intoxication with cardiac glycosides can lead to hemodynamic instability and cardiac arrest.
Jessie Beaulieu, Maude St-Onge
doaj   +1 more source

Hepatoprotective Potential and Histological Studies of Effects of Celosia Argentea L. on Paracetamol-Induced Liver Damage [PDF]

, 2018
Celosia argentea L. is a common vegetable known to possess anti-oxidative and other therapeutic properties. This study evaluates the hepatoprotective activities and histological effects of aqueous extract of Celosia argentea L.
Bello, Oluwakemi A., Dokunmu, Titilope M., Ezekiel, O. M., Ogunlana, Olubanke Olujoke, Oladele, F. W., Oyelade, I. F.   +5 more
core  

Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A

Discover Pharmaceutical Sciences
Several cardiac glycosides, including digoxin, digitoxin, and proscillaridin A, have been originally identified as cardiomyocyte modulators and are currently being investigated for their anticancer properties.
Shreya Somani, Lekhya Menta, Feng Wang-Johanning, Gary Johanning, Seoyeon Hong, Edward Njoo   +5 more
doaj   +1 more source