Results 21 to 30 of about 280,420 (306)

Maslinic acid protects against pressure overload-induced cardiac hypertrophy in mice

Journal of Pharmacological Sciences, 2018
Cardiac hypertrophy is characterized by myocyte hypertrophy, accumulation of cardiac collagen, and reactivation of fetal genes. Maslinic acid (MA) is a pentacyclic triterpene with abundance in olive fruit skin and possesses a number of pharmacological ...
Yan-Ling Liu, Chun-Yan Kong, Peng Song, Heng Zhou, Xing-Sheng Zhao, Qi-Zhu Tang   +5 more
doaj   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source

Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes

Frontiers in Pharmacology, 2022
The bromodomain and extra-terminal domain proteins (BETs) family serve as epigenetic “readers”, which recognize the acetylated histones and recruit transcriptional regulator complexes to chromatin, eventually regulating gene transcription.
Zhirong Lin, Zhenzhen Li, Zhen Guo, Yanjun Cao, Jingyan Li, Peiqing Liu, Zhuoming Li   +6 more
doaj   +1 more source

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy [PDF]

, 2003
It is generally believed that increase in adult contractile cardiac mass can be accomplished only by hypertrophy of existing myocytes. Documentation of myocardial regeneration in acute stress has challenged this dogma and led to the proposition that ...
Anversa P., CASTALDO, CLOTILDE, Kajstura J, Leri A, Nadal Ginard B, Quaini E, Quaini F, Tasca G, Torella D, Urbanek K   +9 more
core   +1 more source

MicroRNAs in Cardiac Hypertrophy [PDF]

International Journal of Molecular Sciences, 2019
Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remodeling, however, is intensified under stress and pathological conditions. Cardiac remodeling could be beneficial for a short period of time, to maintain a normal cardiac output in times of need; however, chronic cardiac hypertrophy may ...
Nadine Wehbe, Suzanne Nasser, Gianfranco Pintus, Adnan Badran, Ali Eid, Elias Baydoun   +5 more
openaire   +3 more sources

Wogonin Inhibits Cardiac Hypertrophy by Activating Nrf-2-Mediated Antioxidant Responses

Cardiovascular Therapeutics, 2021
Background. Cardiac hypertrophy is one of the initial disorders of the cardiovascular system and can induce heart failure. Oxidative stress is an important pathophysiological mechanism of cardiac hypertrophy. Wogonin (Wog), an important flavonoid derived
Xiaowen Shi, Bin Zhang, Zhenliang Chu, Bingjiang Han, Xueping Zhang, Ping Huang, Jibo Han   +6 more
doaj   +1 more source

Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism [PDF]

, 2018
Recent studies suggest that cardiac fibroblast-specific p38α MAPK contributes to the development of cardiac hypertrophy, but the underlying mechanism is unknown.
Ainscough, JFX, Bageghni, SA, Denton, CP, Drinkhill, MJ, Hemmings, KE, Porter, KE, Turner, NA, Zava, N   +7 more
core   +1 more source

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]

, 2017
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco, Bordin, Antonella, Carrizzo, Albino, Chimenti, Isotta, DE FALCO, Elena, Forte, Maurizio, Frati, Giacomo, Nocella, Cristina, Pagano, Francesca, Palmerio, Silvia, Schiavon, Sonia, Schirone, Leonardo, Sciarretta, Sebastiano, Valenti, Valentina, Vecchione, Carmine, Yee, Derek   +15 more
core   +6 more sources

Role of PI3-Kinase in Angiotensin II-Induced Cardiac Hypertrophy: Class I Versus Class III

Frontiers in Pharmacology, 2021
Cardiac hypertrophy is an adaptive response to cardiac overload initially but turns into a decompensated condition chronically, leading to heart failure and sudden cardiac death.
Tiecheng Zhong, Tiecheng Zhong, Zonggui Wang, Sayeman Islam Niloy, Yue Shen, Stephen T. O’Rourke, Chengwen Sun   +6 more
doaj   +1 more source

Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium [PDF]

, 2010
One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training.
Adams, Adams, American College of Sports Medicine Position Stand, American Heart Association, Amundsen, Anderson, Anversa, Beisvag, Belardinelli, Bergmann, Bers, Beyer, Blair, Blair, Boluyt, Bossuyt, Bye, Care, de Waard, Del Monte, Diffee, Diffee, Diffee, Diffee, Eto, Fletcher, Frampton, Gledhill, Gomez, Gulati, Hambrecht, Hambrecht, Haram, Hasenfuss, Helgerud, Hunter, Iemitsu, Jensen, Jolliffe, Kavanagh, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kodoma, Kong, Kuum, Lankford, Laughlin, Lee, Levine, Liang, Liu, Loennechen, McMullen, Moholdt, Mokelke, Mole, Moore, Musch, Myers, Myles, Nakao, Natali, O’Connor, O’Neill, Paffenbarger, Palmer, Pelliccia, Penpargkul, Pluim, Richardson, Richardson, Rognmo, Saltin, Schaible, Schjerve, Shephard, Stolen, Tanasescu, Tate, Tibbits, Tjonna, Venetucci, Wagner, Wilkins, Wisloff, Wisloff, Wisloff, Wisloff, Wisloff, Wisloff, Zhang, Zhang   +98 more
core   +1 more source