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Calcium signaling in cardiac myocytes. [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Calcium (Ca(2+)) is a critical regulator of cardiac myocyte function. Principally, Ca(2+) is the link between the electrical signals that pervade the heart and contraction of the myocytes to propel blood. In addition, Ca(2+) controls numerous other myocyte activities, including gene transcription.
S. Rosenberg, N. Spitzer, T. Heppner, David Hill-Eubanks, H. Roderick, G. Bultynck, J. Parys, Veerle Vanderheyden, Horst A. Henning, L. Combettes, Andrew L. Miller   +10 more
semanticscholar   +3 more sources

Frequency-dependent signaling in cardiac myocytes [PDF]

Frontiers in Physiology, 2022
Background: Recent experimental data support the view that signaling activity at the membrane depends on its geometric parameters such as surface area and curvature.
Payam Haftbaradaran Esfahani, Jan Westergren, Lennart Lindfors, Ralph Knöll, Ralph Knöll   +4 more
doaj   +2 more sources

Redox signaling in cardiac myocytes

Free Radical Biology and Medicine, 2011
The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function in response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload.
Celio X. C. Santos, N. Anilkumar, Min Zhang, A. Brewer, A. Shah   +4 more
semanticscholar   +4 more sources

Heart repair by reprogramming non-myocytes with cardiac transcription factors

Nature, 2012
The adult mammalian heart possesses little regenerative potential following injury. Fibrosis due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contractile function, pathological remodelling and ...
Young-Jae Nam, Guo N Huang, Michelle D Tallquist   +2 more
exaly   +2 more sources

It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3 [PDF]

Communications Biology, 2023
The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac cells revealed NO-induced cGMP signals in cardiac fibroblasts while cardiomyocytes were devoid of these ...
Lukas Menges, Jan Giesen, Kerem Yilmaz, Evanthia Mergia, Annette Füchtbauer, Ernst-Martin Füchtbauer, Doris Koesling, Michael Russwurm   +7 more
doaj   +2 more sources

Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

Molecular and Cellular Biology, 2011
Kyriakos N. Papanicolaou, Ramzi J. Khairallah, Gladys A. Ngoh, Aristide C. Chikando, Ivan Luptak, Karen M. O’Shea, Dushon DeVere Riley, Jesse J. Lugus, Wilson S. Colucci, W. Jonathan Lederer, William C. Stanley, Kenneth Walsh   +11 more
openalex   +3 more sources

Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro. [PDF]

PLoS ONE, 2009
BACKGROUND:Mammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a ...
Carmen H Coxon, Katrina A Bicknell, Fleur L Moseley, Gavin Brooks   +3 more
doaj   +1 more source

Down-regulation of replication factor C-40 (RFC40) causes chromosomal missegregation in neonatal and hypertrophic adult rat cardiac myocytes. [PDF]

PLoS ONE, 2012
BACKGROUND: Adult mammalian cardiac myocytes are generally assumed to be terminally differentiated; nonetheless, a small fraction of cardiac myocytes have been shown to replicate during ventricular remodeling.
Hirotaka Ata, Deepa Shrestha, Masahiko Oka, Rikuo Ochi, Chian Ju Jong, Sarah Gebb, John Benjamin, Stephen Schaffer, Holly H Hobart, James Downey, Ivan McMurtry, Rakhee Gupte   +11 more
doaj   +1 more source

Innate immune signaling in hearts and buccal mucosa cells of patients with arrhythmogenic cardiomyopathy

Heart Rhythm O2, 2023
Background: Nuclear factor κB (NF-κB) signaling in cardiac myocytes causes disease in a mouse model of arrhythmogenic cardiomyopathy (ACM) by mobilizing CCR2-expressing macrophages that promote myocardial injury and arrhythmias.
Carlos Bueno-Beti, PhD, Alessandro Tafuni, MD, Stephen P. Chelko, PhD, FHRS, Mary N. Sheppard, MD, Ella Field, MSc, Jennifer Tollit, MSc, Imogen K. Heenan, BSc, Annabelle Barnes, BSc, Matthew R. Taylor, MD, PhD, Luisa Mestroni, MD, Juan Pablo Kaski, MD, Jeffrey E. Saffitz, MD, PhD, FHRS, Angeliki Asimaki, PhD   +12 more
doaj   +1 more source

PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes. [PDF]

PLoS ONE, 2010
To identify novel transmembrane and secretory molecules expressed in cardiac myocytes, signal sequence trap screening was performed in rat neonatal cardiac myocytes.
Koji Isodono, Tomosaburo Takahashi, Hiroko Imoto, Naohiko Nakanishi, Takehiro Ogata, Satoshi Asada, Atsuo Adachi, Tomomi Ueyama, Hidemasa Oh, Hiroaki Matsubara   +9 more
doaj   +1 more source