Results 101 to 110 of about 19,651 (218)

Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats

Antioxidants
Skeletal muscle changes occur in heart failure (HF). Despite the cardioprotective effects of sodium–glucose co-transporter 2 (SGLT2) inhibitors in HF, their impact on skeletal muscle remains poorly understood.
Lidiane Moreira Souza, Felipe Cesar Damatto, Bruna Brasil Brandão, Eder Anderson Rodrigues, Anna Clara Consorti Santos, Rafael Campos França Silva, Mariana Gatto, Luana Urbano Pagan, Paula Felippe Martinez, Gilson Masahiro Murata, Leonardo Antonio Mamede Zornoff, Paula Schmidt Azevedo Gaiolla, Inês Falcão-Pires, Katashi Okoshi, Marina Politi Okoshi   +14 more
doaj   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

In vitro and in vivo preclinical pharmacokinetic characterisation of ulacamten, a small molecule cardiac myosin inhibitor for the treatment of heart failure with preserved ejection fraction (HFpEF) [PDF]

Mark P. Grillo, Jeanelle Zamora, Ashton N. Easterday, Mina Azimi, Roxanne J. Romond, Bradley P. Morgan, Rajaa Sukhun   +6 more
openalex   +2 more sources

Pharmacokinetics, disposition, and biotransformation of the cardiac myosin inhibitor aficamten in humans [PDF]

Donghong Xu, Punag Divanji, Adrienne Griffith, Rajaa Sukhun, Kathleen Cheplo, Jianlin Li, Polina German   +6 more
openalex   +1 more source

805 Clonal, activated CD8+ T cells recognizing cardiac alpha-myosin drive immune checkpoint inhibitor associated myocarditis in mice [PDF]

, 2021
Margaret L. Axelrod, Wouter C. Meijers, Elie Tannous, Xiaopeng Sun, Juan Qin, Ayaka Sugiura, Elizabeth C. Wescott, Elles M. Screever, Spencer C. Wei, Susan R. Opalenik, Yueli Zhang, Douglas B. Johnson, J. B. Allison, Javid J. Moslehi, Justin M. Balko   +14 more
openalex   +1 more source

Skeletal muscle‐specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice

Experimental Physiology, EarlyView.
Abstract In addition to controlling muscle mass, myostatin may support oxidative metabolism and endurance. Loss of function through gene knockout or post‐natal blockade generally lowers muscle oxidative capacity and increases fatigability. These observations imply that myostatin activation could promote a more oxidative and less fatigable muscle ...
Andy V. Khamoui, Andrea Abraham, Janos Porszasz, Istvan Kovanecz, Silvana Constantinescu, Harry B. Rossiter, Suzanne Reisz‐Porszasz   +6 more
wiley   +1 more source

Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy [PDF]

, 2023
Saswata S. Sarkar, James J. Hartman, Darren T. Hwee, Chih-Yuan Chuang, Peadar Cremin, André deRosier, Samantha Edell, Roshni V. Madhvani, Yangsong Wu, Lisette Yco, Jeanelle Zamora, Anne M. Murphy, B. Paul Morgan, Fady I. Malik   +13 more
openalex   +1 more source

Effects of chemical myosin II cross‐bridge inhibitors on eccentric force production in skinned muscle fibres

Experimental Physiology, EarlyView.
Abstract Eccentric muscle contractions are essential for locomotion and daily activities. Force during these contractions depends on both cross‐bridge (XB) and non‐cross‐bridge (non‐XB) elements, including titin, with contributions varying by fibre type and contraction velocity.
André Tomalka, Sven Weidner, Christian Rode, Tobias Siebert   +3 more
wiley   +1 more source

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source