Results 101 to 110 of about 157,414 (301)

In vitro cultured progenitors and precursors of cardiac cell lineages from human normal and post-ischemic hearts. [PDF]

, 2007
The demonstration of the presence of dividing primitive cells in damaged hearts has sparked increased interest about myocardium regenerative processes.
ARCUCCI, ALESSANDRO, CASTALDO, CLOTILDE, Cotrufo M, de Feo M, De Santo L, DI MEGLIO, FRANCA, Giordano Lanza G., MONTAGNANI, STEFANIA, NURZYNSKA, DARIA ANNA   +8 more
core  

Analysis of pregnancy-associated plasma protein a production in human adult cardiac progenitor cells [PDF]

, 2013
IGF-binding proteins (IGFBPs) and their proteases regulate IGFs bioavailability in multiple tissues. Pregnancy-associated plasma protein A (PAPP-A) is a protease acting by cleaving IGFBP2, 4, and 5, regulating local bioavailability of IGFs.
ANGELINI, FRANCESCO, CHIMENTI, ISOTTA, GIACOMELLO, Alessandro, IONTA, VITTORIA, MESSINA, ELISA, MIRALDI, Fabio, PALA, Alessandro, Piera D'Elia   +7 more
core   +5 more sources

Direct Cardiac Reprogramming: Advances in Cardiac Regeneration

BioMed Research International, 2015
Heart disease is one of the lead causes of death worldwide. Many forms of heart disease, including myocardial infarction and pressure-loading cardiomyopathies, result in irreversible cardiomyocyte death. Activated fibroblasts respond to cardiac injury by forming scar tissue, but ultimately this response fails to restore cardiac function. Unfortunately,
Chen, Olivia, Qian, Li
openaire   +2 more sources

Cardiac Regeneration and Stem Cells [PDF]

Physiological Reviews, 2015
After decades of believing the heart loses the ability to regenerate soon after birth, numerous studies are now reporting that the adult heart may indeed be capable of regeneration, although the magnitude of new cardiac myocyte formation varies greatly.
Yiqiang, Zhang, John, Mignone, W Robb, MacLellan   +2 more
openaire   +2 more sources

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

Sensorized Engineered Tissues with Built‐in Thermoregulation and Nutrient Supply

Advanced Functional Materials, EarlyView.
This work introduces a granular hydrogel‐based tissue engineering platform that includes a closed‐loop temperature control to maintain 37°C and sustainably releases nutrients, thereby enabling cells to retain a high viability even if stored at room temperature for up to 24 h.
Antonia Georgopoulou, Jakob Schreiner, Miriam Filippi, Aiste Balciunaite, Robert K. Katzschmann, Esther Amstad   +5 more
wiley   +1 more source

Targeting Mettl14 Using an RNA‐Targeting Clustered Regularly Interspaced Short Palindromic Repeat‐High‐Fidelity Cas13x System Attenuates Doxorubicin‐Induced Cardiotoxicity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Doxorubicin is an effective chemotherapy drug used to treat various types of cancer. However, doxorubicin treatment is associated with cardiotoxicity, which limits its clinical use.
Wensi Wan, Caiyue Cui, Yi Zhou, Jiaqi Wang, Xuan Zhao, Xinxin Cui, Jiangpeng Sun, Pujiao Yu, Jingyi Feng, Tianhui Wang, Lijun Wang, Jiahong Xu   +11 more
doaj   +1 more source

Gender differences in cardiac left ventricular mass and function: clinical and experimental observations [PDF]

, 2014
Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats.
Aiello, Ernesto Alejandro, Diaz, Alejandro, Ennis, Irene Lucia, Escudero, Eduardo Manuel, Orlowski, Alejandro, Pinilla, Oscar Andres   +5 more
core   +2 more sources

New Developments in Cardiac Regeneration [PDF]

Heart, Lung and Circulation, 2017
Numerous pharmacological and device therapies have improved adverse cardiac remodelling and mortality in heart failure. However, none are able to regenerate damaged cardiac tissue. Stem cell based therapies using multipotent (adult) stem cells and pluripotent stem cells are new approaches that could potentially achieve the elusive goal of true cardiac ...
Thi Yen Loan, Le, Sujitha, Thavapalachandran, Eddy, Kizana, James Jh, Chong   +3 more
openaire   +2 more sources

Multi‐Scale Interface Engineering of MXenes for Multifunctional Sensory Systems

Advanced Functional Materials, EarlyView.
MXenes, as two‐dimensional transition metal carbides and nitrides, demonstrate remarkable capabilities for multifunctional sensing applications. This review systematically examines multi‐scale interface engineering approaches that enhance sensing performance, enable diverse detection functionalities, and improve system‐level compatibility in MXene ...
Jiaying Liao, Sin‐Yi Pang, Jianhua Hao
wiley   +1 more source