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Cardiac tissue engineering [PDF]

Journal of the Serbian Chemical Society, 2005
We hypothesized that clinically sized (1-5 mm thick),compact cardiac constructs containing physiologically high density of viable cells (≈108 cells/cm3) can be engineered in vitro by using biomimetic culture systems capable of providing oxygen transport ...
Radišić Milica, Vunjak-Novaković Gordana   +1 more
doaj   +5 more sources

Ventricular stabilization with a customized decellularized cardiac ECM-based scaffold after myocardial infarction alters gene expression in a rodent LAD-ligation model

Frontiers in Bioengineering and Biotechnology, 2022
Objectives: Decellularized extracellular matrix (dECM) is increasingly used in a wide range of regenerative medicine applications and may also offer the potential to support injured myocardium.
Hug Aubin, Hug Aubin, Lenard Rath, Alexandra Vey, Vera Schmidt, Vera Schmidt, Mareike Barth, Mareike Barth, Elvira Weber, Elvira Weber, Artur Lichtenberg, Artur Lichtenberg, Payam Akhyari, Payam Akhyari   +13 more
doaj   +1 more source

BEaTS-β: an open-source electromechanical bioreactor for simulating human cardiac disease conditions

Frontiers in Bioengineering and Biotechnology, 2023
Heart disease remains the leading cause of worldwide mortality. Although the last decades have broadened our understanding of the biology behind the pathologies of heart disease, ex vivo systems capable of mimicking disease progression and abnormal heart
Hiroki Takaya, Maxime Comtois-Bona, Maxime Comtois-Bona, Ana Spasojevic, David Cortes, David Cortes, Fabio Variola, Wenbin Liang, Wenbin Liang, Marc Ruel, Erik J. Suuronen, Erik J. Suuronen, Emilio I. Alarcon, Emilio I. Alarcon   +13 more
doaj   +1 more source

Diet Rich in Lard Promotes a Metabolic Environment Favorable to Trypanosoma cruzi Growth

Frontiers in Cardiovascular Medicine, 2021
Background:Trypanosoma cruzi is a protozoan parasite that causes Chagas disease and affects 6–7 million people mainly in Latin America and worldwide.
Débora Maria Soares de Souza, Débora Maria Soares de Souza, Débora Maria Soares de Souza, Maria Cláudia Silva, Silvia Elvira Barros Farias, Ana Paula de J. Menezes, Cristiane Maria Milanezi, Karine de P. Lúcio, Nívia Carolina N. Paiva, Paula Melo de Abreu, Daniela Caldeira Costa, Daniela Caldeira Costa, Kelerson Mauro de Castro Pinto, Kelerson Mauro de Castro Pinto, Guilherme de Paula Costa, Guilherme de Paula Costa, João Santana Silva, João Santana Silva, André Talvani, André Talvani, André Talvani   +20 more
doaj   +1 more source

AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration

Cells, 2022
Accumulating evidence indicates that the APOA1 binding protein (AIBP)—a secreted protein—plays a profound role in lipid metabolism. Interestingly, AIBP also functions as an NAD(P)H-hydrate epimerase to catalyze the interconversion of NAD(P)H hydrate [NAD(
Jun-dae Kim, Teng Zhou, Aijun Zhang, Shumin Li, Anisha A. Gupte, Dale J. Hamilton, Longhou Fang   +6 more
doaj   +1 more source

Engineered cardiac tissues [PDF]

Current Opinion in Biotechnology, 2011
Cardiac tissue engineering offers the promise of creating functional tissue replacements for use in the failing heart or for in vitro drug screening. The last decade has seen a great deal of progress in this field with new advances in interdisciplinary areas such as developmental biology, genetic engineering, biomaterials, polymer science, bioreactor ...
Rohin K, Iyer, Loraine L Y, Chiu, Lewis A, Reis, Milica, Radisic   +3 more
openaire   +2 more sources

Cardiac Tissue Engineering [PDF]

Journal of Cardiovascular Nursing, 2009
The first 2 reviews in this series have described the defining properties of stem cells, their possible sources, and some initial attempts at their clinical use for tissue regeneration and repair. This third and final article in the series describes bioengineering methods for building physical structures to contain and organize implanted cells.
Matthew W, Curtis, Brenda, Russell
openaire   +2 more sources

Detection of Abnormal Cardiac Response Patterns in Cardiac Tissue Using Deep Learning

Mathematics, 2022
This study reports a method for the detection of mechanical signaling anomalies in cardiac tissue through the use of deep learning and the design of two anomaly detectors.
Xavier Marimon, Sara Traserra, Marcel Jiménez, Andrés Ospina, Raúl Benítez   +4 more
doaj   +1 more source

The effect of eight weeks high intensity interval training on the expression of cardiac miRNA-21 and miRNA-1 in wistar male rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
Background and Purpose: microRNA (miRNA) are a new class of biomarkers that are involved in many biological processes and gene expression. Also, High-intensity exercise training (HIIT) has long been demonstrated to help improve cardiorespiratory fitness ...
Sohrab Ghalehgir, Javad Vakili, Mostafa Khani, Karim Azali Alamdari   +3 more
doaj   +1 more source

3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography

eLife, 2021
For the first time, we have used phase-contrast X-ray tomography to characterize the three-dimensional (3d) structure of cardiac tissue from patients who succumbed to Covid-19. By extending conventional histopathological examination by a third dimension,
Marius Reichardt, Patrick Moller Jensen, Vedrana Andersen Dahl, Anders Bjorholm Dahl, Maximilian Ackermann, Harshit Shah, Florian Länger, Christopher Werlein, Mark P Kuehnel, Danny Jonigk, Tim Salditt   +10 more
doaj   +1 more source