Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry [PDF]
Frontiers in PhysiologyThe mitochondrial phospholipid cardiolipin (CL) is essential for proper mitochondrial function and energy production. Cardiolipin has four distinct fatty acid tails with varying expression compositions, resulting in a highly variable tissue-specific ...
Katlynn J. Emaus +12 more
doaj +2 more sources
Cardiolipin’s multifaceted role in immune response: a focus on interacting proteins [PDF]
Frontiers in ImmunologyCardiolipin is a unique and essential phospholipid that plays a pivotal role in cellular function. In eukaryotic cells, it is predominantly localized within the mitochondrial membranes, with the highest concentration in the inner mitochondrial membrane ...
Zhuodong Chai +9 more
doaj +2 more sources
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
Nature Communications, 2018 Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.
Rajesh Ambasudhan +2 more
exaly +2 more sources
Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 [PDF]
Nature CommunicationsCardiolipin is a mitochondria-specific phospholipid that forms heterotypic interactions with membrane-shaping proteins and regulates the dynamic remodeling and function of mitochondria. However, the precise mechanisms through which cardiolipin influences
Sirikrishna Thatavarthy +9 more
doaj +2 more sources
Cardiomyopathy in a c.1528G>C Hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species [PDF]
Journal of Lipid ResearchLong-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) is a metabolic disorder caused by the loss of LCHAD enzymatic activity in the α-subunit of the trifunctional protein (TFPα), leading to impaired fatty acid oxidation (FAO).
Chibuike Eke +11 more
doaj +2 more sources
Plaat1 deficiency reduces cardiac cardiolipin content and impairs exercise tolerance [PDF]
Journal of Lipid ResearchPhospholipase A and acyltransferase 1 (PLAAT1) catalyzes O-transacylase, N-transacylase, and phospholipase A1/2 reactions. We have demonstrated that PLAAT1 has O-transacylase activity in vitro using phosphatidylcholine as an acyl donor and ...
Ashkan Hashemi +8 more
doaj +2 more sources
Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry. [PDF]
PLoS ONE, 2013 Cardiolipin, a major component of mitochondria, is critical for mitochondrial functioning including the regulation of cytochrome c release during apoptosis and proper electron transport.
Yuan-Hao Hsu +3 more
doaj +1 more source
Redox Biology, 2023 Cardiolipin is a unique phospholipid of the inner mitochondrial membrane (IMM) as well as in bacteria. It performs several vital functions such as resisting osmotic rupture and stabilizing the supramolecular structure of large membrane proteins, like ATP
Sehwan Jang, Sabzali Javadov
doaj +1 more source
Cell cycle arrest and cell survival induce reverse trends of cardiolipin remodeling. [PDF]
PLoS ONE, 2014 Cell survival from the arrested state can be a cause of the cancer recurrence. Transition from the arrest state to the growth state is highly regulated by mitochondrial activity, which is related to the lipid compositions of the mitochondrial membrane ...
Yu-Jen Chao +4 more
doaj +1 more source
Ischemia In Vivo Induces Cardiolipin Oxidation in Rat Kidney Mitochondria
Biology, 2022 Cardiolipin is a mitochondrial phospholipid that plays a significant role in mitochondrial bioenergetics. Cardiolipin is oxidized under conditions like oxidative stress that occurs during ischemia/reperfusion; however, it is known that even during ...
Arvydas Strazdauskas +5 more
doaj +1 more source