Results 41 to 50 of about 36,754 (231)

Cardiolipin’s Remodeling Rules Revealed: The Role of the Cellular Lipidome

Cell Reports, 2020
In this issue of Cell Reports, Oemer et al. (2020) define the acyl chain composition of cardiolipin and other lipid classes in murine tissues. They then employ artificial neural networks to predict mechanisms that govern cardiolipin tissue specificity ...
Olivia L. Sniezek, Arianna F. Anzmann, Steven M. Claypool, Hilary J. Vernon   +3 more
doaj   +1 more source

Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry

Frontiers in Physiology
The mitochondrial phospholipid cardiolipin (CL) is essential for proper mitochondrial function and energy production. Cardiolipin has four distinct fatty acid tails with varying expression compositions, resulting in a highly variable tissue-specific ...
Katlynn J. Emaus, Katlynn J. Emaus, Carmen A. Dunbar, Carmen A. Dunbar, Joseph Caruso, Brandon T. Ruotolo, Joseph M. Wider, Joseph M. Wider, Joseph M. Wider, Thomas H. Sanderson, Thomas H. Sanderson, Thomas H. Sanderson, Thomas H. Sanderson   +12 more
doaj   +1 more source

Acylation of monolysocardiolipin in rat heart

Journal of Lipid Research, 1999
Cardiolipin is a major mitochondrial membrane glycerophospholipid in the mammalian heart. In this study, the ability of the isolated intact rat heart to remodel cardiolipin and the mitochondrial enzyme activities that reacylate monolysocardiolipin to ...
Brian J. Ma, William A. Taylor, Vernon W. Dolinsky, Grant M. Hatch   +3 more
doaj   +1 more source

Microanalysis of cardiolipin in small biopsies including skeletal muscle from patients with mitochondrial disease

Journal of Lipid Research, 1999
Cardiolipin is a specific mitochondrial phospholipid that is present in mammalian tissues in low concentration. To measure cardiolipin in small biopsies from patients with mitochondrial disease, we developed a new technique that can detect subnanomolar ...
Michael Schlame, Sara Shanske, Steven Doty, Thomas König, Thomas Sculco, Salvatore DiMauro, Thomas J.J. Blanck   +6 more
doaj   +1 more source

Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and function [PDF]

Journal of Bioenergetics and Biomembranes, 2014
Cardiolipin (CL), the signature phospholipid of mitochondria, is involved in a plethora of cellular processes and is crucial for mitochondrial function and architecture. The de novo synthesis of CL in the mitochondria is followed by a unique remodeling process, in which CL undergoes cycles of deacylation and reacylation. Specific fatty acyl composition
Cunqi, Ye, Zheni, Shen, Miriam L, Greenberg   +2 more
openaire   +2 more sources

Patch clamp characterization of the effect of cardiolipin on MscS of E-coli

, 2015
The bacterial mechanosensitive channels MscS and MscL are gated by an increase in membrane tension when the bacterium experiences hypoosmotic shock. It has been well established that membrane lipids modulate the mechanosensitivity and gating behavior of ...
Nakayama, Yoshitaka, Battle, Andrew R., Ridone, Pietro, Battle, Andrew, Martinac, Boris   +4 more
core   +1 more source

Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples

Journal of Lipid Research, 2006
Cardiolipin is a prominent component of the mitochondrial inner membranes contributing to the regulation of multiple discrete mitochondrial functions. Here, we extend shotgun lipidomics to identify and quantitate cardiolipin molecular species directly ...
Xianlin Han, Kui Yang, Jingyue Yang, Hua Cheng, Richard W. Gross   +4 more
doaj   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Cardiolipin and Lyso-cardiolipin Analysis by LC/MS.

, 2013
A. The dominant cardiolipin (18∶1) peak in mass spectrometry was observed as a doubly charged ion in the negative ion mode. B. Cardiolipin was hydrolyzed by iPLA2 in a mixed-micelle assay and the cardiolipin was extracted by the Bligh/Dyer method and ...
Darren S. Dumlao (393530), Edward A. Dennis (66784), Yuan-Hao Hsu (252386), Jian Cao (16485)   +3 more
core   +1 more source