Results 21 to 30 of about 36,754 (231)

Unraveling the mechanisms of cardiolipin function: The role of oxidative polymerization of unsaturated acyl chains

Redox Biology, 2023
Cardiolipin is a unique phospholipid of the inner mitochondrial membrane (IMM) as well as in bacteria. It performs several vital functions such as resisting osmotic rupture and stabilizing the supramolecular structure of large membrane proteins, like ATP
Sehwan Jang, Sabzali Javadov
doaj   +1 more source

Cell cycle arrest and cell survival induce reverse trends of cardiolipin remodeling. [PDF]

PLoS ONE, 2014
Cell survival from the arrested state can be a cause of the cancer recurrence. Transition from the arrest state to the growth state is highly regulated by mitochondrial activity, which is related to the lipid compositions of the mitochondrial membrane ...
Yu-Jen Chao, Wan-Hsin Chang, Hsiu-Chi Ting, Wei-Ting Chao, Yuan-Hao Howard Hsu   +4 more
doaj   +1 more source

Ischemia In Vivo Induces Cardiolipin Oxidation in Rat Kidney Mitochondria

Biology, 2022
Cardiolipin is a mitochondrial phospholipid that plays a significant role in mitochondrial bioenergetics. Cardiolipin is oxidized under conditions like oxidative stress that occurs during ischemia/reperfusion; however, it is known that even during ...
Arvydas Strazdauskas, Sonata Trumbeckaite, Valdas Jakstas, Justina Kamarauskaite, Liudas Ivanauskas, Rasa Baniene   +5 more
doaj   +1 more source

Cardiolipin-Targeted NIR-II Fluorophore Causes “Avalanche Effects” for Re-Engaging Cancer Apoptosis and Inhibiting Metastasis

, 2022
Restoring innate apoptosis and simultaneously inhibiting metastasis by a molecular drug is an effective cancer therapeutic approach. Herein, a large rigid and V-shaped NIR-II dye, DUT850, is rationally designed for potential cardiolipin (CL)-targeted ...
Dandan Ma (561251), Xiaodong Zhang (183379), Xiaojun Peng (721101), Youjun Yang (1409404), Kai Xin (5782271), Fei Pan (255667), Hui Bian (4849063), Xinfu Zhang (1548433), Yi Xiao (135101)   +8 more
core   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Cardiolipin stabilizes respiratory chain supercomplexes

, 2021
Cardiolipin stabilized supercomplexes of Saccharomyces cerevisiae respiratory chain complexes III and IV (ubiquinol:cytochrome c oxidoreductase and cytochrome c oxidase, respectively), but was not essential for their formation in the inner mitochondrial ...
Hunte, Carola, Pfeiffer, Kathy, Gohil, Vishal, Stuart, Rosemary A., Brandt, Ulrich, Greenberg, Miriam L., Schägger, Hermann   +6 more
core   +2 more sources

Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics[S]

Journal of Lipid Research, 2010
Cardiolipin is a class of mitochondrial specific phospholipid, which is intricately involved in mitochondrial functionality. Differences in cardiolipin species exist in a variety of tissues and diseases.
Michael A. Kiebish, Rob Bell, Kui Yang, Toan Phan, Zhongdan Zhao, William Ames, Thomas N. Seyfried, Richard W. Gross, Jeffrey H. Chuang, Xianlin Han   +9 more
doaj   +1 more source

Cardiolipin-Mediated Alleviation of Mitochondrial Dysfunction Is a Neuroprotective Effect of Statin in Animal Model of Ischemic Stroke

, 2023
In clinical settings, the benefit of statin for stroke is debatable as regular statin users may suffer from myalgia, statin-associated myopathy (SAM), and rarely rhabdomyolysis.
Swapnil Raut, Abhishek Sarkar, Bijoyani Ghosh (14516139), Pallab Bhattacharya (453692), Nikita Rana (14516142), Vrushali Thongire, Anupom Borah, Deepaneeta Sarmah (6898931), Swapnil Raut (14516157), Deepaneeta Sarmah, Pallab Bhattacharya, Aishika Datta (11462010), Bijoyani Ghosh, Namrata Vadak, Aishika Datta, Upasna Singh (14516160), Namrata Vadak (14516154), Antra Chaudhary, Shubhrakanta Sahu, Upasna Singh, Vishal Gupta, Shubhrakanta Sahu (14516145), Vishal Gupta (763297), Abhishek Sarkar (2941962), Anupom Borah (3723307), Nikita Rana, Harpreet Kaur, Harpreet Kaur (107427), Vrushali Thongire (14516148), Antra Chaudhary (14516151)   +29 more
core   +1 more source

Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion

Frontiers in Molecular Biosciences, 2021
Cardiolipin is a tetra-acylated di-phosphatidylglycerol lipid enriched in the matrix-facing (inner) leaflet of the mitochondrial inner membrane. Cardiolipin plays an important role in regulating mitochondria function and dynamics.
Yifan Ge, Yifan Ge, Sivakumar Boopathy, Sivakumar Boopathy, Tran H. Nguyen, Tran H. Nguyen, Camila Makhlouta Lugo, Camila Makhlouta Lugo, Luke H. Chao, Luke H. Chao   +9 more
doaj   +1 more source

Thematic Review Series: Glycerolipids. Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes*

Journal of Lipid Research, 2008
In this article, the formation of prokaryotic and eukaryotic cardiolipin is reviewed in light of its biological function. I begin with a detailed account of the structure of cardiolipin, its stereochemistry, and the resulting physical properties, and I ...
Michael Schlame
doaj   +1 more source