Results 21 to 30 of about 33,387 (240)

Structure of Cardiolipin [PDF]

Nature, 1958
PANGBORN1 considered that the glycerylglycero-phosphate skeleton of cardiolipin contained three phosphoric acid and four glycerol residues (I), the six available hydroxyl groups in this structure being esterified with unsaturated fatty acids in the intact phospholipid.
openaire   +2 more sources

Cardiolipin Interactions with Proteins [PDF]

Biophysical Journal, 2015
Cardiolipins (CL) represent unique phospholipids of bacteria and eukaryotic mitochondria with four acyl chains and two phosphate groups that have been implicated in numerous functions from energy metabolism to apoptosis. Many proteins are known to interact with CL, and several cocrystal structures of protein-CL complexes exist.
Planas-Iglesias, Joan, Dwarakanath, Himal, Mohammadyani, Dariush, Yanamala, Naveena, Kagan, Valerian E., Klein-Seetharaman, Judith   +5 more
openaire   +2 more sources

Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry1

Journal of Lipid Research, 2010
An improved high-performance liquid chromatography-mass spectrometry method for the separation and characterization of cardiolipin molecular species is presented.
Paul E. Minkler, Charles L. Hoppel
doaj   +1 more source

Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex

Nature Communications, 2023
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still lacking.
Corey F. Hryc, Venkata K. P. S. Mallampalli, Evgeniy I. Bovshik, Stavros Azinas, Guizhen Fan, Irina I. Serysheva, Genevieve C. Sparagna, Matthew L. Baker, Eugenia Mileykovskaya, William Dowhan   +9 more
doaj   +1 more source

Acylation of monolysocardiolipin in rat heart

Journal of Lipid Research, 1999
Cardiolipin is a major mitochondrial membrane glycerophospholipid in the mammalian heart. In this study, the ability of the isolated intact rat heart to remodel cardiolipin and the mitochondrial enzyme activities that reacylate monolysocardiolipin to ...
Brian J. Ma, William A. Taylor, Vernon W. Dolinsky, Grant M. Hatch   +3 more
doaj   +1 more source

Cardiolipin’s Remodeling Rules Revealed: The Role of the Cellular Lipidome

Cell Reports, 2020
In this issue of Cell Reports, Oemer et al. (2020) define the acyl chain composition of cardiolipin and other lipid classes in murine tissues. They then employ artificial neural networks to predict mechanisms that govern cardiolipin tissue specificity ...
Olivia L. Sniezek, Arianna F. Anzmann, Steven M. Claypool, Hilary J. Vernon   +3 more
doaj   +1 more source

Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence

mBio, 2017
Cardiolipin, an anionic phospholipid that resides at the poles of the inner and outer membranes, is synthesized primarily by the putative cardiolipin synthase ClsA in Shigella flexneri. An S.
Rachael M. Rossi, Lauren Yum, Hervé Agaisse, Shelley M. Payne   +3 more
doaj   +1 more source

Microanalysis of cardiolipin in small biopsies including skeletal muscle from patients with mitochondrial disease

Journal of Lipid Research, 1999
Cardiolipin is a specific mitochondrial phospholipid that is present in mammalian tissues in low concentration. To measure cardiolipin in small biopsies from patients with mitochondrial disease, we developed a new technique that can detect subnanomolar ...
Michael Schlame, Sara Shanske, Steven Doty, Thomas König, Thomas Sculco, Salvatore DiMauro, Thomas J.J. Blanck   +6 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples

Journal of Lipid Research, 2006
Cardiolipin is a prominent component of the mitochondrial inner membranes contributing to the regulation of multiple discrete mitochondrial functions. Here, we extend shotgun lipidomics to identify and quantitate cardiolipin molecular species directly ...
Xianlin Han, Kui Yang, Jingyue Yang, Hua Cheng, Richard W. Gross   +4 more
doaj   +1 more source