Results 101 to 110 of about 180,189 (308)

Ca(2+) signaling in mouse cardiomyocytes with ablated S100A1 protein

, 2009
S100A1 is a Ca(2+)-binding protein expressed at high levels in the myocardium. It is thought to modulate the Ca(2+) sensitivity of the sarcoplasmic reticulum (SR) Ca(2+) release channels (ryanodine receptors or RyRs) and its expression has been shown to ...
Ackermann, G E, Heizmann, C W, Niggli, E, Ackermann, GE, Heizmann, CW, Gusev, K   +5 more
core   +1 more source

Atypically Shaped Cardiomyocytes (ACMs): The Identification, Characterization and New Insights into a Subpopulation of Cardiomyocytes

, 2022
In the adult mammalian heart, no data have yet shown the existence of cardiomyocyte-differentiable stem cells that can be used to practically repair the injured myocardium.
Mi, Xinya, Mariko Omatsu-Kanbe, Omatsu-Kanbe, Mariko, Ryo Fukunaga, Fukunaga, Ryo, Xinya Mi, Matsuura, Hiroshi, Hiroshi Matsuura   +7 more
core   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Divergent Effects of Resveratrol on Rat Cardiac Fibroblasts and Cardiomyocytes

Molecules, 2019
In this study, we tested the potential cardioprotective effects of the phytoalexin resveratrol (Rsv) on primary adult rat cardiac fibroblasts (CF), myofibroblasts (MF) and cardiomyocytes.
Xavier Lieben Louis, Zach Meikle, Laura Chan, Garret DeGagne, Rebecca Cummer, Shannon Meikle, Sampath Krishnan, Liping Yu, Thomas Netticadan, Jeffrey T. Wigle   +9 more
doaj   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Mesenchymal stem cells as the near future of cardiology medicine - truth or wish?

Biomedical Papers, 2019
Cardiac damage is one of major cause of worldwide morbidity and mortality. Despite the development in pharmacotherapy, cardiosurgery and interventional cardiology, many patients remain at increased risk of developing adverse cardiac remodeling.
Michaela Brychtova, Jana-Aletta Thiele, Daniel Lysak, Monika Holubova, Milena Kralickova, Lucie Vistejnova   +5 more
doaj   +1 more source

Phenotyping cultured human cardiomyocytes.

, 2014
Human cardiomyocytes cultured on microscope cover slips where phenotyped using cardiac markers (A) α-MHC (63× magnification) (AF546-labeled secondary antibody [red]) (B) Cx43 (x40) (AF488-labeled primary antibody [green]) and (C) cTnT (40× magnification)
Lynn Morris (7883), Walter R. Lopes de Campos (646288), Lia S. Rotherham (129222), Makobetsa Khati (129233), Grace London (646290), Bongani M. Mayosi (202901), Nthato Chirwa (646289)   +6 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Frontiers in Physiology, 2018
Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction ...
Gabriele G. Schiattarella, Nicola Boccella, Roberta Paolillo, Fabio Cattaneo, Fabio Cattaneo, Valentina Trimarco, Anna Franzone, Anna Franzone, Stefania D’Apice, Giuseppe Giugliano, Laura Rinaldi, Domenica Borzacchiello, Alessandra Gentile, Assunta Lombardi, Antonio Feliciello, Giovanni Esposito, Cinzia Perrino   +16 more
doaj   +1 more source

Origin of cardiomyocytes in the adult heart

, 2015
This review article discusses the mechanisms of cardiomyogenesis in the adult heart. They include the re-entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing cardiomyocytes, which assume an immature replicating cell phenotype ...
Goichberg P., Leri A., Pasqualini F., Anversa P., Rota M.   +4 more
core   +1 more source