Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes [PDF]
Cytotechnology, 2018 Recently, the incidence of myocardial infarction has been increasing annually. Now cell therapy is a major new strategy in the treatment of this public health challenge. Most recently, evidences showed that MSCs can reduce the area of infarction and improve the heart function.
Hui, Jiang +5 more
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New perspectives to repair a broken heart [PDF]
, 2009 The aim of cardiac cell therapy is to restore at least in part the functionality of the diseased or injured myocardium by the use of stem/ progenitor cells.
BARILE, Lucio +9 more
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Frontiers in Cell and Developmental BiologyIntroductionDoxorubicin (DOX) is a highly effective anti-cancer drug, but its clinical applications are limited by its cardiotoxicity. The mechanisms underlying DOX-induced cardiotoxicity (DIC) remain incompletely understood.
Minxia Ke +7 more
doaj +1 more source
A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart. [PDF]
, 2017 Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte, its inhibitory activity to SERCA is regulated by phosphorylation. PLN hypophosphorylation is a common molecular feature in failing heart.
Akaike, Toru +5 more
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Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]
, 2018 Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor +19 more
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The meaning of different forms of structural myocardial injury, immune response and timing of infarct necrosis and cardiac repair [PDF]
, 2015 Although a decline in the all-cause and cardiac mortality rates following myocardial infarction (MI) during the past 3 decades has been reported, MI is a major cause of death and disability worldwide.
Bello, S +5 more
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Cardiomyocytes remuscularize the heart
Nature Biotechnology, 2018 The contractility of the infarcted macaque heart is repaired by cardiomyocytes derived from human embryonic stem cells.
openaire +3 more sources
Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure. [PDF]
, 2018 Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca2+) handling, energy failure and impaired mitophagy resulting in contractile dysfunction and myocyte death.
Bers, Donald M +7 more
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International Journal of Nanomedicine, 2021 Asiri A, Marwani H, Khan SB, Webster T. Int J Nanomedicine. 2015;10(1):89–96. The authors have advised the note section for Figure 1 on page 90 is incorrect. The correct Notes section is as follows: Notes: SEM images showing the distribution
Asiri A, Marwani H, Khan SB, Webster T
doaj
Frontiers in Endocrinology, 2019 This review takes into consideration the main mechanisms involved in cellular remodeling following an ischemic injury, with special focus on the possible role played by non-genomic estrogen effects. Sex differences have also been considered.
Rossella Puglisi +6 more
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