Results 91 to 100 of about 180,189 (308)

S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes [PDF]

, 2011
This study investigated the hypothesis whether S100A1 gene therapy can improve pathological key features in human failing ventricular cardiomyocytes (HFCMs)
Thierry Carrel, Henriette Brinks, Most, Patrick, Eckhart, Andrea D., Walter J. Koch, Sven T. Pleger, Qiu, Gang, Pleger, Sven T, Carrel, Thierry, Koch, Walter J, Mather, Paul J, David Rohde, Katus, Hugo A, Joseph Rabinowitz, Hugo A. Katus, Andrea D. Eckhart, Paul J. Mather, Mirko Voelkers, Arjang Ruhparwar, Rohde, David, Herzog, Nicole, Pleger, Sven T., Brinks, Henriette, Nicole Herzog, Carolin Lerchenmüller, Patrick Most, Rabinowitz, Joseph, Silvestry, Scott, Gang Qiu, Eckhart, Andrea D, Mather, Paul J., Lerchenmüller, Carolin, Katus, Hugo A., Koch, Walter J., Voelkers, Mirko, Ruhparwar, Arjang, Scott Silvestry   +36 more
core   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Compartmentation of cAMP in Cardiomyocytes [PDF]

, 2010
The second messenger cAMP is responsible for β-adrenergic receptor (-AR) stimulation of cardiac function by catecholamines, but is also elevated in response to several other receptors which exert distinct functional effects on the heart. Evidences that spatial segregation of cAMP signalling may explain these observations are reviewed in this chapter ...
Vandecasteele, Grégoire, Fischmeister, Rodolphe   +1 more
openaire   +2 more sources

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Understanding Greater Cardiomyocyte Functions on Aligned Compared to Random Carbon Nanofibers in PLGA [Corrigendum]

International Journal of Nanomedicine, 2021
Asiri A, Marwani H, Khan SB, Webster T. Int J Nanomedicine. 2015;10(1):89–96.   The authors have advised the note section for Figure 1 on page 90 is incorrect. The correct Notes section is as follows: Notes: SEM images showing the distribution
Asiri A, Marwani H, Khan SB, Webster T
doaj  

"Studies on the cardiomyocytic potential of dermal stem cells” [PDF]

, 2008
In Europe, diseases of the heart and circulatory system are the main cause of death; 48% of all deaths are from coronary heart disease, accounting for over 4.30 million deaths each year (European cardiovascular disease statistics 2008). Identifying stem
Cormack, Suzanne Marie
core  

Autocrine effects of PCSK9 on cardiomyocytes

, 2020
Proprotein convertase subtilisin kexin type 9 (PCSK9) is in the focus of cardiovascular research due to its role in hepatic low density lipoprotein (LDL) clearance. However, extrahepatic expression of PCSK9 such as in cardiomyocytes and its regulation by
, Annemarie, Rohrbach, Susanne, Li, Ling, Schlüter, Klaus-Dieter, Kutsche, Hanna Sarah, Schreckenberg, Rolf, Weber, Martin, Schulz, Rainer   +7 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Non-genomic Effects of Estrogen on Cell Homeostasis and Remodeling With Special Focus on Cardiac Ischemia/Reperfusion Injury

Frontiers in Endocrinology, 2019
This review takes into consideration the main mechanisms involved in cellular remodeling following an ischemic injury, with special focus on the possible role played by non-genomic estrogen effects. Sex differences have also been considered.
Rossella Puglisi, Gianfranco Mattia, Alessandra Carè, Giuseppe Marano, Walter Malorni, Walter Malorni, Paola Matarrese   +6 more
doaj   +1 more source

The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection [PDF]

, 2009
The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, Laurice V, Fretwell, LV
core