Results 31 to 40 of about 180,189 (308)

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

eLife
AARS2, an alanyl-tRNA synthase, is essential for protein translation, but its function in mouse hearts is not fully addressed. Here, we found that cardiomyocyte-specific deletion of mouse AARS2 exhibited evident cardiomyopathy with impaired cardiac ...
Zongwang Zhang, Lixia Zheng, Yang Chen, Yuanyuan Chen, Junjie Hou, Chenglu Xiao, Xiaojun Zhu, Shi-Min Zhao, Jing-Wei Xiong   +8 more
doaj   +1 more source

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

Stem Cell Reports, 2017
To predict drug-induced serious adverse events (SAE) in clinical trials, a model using a panel of cells derived from human induced pluripotent stem cells (hiPSCs) of individuals with different susceptibilities could facilitate major advancements in ...
Tadahiro Shinozawa, Koki Nakamura, Masanobu Shoji, Maya Morita, Maya Kimura, Hatsue Furukawa, Hiroki Ueda, Masanari Shiramoto, Kyoko Matsuguma, Yoshikazu Kaji, Ippei Ikushima, Makoto Yono, Shyh-Yuh Liou, Hirofumi Nagai, Atsushi Nakanishi, Keiji Yamamoto, Seigo Izumo   +16 more
doaj   +1 more source

Mechanotransduction regulates inflammation responses of epicardial adipocytes in cardiovascular diseases

Frontiers in Endocrinology, 2022
Adipose tissue is a crucial regulator in maintaining cardiovascular homeostasis by secreting various bioactive products to mediate the physiological function of the cardiovascular system.
Xiaoliang Liu, Lei Liu, Junfei Zhao, Hua Wang, Yifei Li   +4 more
doaj   +1 more source

Transplantation of cryopreserved cardiomyocytes [PDF]

, 2001
Background: The present study examined the survival and rate of contraction of (1) cardiomyocytes cultured from cryopreserved fetal rat myocardium and (2) cryopreserved cultured cardiomyocytes. In addition, the effects of transplantation of cryopreserved
Yokomuro, Hiroki, Li, Ren-Ke, Weisel, Richard D., Yau, Terrence M., Mickle, Donald A.G., Verma, Subodh   +5 more
core   +1 more source

The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts [PDF]

, 2011
The response of transverse (T)-tubules to exercise training in health and disease remains unclear. Therefore, we studied the effect of exercise training on the density and spacing of left ventricle cardiomyocyte T-tubules in normal and remodeled hearts ...
Kemi, Ole J., Wisloff, Ulrik, Koch, Lauren G., Morten A. Hoydal, MacQuaide, Niall, Haram, Per M., Godfrey L. Smith, Steven L. Britton, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Per M. Haram, Lauren G. Koch, Oyvind Ellingsen, Britton, Steven L., Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +17 more
core   +1 more source

No functional TRPA1 in cardiomyocytes

, 2021
Aim There is mounting evidence that TRPA1 has a role in cardiac physiology and pathophysiology. We aim to clarify the site of TRPA1 expression in the heart and in particular whether the channel is expressed in cardiomyocytes.
Bruno K. Podesser, Attila Kiss, Lukas F. Reissig, Fischer, Michael J.M., Ciotu, Cosmin I., Reissig, Lukas F., Rojas-Galvan, Natalia S., Michael J. M. Fischer, Heber, Stefan, Hoebart, Clara, Natalia S. Rojas‐Galvan, Aykac, Ibrahim, Clara Hoebart, Weninger, Wolfgang Johann, Cosmin I. Ciotu, Ibrahim Aykac, Podesser, Bruno Karl, Stefan Heber, Kiss, Attila, Wolfgang J. Weninger   +19 more
core   +1 more source

Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia

Journal of the Formosan Medical Association, 2017
TRB3 (tribbles 3), an apoptosis-regulated gene, increases during endoplasmic reticulum stress. Hypoxia can induce inflammatory mediators and apoptosis in cardiomyocytes.
Wen-Pin Cheng, Huey-Ming Lo, Bao-Wei Wang, Su-Kiat Chua, Ming-Jen Lu, Kou-Gi Shyu   +5 more
doaj   +1 more source

Function of Adenylyl Cyclase in Heart: the AKAP Connection

Journal of Cardiovascular Development and Disease, 2018
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways.
Tanya A. Baldwin, Carmen W. Dessauer
doaj   +1 more source

A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine

Advanced NanoBiomed Research, 2021
Cardiovascular diseases are the leading cause of death worldwide. Discovering new therapies to treat heart disease requires improved understanding of cardiac physiology at a cellular level. Extracellular vesicles (EVs) are plasma membrane‐bound nano‐ and
Karl T. Wagner, Milica Radisic
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source