Results 31 to 40 of about 133,857 (267)

MicroRNAs in cardiomyocyte development [PDF]

WIREs Systems Biology and Medicine, 2010
AbstractMicroRNAs (miRNAs) negatively regulate gene expression at the post‐ transcriptional level, primarily by base‐pairing with the 3′‐untranslated region (3′‐UTR) of their target mRNAs. Many miRNAs are expressed in a tissue/organ‐specific manner and are associated with an increasing number of cell proliferation, differentiation, and tissue ...
Andrea P, Malizia, Da-Zhi, Wang
openaire   +2 more sources

Function of Adenylyl Cyclase in Heart: the AKAP Connection

Journal of Cardiovascular Development and Disease, 2018
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways.
Tanya A. Baldwin, Carmen W. Dessauer
doaj   +1 more source

A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine

Advanced NanoBiomed Research, 2021
Cardiovascular diseases are the leading cause of death worldwide. Discovering new therapies to treat heart disease requires improved understanding of cardiac physiology at a cellular level. Extracellular vesicles (EVs) are plasma membrane‐bound nano‐ and
Karl T. Wagner, Milica Radisic
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Mini Review: the non-neuronal cardiac cholinergic system in type-2 diabetes mellitus

Frontiers in Cardiovascular Medicine
Diabetic heart disease remains the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Both insulin resistance and metabolic derangement, hallmark features of T2DM, develop early and progressively impair cardiovascular function ...
Eng Leng Saw, Martin Fronius, Rajesh Katare, Yoshihiko Kakinuma   +3 more
doaj   +1 more source

Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications

Frontiers in Physiology, 2018
Inflammasomes are high molecular weight protein complexes in the cytosol of immune and other cells that play a critical role in the innate immune system in response to cellular stress.
Gong Chen, Mihail G. Chelu, Mihail G. Chelu, Dobromir Dobrev, Na Li, Na Li, Na Li   +6 more
doaj   +1 more source

The role of amino acid arginine and nitric oxide system in implementing cardioprotective effect of non-opioid analogue of leu-enkephalin in newborn albino rats after intrauterine hypoxia

Russian Open Medical Journal, 2020
Objective ― to evaluate the role of the amino acid arginine in the structure of the non-opioid analogue of leu-enkephalin (NALE) and the involvement of the nitric oxide system in the implementation of its cardioprotective effect in newborn albino rats ...
Elena N. Sazonova, Olga А. Lebed'ko, Natalya A. Tsymbalist, Ilya A. Gusev, Elena Yu. Samarina, Yulia B. Malofey   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Zebrafish as a Model System for Brugada Syndrome

Reviews in Cardiovascular Medicine
Brugada syndrome (BrS) is an inheritable cardiac arrhythmogenic disease, associated with an increased risk of sudden cardiac death. It is most common in males around the age of 40 and the prevalence is higher in Asia than in Europe and the United States.
Leonie Verkerk, Arie O. Verkerk, Ronald Wilders   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source