Results 51 to 60 of about 180,189 (308)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic and pathological conditions, such as myocardial infarction (MI). However, the basic mechanisms driving cardiomyocyte‐derived EV
Margarida Viola, Maarten P. Bebelman, Renee G. C. Maas, Willemijn S. deVoogt, Frederik J. Verweij, Cor S. Seinen, Saskia C. A. deJager, Pieter Vader, Dirk Michiel Pegtel, Joost Petrus Gerardus Sluijter   +9 more
doaj   +1 more source

An immunostaining-based approach for assessing myocardial viability in the infarcted mouse hearts

Frontiers in Cardiovascular Medicine
IntroductionWith the growing need for reliable and precise detection of cell viability in spatial biology, we introduce an antibody-based staining of cardiac troponin I (cTnI) as a simple yet valuable tool for delineating cardiomyocyte viability in the ...
Weili Ouyang, Xueqing Liu, Zheheng Ding, Yanan Ji, Jianfeng Zhao, Hongtao Zhu, Weidong Wu, Zhaoping Ding   +7 more
doaj   +1 more source

Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules

Frontiers in Physiology, 2019
T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and signaling proteins, thereby supporting excitation–contraction coupling. T-tubules are often remodeled in heart failure.
Sarah Helena Vermij, Hugues Abriel, Jan Pavel Kucera   +2 more
doaj   +1 more source

Cre-loxP-mediated genetic lineage tracing: Unraveling cell fate and origin in the developing heart

Frontiers in Cardiovascular Medicine, 2023
The Cre-loxP-mediated genetic lineage tracing system is essential for constructing the fate mapping of single-cell progeny or cell populations. Understanding the structural hierarchy of cardiac progenitor cells facilitates unraveling cell fate and origin
Tao Wang, Xinzhe Chen, Kai Wang, Jie Ju, Xue Yu, Shaocong Wang, Cuiyun Liu, Kun Wang   +7 more
doaj   +1 more source

Myocardial injection of skeletal myoblasts impairs contractility of host cardiomyocytes [PDF]

, 2010
BACKGROUND: Mechanisms underlying improvement of myocardial contractile function after cell therapy as well as arrhythmic side effect remain poorly understood.
Tchantchaleishvili, Vakhtang, Carrel, Thierry P, Siepe, Matthias, Carrel, Thierry P., Giraud, Marie-Noëlle, Tevaearai, Hendrik T., Liechti, Emanuel F., Cook, Stéphane, Tevaearai, Hendrik T   +8 more
core   +1 more source

Decrease in Ca2+ Concentration in Quail Cardiomyocytes Is Faster than That in Rat Cardiomyocytes

, 2022
Mammals and birds have quicker heart rates compared to other species. Mammalian cardiomyocytes have T-tubule membranes that facilitate rapid changes in Ca2+ concentrations.
Hiroaki Ito, Yuhei Ogura, Shukei Sugita, Yoshihiro Ujihara, Masanori Nakamura   +4 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Large extracellular vesicles derived from LPS-preconditioned cardiomyocytes alleviate myocarditis via mediating macrophage polarization and modulating p38 MAPK pathway

Frontiers in Immunology
IntroductionMyocarditis is an inflammatory injury to the myocardium characterized by disrupted intercellular communication, involving macrophages and cardiomyocytes as key players.
Yanjie Jiang, Yanjie Jiang, Yanjie Jiang, Yingnan You, Yaxue Xie, Yaxue Xie, Shan Zhou, Mengjie Ma, Bo Han, Bo Han   +9 more
doaj   +1 more source

Bioengineering Approaches to Mature Human Pluripotent Stem Cell-Derived Cardiomyocytes

Frontiers in Cell and Developmental Biology, 2017
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) represent a potential unlimited cell supply for cardiac tissue engineering and possibly regenerative medicine applications.
Xuetao Sun, Sara S. Nunes, Sara S. Nunes, Sara S. Nunes   +3 more
doaj   +1 more source