Results 51 to 60 of about 234,827 (207)
A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
Advanced NanoBiomed Research, 2021 Cardiovascular diseases are the leading cause of death worldwide. Discovering new therapies to treat heart disease requires improved understanding of cardiac physiology at a cellular level. Extracellular vesicles (EVs) are plasma membrane‐bound nano‐ and
Karl T. Wagner, Milica Radisic
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Mini Review: the non-neuronal cardiac cholinergic system in type-2 diabetes mellitus
Frontiers in Cardiovascular MedicineDiabetic heart disease remains the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Both insulin resistance and metabolic derangement, hallmark features of T2DM, develop early and progressively impair cardiovascular function ...
Eng Leng Saw +3 more
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Frontiers in Physiology, 2018 Inflammasomes are high molecular weight protein complexes in the cytosol of immune and other cells that play a critical role in the innate immune system in response to cellular stress.
Gong Chen +6 more
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Russian Open Medical Journal, 2020 Objective ― to evaluate the role of the amino acid arginine in the structure of the non-opioid analogue of leu-enkephalin (NALE) and the involvement of the nitric oxide system in the implementation of its cardioprotective effect in newborn albino rats ...
Elena N. Sazonova +5 more
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Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. [PDF]
, 2018 FRET-based biosensor experiments in adult cardiomyocytes are a powerful way of dissecting the spatiotemporal dynamics of the complicated signaling networks that regulate cardiac health and disease. However, although much information has been gleaned from
Chen-Izu, Ye +7 more
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Evidence for mechanisms underlying the functional benefits of a myocardial matrix hydrogel for post-MI treatment [PDF]
, 2016 Background There is increasing need for better therapies to prevent the development of heart failure after myocardial infarction (MI). An injectable hydrogel derived from decellularized porcine ventricular myocardium has been shown to halt the post ...
Braden, Rebecca L. +8 more
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Compartmentation of cAMP in Cardiomyocytes [PDF]
, 2010 The second messenger cAMP is responsible for β-adrenergic receptor (-AR) stimulation of cardiac function by catecholamines, but is also elevated in response to several other receptors which exert distinct functional effects on the heart. Evidences that spatial segregation of cAMP signalling may explain these observations are reviewed in this chapter ...
Vandecasteele, Grégoire +1 more
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Zebrafish as a Model System for Brugada Syndrome
Reviews in Cardiovascular MedicineBrugada syndrome (BrS) is an inheritable cardiac arrhythmogenic disease, associated with an increased risk of sudden cardiac death. It is most common in males around the age of 40 and the prevalence is higher in Asia than in Europe and the United States.
Leonie Verkerk +2 more
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Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K [PDF]
, 2018 SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric Gi proteins in many cell types, including cardiomyocytes.
Al-Owais, Moza +6 more
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Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]
, 2016 Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia +17 more
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