Results 61 to 70 of about 133,857 (267)

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies

Frontiers in Bioengineering and Biotechnology, 2020
Cardiovascular diseases represent the major cause of morbidity and mortality worldwide. Multiple studies have been conducted so far in order to develop treatments able to prevent the progression of these pathologies.
Marta Mazzola, Elisa Di Pasquale, Elisa Di Pasquale   +2 more
doaj   +1 more source

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

eLife, 2022
Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that ‘dispersion’ of RyR clusters disrupts Ca2+ homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018).
Xin Shen, Jonas van den Brink, Anna Bergan-Dahl, Terje R Kolstad, Einar S Norden, Yufeng Hou, Martin Laasmaa, Yuriana Aguilar-Sanchez, Ann P Quick, Emil KS Espe, Ivar Sjaastad, Xander HT Wehrens, Andrew G Edwards, Christian Soeller, William E Louch   +14 more
doaj   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

NAD⁺-Dependent Lysine Acetylation Regulates Glucose Uptake and Fatty Acid Oxidation in Cardiomyocytes

Metabolites
Background/Objectives: Stimulation of glucose uptake in response to ischemic stress is important for cardiomyocyte post-ischemic function and survival. In the diabetic myocardium chronically exposed to an excess of circulating lipids, this mechanism is ...
Ettore Vanni, Christophe Montessuit
doaj   +1 more source

Experimental ‏review ‏of ‏cobalt ‏induced cardiomyopathy

Russian Open Medical Journal, 2017
The heart is a target of injury for many chemical compounds, both medically prescribed and not. Pathophysiological mechanisms underlying development of chemical-induced cardiomyopathies vary depending on the inciting agent, and can include: direct toxic ...
Igor ‏V. Zadnipryany, Olga ‏S. Tretiakova, Tatiana P. Sataieva, Walery ‏Zukow   +3 more
doaj   +1 more source

Nanocomposites in 3D Bioprinting for Engineering Conductive and Stimuli‐Responsive Constructs Mimicking Electrically Sensitive Tissue

Advanced NanoBiomed Research, 2022
Rebuilding damaged or diseased tissue by means of biological additive manufacturing has recently gained lot of attention and shown very promising result. Using biofabrication techniques to mimic and replicate natural tissue as well as cell environment is
Fabian Züger, Anna Marsano, Martino Poggio, Maurizio R. Gullo   +3 more
doaj   +1 more source

Mechanobiology of cardiomyocyte development [PDF]

Journal of Biomechanics, 2010
Cardiac cells are under constant, self-generated mechanical stress which can affect the differentiation of stem cells into cardiac myocytes, the development of differentiated cells and the maturation of cells in neonatal mammals. In this article, the effects of direct stretch, electrically induced beating and substrate elasticity on the behavior and ...
Jeffrey G, Jacot, Jody C, Martin, Darlene L, Hunt   +2 more
openaire   +2 more sources

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Cardiac Muscle Cell‐Based Coupled Oscillator Network for Collective Computing

Advanced Intelligent Systems, 2021
Current rate of data generation and the need for real‐time data analytics can benefit from new computational approaches where computation proceeds in a massively parallel way while being scalable and energy efficient.
Xiang Ren, Jorge Gomez, Mohammad Khairul Bashar, Jiaying Ji, Uryan Isik Can, Hsueh-Chia Chang, Nikhil Shukla, Suman Datta, Pinar Zorlutuna   +8 more
doaj   +1 more source