Results 41 to 50 of about 180,189 (308)

Mini Review: the non-neuronal cardiac cholinergic system in type-2 diabetes mellitus

Frontiers in Cardiovascular Medicine
Diabetic heart disease remains the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Both insulin resistance and metabolic derangement, hallmark features of T2DM, develop early and progressively impair cardiovascular function ...
Eng Leng Saw, Martin Fronius, Rajesh Katare, Yoshihiko Kakinuma   +3 more
doaj   +1 more source

Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications

Frontiers in Physiology, 2018
Inflammasomes are high molecular weight protein complexes in the cytosol of immune and other cells that play a critical role in the innate immune system in response to cellular stress.
Gong Chen, Mihail G. Chelu, Mihail G. Chelu, Dobromir Dobrev, Na Li, Na Li, Na Li   +6 more
doaj   +1 more source

The role of amino acid arginine and nitric oxide system in implementing cardioprotective effect of non-opioid analogue of leu-enkephalin in newborn albino rats after intrauterine hypoxia

Russian Open Medical Journal, 2020
Objective ― to evaluate the role of the amino acid arginine in the structure of the non-opioid analogue of leu-enkephalin (NALE) and the involvement of the nitric oxide system in the implementation of its cardioprotective effect in newborn albino rats ...
Elena N. Sazonova, Olga А. Lebed'ko, Natalya A. Tsymbalist, Ilya A. Gusev, Elena Yu. Samarina, Yulia B. Malofey   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Zebrafish as a Model System for Brugada Syndrome

Reviews in Cardiovascular Medicine
Brugada syndrome (BrS) is an inheritable cardiac arrhythmogenic disease, associated with an increased risk of sudden cardiac death. It is most common in males around the age of 40 and the prevalence is higher in Asia than in Europe and the United States.
Leonie Verkerk, Arie O. Verkerk, Ronald Wilders   +2 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function

Advanced Science
Bioelectronic medicine is emerging as a powerful approach for restoring lost endogenous functions and addressing life‐altering maladies such as cardiac disorders.
Olurotimi A. Bolonduro, Zijing Chen, Corey P. Fucetola, Yan‐Ru Lai, Megan Cote, Rofiat O. Kajola, Akshita A. Rao, Haitao Liu, Emmanuel S. Tzanakakis, Brian P. Timko   +9 more
doaj   +1 more source

Mitochondria associated membranes in dilated cardiomyopathy: connecting pathogenesis and cellular dysfunction

Frontiers in Cardiovascular Medicine
Dilated cardiomyopathy (DCM) is a leading cause of heart failure, yet therapeutic options remain limited. While traditional research has focused on mechanisms such as energy deficits and calcium dysregulation, increasing evidence suggests that ...
Pingge He, Hongbo Chang, Yueqing Qiu, Zhentao Wang, Zhentao Wang   +4 more
doaj   +1 more source

Combination of Morroniside and Diosgenin Prevents High Glucose-Induced Cardiomyocytes Apoptosis

Molecules, 2017
Cornus officinalis and Dioscorea opposita are two traditional Chinese medicines widely used in China for treating diabetes mellitus and its complications, such as diabetic cardiomyopathy.
Wen-Xia Pi, Xiao-Peng Feng, Li-Hong Ye, Bao-Chang Cai   +3 more
doaj   +1 more source

Hopx and the Cardiomyocyte Parentage [PDF]

Molecular Therapy, 2015
The dissection of steps that pattern primitive mesoderm toward the cardiovascular lineages is important to our current understanding of cardiovascular development and can instruct regenerative approaches to heart repair.1 Primitive precursors that can adopt a cardiovascular fate, but also a subset of other mesoderm, are marked by the transcription ...
Schneider, MD, Baker, AH, Riley, P
openaire   +3 more sources