Results 41 to 50 of about 234,827 (207)

Reprogramming Fibroblasts into Cardiomyocytes [PDF]

New England Journal of Medicine, 2011
The transdifferentiation of one differentiated cell type into another is the focus of much research activity. A recent study shows that mouse fibroblasts can be transdifferentiated, albeit with low efficiency, into cardiomyocytes.
Charles E, Murry, William T, Pu
openaire   +2 more sources

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

eLife
AARS2, an alanyl-tRNA synthase, is essential for protein translation, but its function in mouse hearts is not fully addressed. Here, we found that cardiomyocyte-specific deletion of mouse AARS2 exhibited evident cardiomyopathy with impaired cardiac ...
Zongwang Zhang, Lixia Zheng, Yang Chen, Yuanyuan Chen, Junjie Hou, Chenglu Xiao, Xiaojun Zhu, Shi-Min Zhao, Jing-Wei Xiong   +8 more
doaj   +1 more source

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

Stem Cell Reports, 2017
To predict drug-induced serious adverse events (SAE) in clinical trials, a model using a panel of cells derived from human induced pluripotent stem cells (hiPSCs) of individuals with different susceptibilities could facilitate major advancements in ...
Tadahiro Shinozawa, Koki Nakamura, Masanobu Shoji, Maya Morita, Maya Kimura, Hatsue Furukawa, Hiroki Ueda, Masanari Shiramoto, Kyoko Matsuguma, Yoshikazu Kaji, Ippei Ikushima, Makoto Yono, Shyh-Yuh Liou, Hirofumi Nagai, Atsushi Nakanishi, Keiji Yamamoto, Seigo Izumo   +16 more
doaj   +1 more source

Mechanotransduction regulates inflammation responses of epicardial adipocytes in cardiovascular diseases

Frontiers in Endocrinology, 2022
Adipose tissue is a crucial regulator in maintaining cardiovascular homeostasis by secreting various bioactive products to mediate the physiological function of the cardiovascular system.
Xiaoliang Liu, Lei Liu, Junfei Zhao, Hua Wang, Yifei Li   +4 more
doaj   +1 more source

Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes [PDF]

, 2003
Background - Further to promoting angiogenesis, cell therapy may be an approach for cardiac regeneration. Recent studies suggest that progenitor cells can transdifferentiate into other lineages. However, the transdifferentiation potential of endothelial
Aicher, A, Badorff, C, Brandes, RP, Busse, R, Dimmeler, S, Fleming, I, Popp, R, Rupp, S, Urbich, C, Zeiher, AM   +9 more
core   +1 more source

Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia

Journal of the Formosan Medical Association, 2017
TRB3 (tribbles 3), an apoptosis-regulated gene, increases during endoplasmic reticulum stress. Hypoxia can induce inflammatory mediators and apoptosis in cardiomyocytes.
Wen-Pin Cheng, Huey-Ming Lo, Bao-Wei Wang, Su-Kiat Chua, Ming-Jen Lu, Kou-Gi Shyu   +5 more
doaj   +1 more source

Identification of murine phosphodiesterase 5A isoforms and their functional characterization in HL-1 cardiac cell line [PDF]

, 2017
Phosphodiesterase 5A (PDE5A) specifically degrades the ubiquitous second messenger cGMP and experimental and clinical data highlight its important role in cardiac diseases.
Barbagallo, Federica, Campolo, Federica, Cardarelli, Silvia, Cornacchione, Marisa, DE ARCANGELIS, Valeria, DI GRAZIA, Antonio, Gianfrilli, Daniele, Giorgi, Mauro, Isidori, Andrea, Lenzi, Andrea, Monaco, Lucia, Naro, Fabio, Pellegrini, Manuela, Zevini, Alessandra   +13 more
core   +1 more source

MicroRNAs in cardiomyocyte development [PDF]

WIREs Systems Biology and Medicine, 2010
AbstractMicroRNAs (miRNAs) negatively regulate gene expression at the post‐ transcriptional level, primarily by base‐pairing with the 3′‐untranslated region (3′‐UTR) of their target mRNAs. Many miRNAs are expressed in a tissue/organ‐specific manner and are associated with an increasing number of cell proliferation, differentiation, and tissue ...
Andrea P, Malizia, Da-Zhi, Wang
openaire   +2 more sources

Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts [PDF]

, 2014
Aims: Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease.
A Beenken, A Kharitonenkov, A Planavila, A Romero-Corral, A Sharma, AD Attie, AK Bose, Bee K. Tan, BK Tan, C Valina, C Yang, D Morabito, DJ Hausenloy, DR Riddell, E Braunwald, Edward W. Hillhouse, Emilio Hirsch, FM Fisher, G Nanayakkara, GC Rodrigo, GD Lopaschuk, H Jiao, H Li, Harpal S. Randeva, J Diaz-Delfin, J Mair, J Yie, J Yie, Jing Chen, JP Bertinchant, L Timmers, LC Clavijo, M Mraz, Manjunath Ramanjaneya, MC Mendoza, Muhammad F. Bari, N Shimizu, PK Shah, R Adya, R Mitra, Raghu Adya, S Doroudgar, S Kenchaiah, S Yusuf, SQ Liu, SQ Liu, Sunil K. Bhudia, T Matsui, T Nishimura, T Thim, T Uebanso, V Lionetti, Vanlata Patel, Y Ogawa, Y Wang   +54 more
core   +7 more sources

Function of Adenylyl Cyclase in Heart: the AKAP Connection

Journal of Cardiovascular Development and Disease, 2018
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways.
Tanya A. Baldwin, Carmen W. Dessauer
doaj   +1 more source