Results 21 to 30 of about 133,857 (267)

Transplantation of cryopreserved cardiomyocytes [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2001
The present study examined the survival and rate of contraction of (1) cardiomyocytes cultured from cryopreserved fetal rat myocardium and (2) cryopreserved cultured cardiomyocytes. In addition, the effects of transplantation of cryopreserved fetal cardiomyocytes were evaluated.Segments of fetal rat myocardial tissue (0.2, 2.0, and 6.0 mm(3) mince size)
Yokomuro, Hiroki, Li, Ren-Ke, Mickle, Donald A.G., Weisel, Richard D., Verma, Subodh, Yau, Terrence M.   +5 more
openaire   +2 more sources

IMMUNOHISTOCHEMICAL EVALUATION OF VASOENDOTHELIAL GROWTH FACTOR RECEPTOR-2 (VEGFR2) EXPRESSION IN RAT CARDIOMYOCYTES UNDER DOXORUBICIN AND BETULONIC ACID AMIDE ADMINISTRATION

Сибирский научный медицинский журнал, 2019
The aim of the study is to perform an immunohistochemical analysis of the expression of the vascular endothelial growth factor receptor 2 (VEGFR2) in the myocardium of Wistar rats in doxorubicin-induced cardiomyopathy and the administration of betulonic ...
L. L. Elena, M. M. Mzhelskaya, E. V. Koldysheva, M. G. Klinnikova   +3 more
doaj   +1 more source

Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination

Frontiers in Pharmacology, 2020
Previous studies have shown an attenuating effect of ginsenoside Re on myocardial injury induced by hypoxia/reoxygenation (H/R). However, the underlying mechanism remains unclear.
Huiyuan Sun, Huiyuan Sun, Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Jianwei Li, Yang Li, Hua Qu, Ruikai Du, Ying Zhang, Feng Xu, Yuheng Li, Caizhi Liu, Guohui Zhong, Shuai Liang, Zizhong Liu, Xingcheng Gao, Xiaoyan Jin, Yingxian Li, Dazhuo Shi   +19 more
doaj   +1 more source

How to alleviate cardiac injury from electric shocks at the cellular level

Frontiers in Cardiovascular Medicine, 2022
Electric shocks, the only effective therapy for ventricular fibrillation, also electroporate cardiac cells and contribute to the high-mortality post-cardiac arrest syndrome.
Pamela W. Sowa, Pamela W. Sowa, Pamela W. Sowa, Aleksander S. Kiełbik, Aleksander S. Kiełbik, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Volker Adams, Olga N. Pakhomova   +9 more
doaj   +1 more source

Reprogramming Fibroblasts into Cardiomyocytes [PDF]

New England Journal of Medicine, 2011
The transdifferentiation of one differentiated cell type into another is the focus of much research activity. A recent study shows that mouse fibroblasts can be transdifferentiated, albeit with low efficiency, into cardiomyocytes.
Charles E, Murry, William T, Pu
openaire   +2 more sources

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

eLife
AARS2, an alanyl-tRNA synthase, is essential for protein translation, but its function in mouse hearts is not fully addressed. Here, we found that cardiomyocyte-specific deletion of mouse AARS2 exhibited evident cardiomyopathy with impaired cardiac ...
Zongwang Zhang, Lixia Zheng, Yang Chen, Yuanyuan Chen, Junjie Hou, Chenglu Xiao, Xiaojun Zhu, Shi-Min Zhao, Jing-Wei Xiong   +8 more
doaj   +1 more source

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

Stem Cell Reports, 2017
To predict drug-induced serious adverse events (SAE) in clinical trials, a model using a panel of cells derived from human induced pluripotent stem cells (hiPSCs) of individuals with different susceptibilities could facilitate major advancements in ...
Tadahiro Shinozawa, Koki Nakamura, Masanobu Shoji, Maya Morita, Maya Kimura, Hatsue Furukawa, Hiroki Ueda, Masanari Shiramoto, Kyoko Matsuguma, Yoshikazu Kaji, Ippei Ikushima, Makoto Yono, Shyh-Yuh Liou, Hirofumi Nagai, Atsushi Nakanishi, Keiji Yamamoto, Seigo Izumo   +16 more
doaj   +1 more source

Mechanotransduction regulates inflammation responses of epicardial adipocytes in cardiovascular diseases

Frontiers in Endocrinology, 2022
Adipose tissue is a crucial regulator in maintaining cardiovascular homeostasis by secreting various bioactive products to mediate the physiological function of the cardiovascular system.
Xiaoliang Liu, Lei Liu, Junfei Zhao, Hua Wang, Yifei Li   +4 more
doaj   +1 more source

Compartmentation of cAMP in Cardiomyocytes [PDF]

, 2010
The second messenger cAMP is responsible for β-adrenergic receptor (-AR) stimulation of cardiac function by catecholamines, but is also elevated in response to several other receptors which exert distinct functional effects on the heart. Evidences that spatial segregation of cAMP signalling may explain these observations are reviewed in this chapter ...
Vandecasteele, Grégoire, Fischmeister, Rodolphe   +1 more
openaire   +2 more sources

Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia

Journal of the Formosan Medical Association, 2017
TRB3 (tribbles 3), an apoptosis-regulated gene, increases during endoplasmic reticulum stress. Hypoxia can induce inflammatory mediators and apoptosis in cardiomyocytes.
Wen-Pin Cheng, Huey-Ming Lo, Bao-Wei Wang, Su-Kiat Chua, Ming-Jen Lu, Kou-Gi Shyu   +5 more
doaj   +1 more source