Results 31 to 40 of about 20,955 (188)

Doxorubicin-induced cardiotoxicity and risk factors

International Journal of Cardiology: Heart & Vasculature
Doxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent to treat solid tumours and hematologic malignancies. Although useful in the treatment of cancers, the benefit of DOX is limited due to its cardiotoxic effect that is
Carl Belger, Carmelita Abrahams, Aqeela Imamdin, Sandrine Lecour   +3 more
doaj   +1 more source

Expression and Activation of BKCa Channels in Mice Protects Against Ischemia-Reperfusion Injury of Isolated Hearts by Modulating Mitochondrial Function

Frontiers in Cardiovascular Medicine, 2019
Aims: Activation and expression of large conductance calcium and voltage-activated potassium channel (BKCa) by pharmacological agents have been implicated in cardioprotection from ischemia-reperfusion (IR) injury possibly by regulating mitochondrial ...
Sumanta Kumar Goswami, Sumanta Kumar Goswami, Devasena Ponnalagu, Devasena Ponnalagu, Ahmed T. Hussain, Kajol Shah, Priyanka Karekar, Priyanka Karekar, Shubha Gururaja Rao, Shubha Gururaja Rao, Andrea L. Meredith, Mahmood Khan, Mahmood Khan, Harpreet Singh, Harpreet Singh   +14 more
doaj   +1 more source

TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury. [PDF]

PLoS ONE, 2014
Recent work shows that cooling protection after mouse cardiac arrest and cardiomyocyte ischemia is mediated by Akt activation. The PI3K p85 subunit can either augment or inhibit Akt activation depending on its binding to p110 or PTEN respectively.
Xiangdong Zhu, Zuo-Hui Shao, Changqing Li, Jing Li, Qiang Zhong, Jonathan Learoyd, Angelo Meliton, Lucille Meliton, Alan R Leff, Terry L Vanden Hoek   +9 more
doaj   +1 more source

Remote Conditioning by Rhythmic Compression of Limbs Ameliorated Myocardial Infarction by Downregulation of Inflammation via A2 Adenosine Receptors

Frontiers in Cardiovascular Medicine, 2022
BackgroundRemote ischemic conditioning (RIC) is a cardioprotective phenomenon, yet transient ischemia is not a requisite trigger for remote cardioprotection.
Senlei Xu, Senlei Xu, Renjun Gu, Xiangyu Bian, Xin Xu, Xuefeng Xia, Yuchen Liu, Chengjie Jia, Yihuang Gu, Hongru Zhang, Hongru Zhang   +10 more
doaj   +1 more source

Impact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats.

PLoS ONE, 2015
BackgroundMitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels are involved in myocardial ischemic preconditioning. Their role in sildenafil-induced cardioprotection is unknown.
Friederike Behmenburg, Marianne Dorsch, Ragnar Huhn, David Mally, André Heinen, Markus W Hollmann, Marc M Berger   +6 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles: Mitochondrial Ion Channels and Cardioprotection

Journal of Pharmacological Sciences, 2009
Mitochondrial ATP-sensitive K+ (mitoKATP) and Ca2+-activated K+ (mitoKCa) channels exist in cardiac myocytes, and they play key roles in cardioprotection.
Hirofumi Nishida, Toshiaki Sato, Takehiko Ogura, Haruaki Nakaya   +3 more
doaj   +1 more source

Cardioprotection and its Translation: A Need for New Paradigms? Or for New Pragmatism? An Opinionated Retro- and Perspective

Journal of Cardiovascular Pharmacology and Therapeutics, 2023
The dawn of cardioprotection by infarct size reduction originated from the idea to favourably alter the oxygen demand–supply balance of the ischaemic/infarcting myocardium by reducing the contractile determinants of its oxygen consumption.
Gerd Heusch MD, FACC, FESC, FRCP
doaj   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source