Evaluating the cancer therapeutic potential of cardiac glycosides [PDF]
, 2014 Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na(+)/K(+)
Burgos Morón, Estefanía +5 more
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Cardiorenal Syndrome Type 4—Cardiovascular Disease in Patients with Chronic Kidney Disease: Epidemiology, Pathogenesis, and Management [PDF]
, 2011 The term cardiorenal syndrome refers to the interaction between the heart and the kidney in disease and encompasses five distinct types according to the initial site affected and the acute or chronic nature of the injury.
Panagiotis Pateinakis +1 more
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Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials. [PDF]
, 2019 Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion.
Ahmad, T +10 more
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Ion pumps as biological targets for decavanadate [PDF]
, 2013 The putative applications of poly-, oligo- and mono-oxometalates in biochemistry, biology, pharmacology and medicine are rapidly attracting interest. In particular, these compounds may act as potent ion pump inhibitors and have the potential to play a ...
Aureliano, M.
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Correlation between endogenous polyamines in human cardiac tissues and clinical parameters in patients with heart failure [PDF]
, 2016 This work was supported by a grant from the Instituto de Salud Carlos III(FISS03-1497), from which Clara Meana was recipient of a fellowships. CM, CB and LS designed and performed the biochemical experiments, JB designed and performed the experiments of ...
Bordallo Landa, Javier +5 more
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Hemodynamic Profile of the Cardiotonic Agent Pimobendan
Journal of Cardiovascular Pharmacology, 1989 Pimobendan (UD-CG 115 BS) is a potent positive inotropic agent with vasodilatory properties. This hemodynamic profile was demonstrated in conscious rabbits chronically instrumented with Doppler flow probes. Pimobendan (10, 30, 100, and 300 micrograms/kg i.v.) increased cardiac output, stroke volume, heart rate, and mesenteric, renal, and hindquarter ...
J C, van Meel, W, Diederen
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Resuscitation after experimental cardiac arrest. [PDF]
, 1953 Thesis (M.A.)--Boston ...
Salvador, Richard Anthony
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Chemical and Pharmaceutical Bulletin, 1991 A series of novel 4,5-dihydro-5-methyl-6-(2 or 4-substituted 7-quinazolinyl)-3(2H)-pyridazinones was synthesized and examined for cardiotonic activity in anesthetized dogs. The 4-substituted aminoquinazolines generally showed potent and long-lasting inotropic activity.
Y, Nomoto, H, Takai, T, Ohno, K, Kubo
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Origins of Plant Derived Medicines [PDF]
, 2008 This review article describes the origins of plant derived medicines that have been developed as a result of traditional knowledge being handed down from one generation to the next.
De Britto, A. John, Maridass, Muthia
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Prospecting endophytic fungal assemblage of Digitalis lanata Ehrh. (foxglove) as a novel source of digoxin: a cardiac glycoside [PDF]
, 2012 Endophytes, the chemical synthesizers inside plants, are the microorganisms having mutualistic relationship with the host plant. They can be used by plants for defense in addition to the production of a wide variety of beneficial bioactive secondary ...
Khalid Zargar +4 more
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