Results 1 to 10 of about 3,273,209 (295)
Cardiotonic Steroids as a Potential Novel Approach for Immunomodulation in Inflammatory Bowel Disease. [PDF]
J Clin MedInflammatory bowel disease (IBD) is a chronic condition that significantly impairs the quality of life of millions of individuals. The pathogenesis of IBD is closely linked to dysbiosis of microbiota and the activation of various inflammatory pathways ...
Cavalcante-Silva LHA +5 more
europepmc +2 more sources
Procedural Characteristics and Safety of Slender Percutaneous Coronary Intervention: Slender Is Better. [PDF]
Catheter Cardiovasc IntervABSTRACT Objectives We aimed to examine the procedural characteristics and safety profile of slender percutaneous coronary interventions (PCI) using a 5 Fr or smaller sheath. Background Smaller catheter size has been associated with fewer complications in PCI.
Yoshimachi F +11 more
europepmc +2 more sources
Mechanisms of Action of Novel Cardiotonic Agents
Journal of Cardiovascular Pharmacology, 2002 Regulation of myocardial contractility by cardiotonic agents is achieved by an increase in intracellular Ca2+ mobilization (upstream mechanism), an increase in Ca2+ binding affinity to troponin C (central mechanism), or facilitation of the process subsequent to Ca2+ binding to troponin C (downstream mechanism).
M. Endoh
openaire +3 more sources
Effects of statins on serum sCD40, sCD146 and PAPP-An in patients with coronary heart disease [PDF]
Journal of Medical BiochemistryBackground: To analyse the effects of statins on the levels of sCD40, sCD146 and PAPP-An in patients with coronary heart disease (CHD). Methods: 126 patients with CHD treated from September 2022 to September 2024 were divided into a study group (n = 84 ...
Li Huawen +3 more
doaj +2 more sources
Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]
ChemistryWe describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N +3 more
europepmc +2 more sources
Synthesis of Milrinone, a Cardiotonic Agent
HETEROCYCLES, 1990 A new synthesis of milrinone from 6-methyl-5-(4-pyridinyl)-2(1H)-pyridone is reported. A convenient synthesis of 3,4'-bipyridines is achieved. They can be converted into pyridone by hydrogenolysis and hydrolysis, respectively.
Min-Jen Shiao +2 more
openaire +2 more sources
Journal of Medicinal Chemistry, 1987 A series of 4-alkyl-1,3-dihydro-5-[(1H-imidazolyl)benzoyl]-2H-imidazol-2-ones 9 was synthesized and evaluated in vitro for positive inotropic and cyclic AMP phosphodiesterase inhibitory activity. A wide range of inotropic and enzyme-inhibitory potencies was observed, substitution on the imidazolyl moiety being the major determinant of activity.
A A, Hagedorn +9 more
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Acute poisoning by cardiovascular agents [PDF]
Vojnosanitetski Pregled, 2003 In order to determine the frequency, severity of poisoning, and the efficacy of the applied therapeutic measures, retrospective study of 391 patients treated for acute drug poisoning was performed during one-year period at the Clinic for Emergency and ...
Vučinić Slavica +5 more
doaj +1 more source