Frontiers in Pharmacology, 2023 Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered.
Ji-Chao Zhou +20 more
doaj +1 more source
Lipid Emulsion to Treat Acute Poisonings: Mechanisms of Action, Indications, and Controversies
Pharmaceutics, 2023 Biodetoxification using intravenous lipid emulsion (ILE) in acute poisoning is of growing interest. As well as for local anesthetics, ILE is currently used to reverse toxicity caused by a broad-spectrum of lipophilic drugs.
Karim Jaffal +2 more
doaj +1 more source
The hypotensive effect of salt substitutes in stage 2 hypertension:a systematic review and meta-analysis [PDF]
, 2020 Background: Hypertension (HTN) is a ubiquitous risk factor for numerous non-communicable diseases, including cardiovascular disease and stroke. There are currently no wholly effective pharmacological therapies for subjects with HTN.
Clark, Cain C T +4 more
core +2 more sources
Specific Clinical Features of Acute Coronary Syndrome after Surgical Treatment [PDF]
, 2023 Acute coronary syndrome is a serious life-threatening condition that often serves as the clinical debut of ischemic heart disease. In 20-25% of cases, angina pectoris begins with acute myocardial infarction and painful angina after acute myocardial ...
Yarashovich, Hojiyev Avazbek
core +2 more sources
Therapeutic Effect of Echium amoenum on Isoproterenol-Induced Heart Failure in Male Rat [PDF]
Research Journal of PharmacognosyBackground and objectives: Echium amoenum has shown anti-inflammatory and antioxidants properties and is suggested for heart disease in Persian medicine. Methods: To evaluate its cardioprotective effects, 50 male Wistar rats were divided into five groups:
Hossein Jafari +6 more
doaj +1 more source
Seminars in Anesthesia, Perioperative Medicine and Pain, 1996 D RUGS THAT INCREASE the positive inotropic (ie, cardiotonic) potential of the myocardium are used in a variety of clinical settings. All catecholamines exert their inotropic effects by stimulating adrenergic mediated receptors in the sympathetic nervous system.
Stephen N. Harris, Roberta Hines
openaire +2 more sources
Precision medicine considerations for the management of heart disease and stroke in East Asians
Cardiology Plus, 2020 Heart disease is the leading cause of death in Asian Americans. Importantly, people of East Asian descent are more likely to carry a loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2, which reduces ALDH2 enzymatic activity by ...
Candida L Goodnough, Eric R Gross
doaj +1 more source
Micropropagation for the production of high quality phytochemicals [PDF]
, 2013 Plants area source of many valuable secondary metabolites that find a broad field of applications, ranging from the agrochemical to the pharmaceutical industries.
Grevenstuk, Tomás, Romano, Anabela
core +1 more source
Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect
Azar Hosseini +3 more
doaj +1 more source
Target Identification of Marine Natural Product Odoamide:Odoamide Induces Apoptotic Cell Death by Targeting ATPase Na<sup>+</sup>/K<sup>+</sup> Transporting Subunit Alpha 1 (ATP1A1). [PDF]
ChembiochemOdoamide, a member of the aurilide‐family, exhibits highly potent cytotoxicity against various cancer cell lines. This study clarifies the target protein and MOA of odoamide by an affinity‐based methodology, followed by analyses of the binding protein and odoamide‐resistant cells.
Katsumata R +11 more
europepmc +2 more sources