Results 31 to 40 of about 3,273,209 (295)

Ethnomedicine of the Kagera Region, north western Tanzania. Part 3: plants used in traditional medicine in Kikuku village, Muleba District. [PDF]

, 2012
BACKGROUND\ud \ud The Kagera region of north western Tanzania has a rich culture of traditional medicine use and practice. Traditional medicines are the mainstay of healthcare in this region and are known to support the management of many illnesses such ...
Moshi, Mainen J, Otieno, Donald F, Weisheit, Anke   +2 more
core   +2 more sources

Propyl Gallate, a Strong Antioxidant, Increases the Ca2+ Sensitivity of Cardiac Myofilament

Journal of Pharmacological Sciences, 2009
Ca2+ sensitizers are cardiotonic agents that directly increase the Ca2+ sensitivity of cardiac myofilament. To find a novel Ca2+ sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca2+-dependent force generation ...
Naoto Tadano, Sachio Morimoto, Fumi Takahashi-Yanaga, Yoshikazu Miwa, Iwao Ohtsuki, Toshiyuki Sasaguri   +5 more
doaj   +1 more source

Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [Na+]i/[K+]i-Dependent Gene Expression

Frontiers in Physiology, 2020
Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na+ and K+ across plasma membrane of ...
Olga Dmitrievna Lopina, Artem Mikhaylovich Tverskoi, Artem Mikhaylovich Tverskoi, Elizaveta Andreevna Klimanova, Svetlana Vadimovna Sidorenko, Sergei Nikolaevich Orlov   +5 more
doaj   +1 more source

Micropropagation for the production of high quality phytochemicals [PDF]

, 2013
Plants area source of many valuable secondary metabolites that find a broad field of applications, ranging from the agrochemical to the pharmaceutical industries.
Grevenstuk, Tomás, Romano, Anabela
core   +1 more source

Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels

ESC Heart Failure, 2023
Aims Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers ...
Arnold Péter Ráduly, Attila Tóth, Fruzsina Sárkány, Balázs Horváth, Norbert Szentandrássy, Péter P. Nánási, Zoltán Csanádi, István Édes, Zoltán Papp, Attila Borbély   +9 more
doaj   +1 more source

Studies on cardiotonic agents. III. Synthesis of 1-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-3-substituted 2-imidazolidinone and 2-imidazolidinethione derivatives.

Chemical and pharmaceutical bulletin, 1990
Y. Nomoto, H. Obase, H. Takai, T. Hirata, M. Teranishi, J. Nakamura, T. Ohno, K. Kubo   +7 more
semanticscholar   +3 more sources

Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study [PDF]

, 2013
ObjectiveAcidosis produces a negative inotropic effect on cardiac muscle against which catecholamines and phosphodiesterase III inhibitors have limited therapeutic effects. This study evaluated the effects of colforsin, which directly activates adenylate
Hagiya Keiichi, Inomata Shinichi, Isaka Yumi, Takahashi Hiroshi, Tanaka Makoto, 猪股 伸一, 田中 誠, 高橋 宏   +7 more
core   +1 more source

Bioinspired Synthesis of Twin abeo‐Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Twin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Zoey J. Surma, Volodymyr Hiiuk, Eugene Zviagin, Yaxin Ouyang, Alex Chacko, Fengrui Qu, Paul M. Zimmerman, Pavel Nagorny   +7 more
wiley   +2 more sources

A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells [PDF]

, 2013
Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium oleander has been used in traditional medicine for treating several disorders including cancer, and extracts from the leaves of this ...
Burgos Morón, Estefanía, Calderón Montaño, José Manuel, López Lázaro, Miguel, Mateos Cordero, Santiago, Orta Vázquez, Manuel Luis   +4 more
core   +2 more sources

Heart Transplantation as a Treatment Method for Refractory Heart Failure due to Post-myocarditis Dilated Cardiomyopathy: a Clinical Case

Вопросы современной педиатрии, 2019
Background. Implementation of mechanical circulatory support and heart transplantation technologies in paediatric clinical practice is changing approaches of diagnostics and treatment of heart failure (HF) in children. The experience of carrying out such
Larisa A. Balykova, Elena I. Naumenko, Nataljya V. Ivyanskaya, Yulia A. Petrushkina, Ekaterina A. Vlasova, Nadezhda N. Urzjaeva, Irina V. Leontieva, Anna N. Urzjaeva   +7 more
doaj   +1 more source