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Cardiotoxicity of Anthracyclines [PDF]

Frontiers in Cardiovascular Medicine, 2020
Cardiotoxicity is a feared side effect that may limit the clinical use of anthracyclines. It may indeed affect the quality of life and survival of patients with cancer, regardless of oncological prognosis. This paper provides an overview of anthracycline-
Daniela Cardinale, Fabiani Iacopo, Carlo Maria Cipolla   +2 more
doaj   +3 more sources

Immune Checkpoint Inhibitor-Associated Cardiotoxicity in Solid Tumors: Real-World Incidence, Risk Factors, and Prognostic Analysis

Frontiers in Cardiovascular Medicine, 2022
BackgroundImmune checkpoint inhibitors (ICIs) have achieved acknowledged progress in cancer therapy. However, ICI-associated cardiotoxicity as one of the most severe adverse events is potentially life-threatening, with limited real-world studies ...
Xue Chen, Aimin Jiang, Rui Zhang, Xiao Fu, Na Liu, Chuchu Shi, Jingjing Wang, Xiaoqiang Zheng, Tao Tian, Xuan Liang, Zhiping Ruan, Yu Yao   +11 more
doaj   +1 more source

Toll-like Receptor 4 Inflammatory Perspective on Doxorubicin-Induced Cardiotoxicity

Molecules, 2023
Doxorubicin (Dox) is one of the most frequently used chemotherapeutic drugs in a variety of cancers, but Dox-induced cardiotoxicity diminishes its therapeutic efficacy.
Natticha Sumneang, Pongpan Tanajak, Thura Tun Oo   +2 more
doaj   +1 more source

Paracetamol cardiotoxicity [PDF]

Postgraduate Medical Journal, 1993
Summary A 29 year old man with a significant paracetamol overdose was found to have an abnormal electrocardiograph which, in the absence of hepatic encephalopathy, was considered due to a direct cardiotoxic effect of the drug. A functional coronary insufficiency resulting from inhibition of endothelium-derived relaxing factor secondary ...
A, Armour, S D, Slater
openaire   +2 more sources

Cardiovascular complications in patients with cancer: focus on anthracycline-induced cardiotoxicity

Кардиоваскулярная терапия и профилактика, 2021
The article describes prevalence and risk factors of cardiovascular in patients with cancer. The problems of anthracycline-induced cardiotoxicity, the deleterious effects of doxorubicin on the heart, as well as the cardioprotective effects of beta ...
I. T. Murkamilov, K. A. Aitbaev, V. V. Fomin, I. O. Kudaibergenova, F. A. Yusupov, Zh. A. Murkamilova   +5 more
doaj   +1 more source

Clinical features of anthracycline‐induced cardiotoxicity in patients with malignant lymphoma who received a CHOP regimen with or without rituximab: A single‐center, retrospective observational study

eJHaem, 2020
We investigated the incidence of cardiotoxicity, its risk factors, and the clinical course of cardiac function in patients with malignant lymphoma (ML) who received a cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) regimen.
Takafumi Nakayama, Yoshiko Oshima, Shigeru Kusumoto, Junki Yamamoto, Satoshi Osaga, Haruna Fujinami, Takaki Kikuchi, Tomotaka Suzuki, Haruhito Totani, Shiori Kinoshita, Tomoko Narita, Asahi Ito, Masaki Ri, Hirokazu Komatsu, Kazuaki Wakami, Toshihiko Goto, Tomonori Sugiura, Yoshihiro Seo, Nobuyuki Ohte, Shinsuke Iida   +19 more
doaj   +1 more source

Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α

Cell Death and Disease, 2022
Doxorubicin (DOX)-based chemotherapy is widely used to treat malignant tumors; however, the cardiotoxicity induced by DOX restricts its clinical usage. A therapeutic dose of DOX can activate ubiquitin-proteasome system. However, whether and how ubiquitin-
Yihui Shen, Hui Zhang, Yangyue Ni, Xuejun Wang, Yifan Chen, Jiahui Chen, Yan Wang, Jinyi Lin, Yuchen Xu, Jian-Yuan Zhao, Leilei Cheng   +10 more
doaj   +1 more source

Tight Regulation of Erk Activity Protects From Anthracycline-Induced Cardiotoxicity. [PDF]

JACC CardioOncol
Coppe B, Mercader N.
europepmc   +2 more sources

Patterns of CMR measured longitudinal strain and its association with late gadolinium enhancement in patients with cardiac amyloidosis and its mimics

Journal of Cardiovascular Magnetic Resonance, 2017
Background Regional variability of longitudinal strain (LS) has been previously described with echocardiography in patients with cardiac amyloidosis (CA), however, the reason for this variability is not completely evident.
Lynne K. Williams, Julian F. Forero, Zoran B. Popovic, Dermot Phelan, Diego Delgado, Harry Rakowski, Bernd J. Wintersperger, Paaladinesh Thavendiranathan   +7 more
doaj   +1 more source

57884 Fast strain-encoded cardiac magnetic resonance detects immune checkpoint inhibitor associated cardiotoxicity

Journal of Clinical and Translational Science, 2021
IMPACT: Advanced cardiac magnetic resonance imaging techniques can help to protect cancer patients from cardiotoxicity from immunotherapy with a more sensitive assessment of cardiac function with strain imaging for detection of abnormal cardiac function ...
Jason Cuomo, Elio Ragheb, Attila Feher, Jennifer M. Kwan, Steffen Huber, Hamid Mojibian, Dana C. Peters, Albert Sinusas, Lauren A. Baldassarre   +8 more
doaj   +1 more source