Results 41 to 50 of about 97,116 (340)
Journal of the American College of Cardiology, 1985 Clinical manifestations of digitalis toxicity were clearly described by Withering in 1785. One hundred years later, certain digitalis-induced arrhythmias were inscribed on the smoked drum, and shortly thereafter with the introduction of the electrocardiograph, manifestations of digitalis toxicity as recognized today were recorded in animals and human ...
Fisch, Charles, Knoebel, Suzanne B.
openaire +2 more sources
Cardiotoxicity with Itraconazole [PDF]
BMJ Case Reports, 2017 Itraconazole is a commonly used antifungal drug. In addition to commonly described adverse effects, there have been few reports of heart failure with its use. We present two cases that developed acute systolic heart failure with Itraconazole use. A man in his early 30s was admitted with worsening leg swelling and dyspnoea on exertion.
Vishesh, Paul, Harsh, Rawal
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Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab [PDF]
, 2012 Trastuzumab (TZM), a monoclonal antibody against the ERBB2 protein, increases survival in ERBB2-positive breast cancer patients. Its clinical use, however, is limited by cardiotoxicity. We sought to evaluate whether TZM cardiotoxicity involves inhibition
A. c. Wolff +12 more
core +1 more source
Environment InternationalThe usage of pesticides in agriculture is substantial, but their application may pose potential risks of physical harm. Existing network toxicology methods for analysis and prediction lack the capability for structural early-warning of toxicity and are ...
Qi Yang +8 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura +5 more
wiley +1 more source
Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress [PDF]
, 2015 Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with ...
Antonilli, Letizia +5 more
core +4 more sources
Frontiers in OncologyBreast cancer is a major health challenge for women worldwide, and human epidermal growth factor receptor 2 (HER-2)-positive breast cancers have a relatively high incidence and are highly aggressive.
Xiang Zhang +4 more
doaj +1 more source
Utility of myocardial work by echocardiography in the early diagnosis of cardiotoxicity [PDF]
Exploration of CardiologyAim: Evaluate the role of myocardial work by echocardiography and determine its utility as an early diagnosis of cardiotoxicity. Methods: Single-center included 180 patients over 18 years old undergoing chemotherapy, the definition of cardiotoxicity for ...
Denise Cortes-Pérez +4 more
doaj +1 more source
The puzzling clinical presentation of fluoropyrimidines cardiotoxicity
Frontiers in Cardiovascular Medicine, 2022 The cardiotoxicity of fluoropyrimidines (FP) [5-Fluorouracil and Capecitabine] is often reported as acute cardiac ischemia with rest typical angina, signs of ischemia at electrocardiogram (ECG), and ventricular kinetics abnormalities.
Linda Cucciniello +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker +7 more
wiley +1 more source